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TERB2 telomere repeat binding bouquet formation protein 2 [ Homo sapiens (human) ]

Gene ID: 145645, updated on 5-Jul-2025
Official Symbol
TERB2provided by HGNC
Official Full Name
telomere repeat binding bouquet formation protein 2provided by HGNC
Primary source
HGNC:HGNC:28520
See related
Ensembl:ENSG00000167014 MIM:617131; AllianceGenome:HGNC:28520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPGF59; C15orf43
Summary
Predicted to be involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Predicted to act upstream of or within meiosis I; oogenesis; and spermatogenesis. Predicted to be located in chromosome, telomeric region. Predicted to be active in nuclear inner membrane. Implicated in spermatogenic failure 59. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Restricted expression toward testis (RPKM 12.0) See more
Orthologs
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See TERB2 in Genome Data Viewer
Location:
15q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (44956687..44979229)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (42764694..42787237)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (45248885..45271427)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene telomere repeat binding bouquet formation protein 2 pseudogene Neighboring gene 5-azacytidine induced 2 pseudogene Neighboring gene RNA, U6 small nuclear 1108, pseudogene Neighboring gene RNA, U6 small nuclear 1332, pseudogene Neighboring gene 5-azacytidine induced 2 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr15:45264252-45264430 Neighboring gene MPRA-validated peak2324 silencer Neighboring gene RNA, U6 small nuclear 966, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9348 Neighboring gene RNA, U1 small nuclear 78, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6399 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:45316112-45316762 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:45317906-45318194 Neighboring gene Sharpr-MPRA regulatory region 12640 Neighboring gene sorbitol dehydrogenase Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta pseudogene

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC33951

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within double-strand break repair involved in meiotic recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in homologous chromosome pairing at meiosis IEA
Inferred from Electronic Annotation
more info
 
involved_in homologous chromosome pairing at meiosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic attachment of telomere to nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in meiotic attachment of telomere to nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic attachment of telomere to nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic telomere clustering IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic telomere clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within oogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within synaptonemal complex assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
telomere repeats-binding bouquet formation protein 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152448.3NP_689661.1  telomere repeats-binding bouquet formation protein 2

    See identical proteins and their annotated locations for NP_689661.1

    Status: VALIDATED

    Source sequence(s)
    AC090888, BC029537
    Consensus CDS
    CCDS10115.1
    UniProtKB/Swiss-Prot
    Q8NHR7
    Related
    ENSP00000340644.3, ENST00000340827.4
    Conserved Domains (1) summary
    pfam15101
    Location:2205
    DUF4557; Domain of unknown function (DUF4557)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    44956687..44979229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521240.3XP_011519542.1  telomere repeats-binding bouquet formation protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15101
    Location:2116
    DUF4557; Domain of unknown function (DUF4557)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    42764694..42787237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377309.1XP_054233284.1  telomere repeats-binding bouquet formation protein 2 isoform X1