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CSN3 casein kappa [ Homo sapiens (human) ]

Gene ID: 1448, updated on 25-Jan-2022

Summary

Official Symbol
CSN3provided by HGNC
Official Full Name
casein kappaprovided by HGNC
Primary source
HGNC:HGNC:2446
See related
Ensembl:ENSG00000171209 MIM:601695; AllianceGenome:HGNC:2446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KCA; CSNK; CNS10; CSN10
Summary
Involved in lactation and protein stabilization. Located in extracellular space. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward salivary gland (RPKM 13.6) See more
Orthologs
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Genomic context

See CSN3 in Genome Data Viewer
Location:
4q13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (70238381..70251432)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71104098..71117149)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene odontogenic, ameloblast associated Neighboring gene follicular dendritic cell secreted protein Neighboring gene calcium binding protein, spermatid associated 1 Neighboring gene submaxillary gland androgen regulated protein 3A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in lactation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lactation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394997.1NP_001381926.1  kappa-casein precursor

    Status: VALIDATED

    Source sequence(s)
    AC105347
    Related
    ENSP00000304822.3, ENST00000304954.4
    Conserved Domains (1) summary
    pfam00997
    Location:21171
    Casein_kappa; Kappa casein
  2. NM_005212.3NP_005203.2  kappa-casein precursor

    See identical proteins and their annotated locations for NP_005203.2

    Status: VALIDATED

    Source sequence(s)
    AC105347, BG191674, X66417
    Consensus CDS
    CCDS3538.1
    UniProtKB/Swiss-Prot
    P07498
    Conserved Domains (1) summary
    pfam00997
    Location:21171
    Casein_kappa; Kappa casein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    70238381..70251432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007761.1XP_016863250.1  kappa-casein isoform X1

    UniProtKB/Swiss-Prot
    P07498
    Related
    ENSP00000508633.1, ENST00000689459.1
    Conserved Domains (1) summary
    pfam00997
    Location:21171
    Casein_kappa; Kappa casein
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