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TERB2 telomere repeat binding bouquet formation protein 2 [ Homo sapiens (human) ]

Gene ID: 145645, updated on 11-Jun-2022

Summary

Official Symbol
TERB2provided by HGNC
Official Full Name
telomere repeat binding bouquet formation protein 2provided by HGNC
Primary source
HGNC:HGNC:28520
See related
Ensembl:ENSG00000167014 MIM:617131; AllianceGenome:HGNC:28520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPGF59; C15orf43
Summary
Predicted to be involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Predicted to be located in chromosome, telomeric region. Predicted to be active in nuclear inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 12.0) See more
Orthologs
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Genomic context

See TERB2 in Genome Data Viewer
Location:
15q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (44956687..44979229)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (42764694..42787237)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (45248885..45271427)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene telomere repeat binding bouquet formation protein 2 pseudogene Neighboring gene 5-azacytidine induced 2 pseudogene Neighboring gene RNA, U6 small nuclear 1108, pseudogene Neighboring gene RNA, U6 small nuclear 1332, pseudogene Neighboring gene 5-azacytidine induced 2 pseudogene Neighboring gene RNA, U6 small nuclear 966, pseudogene Neighboring gene RNA, U1 small nuclear 78, pseudogene Neighboring gene Sharpr-MPRA regulatory region 12640 Neighboring gene sorbitol dehydrogenase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33951

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in homologous chromosome pairing at meiosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic attachment of telomere to nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic attachment of telomere to nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic telomere clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
telomere repeats-binding bouquet formation protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152448.3NP_689661.1  telomere repeats-binding bouquet formation protein 2

    See identical proteins and their annotated locations for NP_689661.1

    Status: VALIDATED

    Source sequence(s)
    AC090888, BC029537
    Consensus CDS
    CCDS10115.1
    UniProtKB/Swiss-Prot
    Q8NHR7
    Related
    ENSP00000340644.3, ENST00000340827.4
    Conserved Domains (1) summary
    pfam15101
    Location:2205
    DUF4557; Domain of unknown function (DUF4557)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    44956687..44979229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521240.3XP_011519542.1  telomere repeats-binding bouquet formation protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15101
    Location:2116
    DUF4557; Domain of unknown function (DUF4557)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    42764694..42787237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)