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Gdf11 growth differentiation factor 11 [ Mus musculus (house mouse) ]

Gene ID: 14561, updated on 31-Jan-2019

Summary

Official Symbol
Gdf11provided by MGI
Official Full Name
growth differentiation factor 11provided by MGI
Primary source
MGI:MGI:1338027
See related
Ensembl:ENSMUSG00000025352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bmp11; BMP-11
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. Mice lacking a functional copy of this gene exhibit impaired anteroposterior patterning and other developmental defects. [provided by RefSeq, Aug 2016]
Expression
Broad expression in CNS E11.5 (RPKM 8.5), whole brain E14.5 (RPKM 5.3) and 23 other tissues See more
Orthologs

Genomic context

See Gdf11 in Genome Data Viewer
Location:
10; 10 D3
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (128884546..128891718, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (128321602..128328774, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C14 Neighboring gene ORM1-like 2 (S. cerevisiae) Neighboring gene SAP domain containing ribonucleoprotein Neighboring gene CD63 antigen Neighboring gene retinol dehydrogenase 5 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephros development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
roof of mouth development IGI
Inferred from Genetic Interaction
more info
PubMed 
skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
spinal cord anterior/posterior patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
growth/differentiation factor 11
Names
GDF-11
bone morphogenetic protein 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010272.2NP_034402.1  growth/differentiation factor 11 preproprotein

    See identical proteins and their annotated locations for NP_034402.1

    Status: REVIEWED

    Source sequence(s)
    AC122380
    Consensus CDS
    CCDS24296.1
    UniProtKB/Swiss-Prot
    Q9Z1W4
    Related
    ENSMUSP00000026408.6, ENSMUST00000026408.6
    Conserved Domains (2) summary
    smart00204
    Location:311405
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:59283
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

    Range
    128884546..128891718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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