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Terb2 telomere repeat binding bouquet formation protein 2 [ Mus musculus (house mouse) ]

Gene ID: 74401, updated on 8-Feb-2024

Summary

Official Symbol
Terb2provided by MGI
Official Full Name
telomere repeat binding bouquet formation protein 2provided by MGI
Primary source
MGI:MGI:1921651
See related
Ensembl:ENSMUSG00000027229 AllianceGenome:MGI:1921651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933406J08Rik
Summary
Involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Located in chromosome, telomeric region and nuclear inner membrane. Orthologous to human TERB2 (telomere repeat binding bouquet formation protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Terb2 in Genome Data Viewer
Location:
2 E5; 2 60.56 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122016753..122036874)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122186272..122206393)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene protein associated with topoisomerase II homolog 2 (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E512 Neighboring gene STARR-seq mESC enhancer starr_05550 Neighboring gene beta-2 microglobulin Neighboring gene tripartite motif-containing 69 Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial pseudogene Neighboring gene predicted gene 14058

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within double-strand break repair involved in meiotic recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within double-strand break repair involved in meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic attachment of telomere to nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic attachment of telomere to nuclear envelope IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic telomere clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
telomere repeats-binding bouquet formation protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028914.1NP_083190.1  telomere repeats-binding bouquet formation protein 2

    See identical proteins and their annotated locations for NP_083190.1

    Status: VALIDATED

    Source sequence(s)
    AK016695, AL844573
    Consensus CDS
    CCDS50688.1
    UniProtKB/Swiss-Prot
    Q9D494
    UniProtKB/TrEMBL
    A0A0P0YTB2
    Related
    ENSMUSP00000028661.6, ENSMUST00000028661.6
    Conserved Domains (1) summary
    pfam15101
    Location:2202
    DUF4557; Domain of unknown function (DUF4557)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    122016753..122036874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)