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Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 [ Mus musculus (house mouse) ]

Gene ID: 14396, updated on 11-Apr-2024

Summary

Official Symbol
Gabra3provided by MGI
Official Full Name
gamma-aminobutyric acid type A receptor subunit alpha 3provided by MGI
Primary source
MGI:MGI:95615
See related
Ensembl:ENSMUSG00000031343 AllianceGenome:MGI:95615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gabra-3
Summary
Enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within ion transport. Located in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in bipolar disorder and multiple sclerosis. Orthologous to human GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 17.8), cortex adult (RPKM 14.7) and 10 other tissues See more
Orthologs
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Genomic context

See Gabra3 in Genome Data Viewer
Location:
X A7.3; X 37.24 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (71476282..71700525, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (72432676..72656919, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene microRNA 452 Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit epsilon Neighboring gene STARR-seq mESC enhancer starr_47334 Neighboring gene MAGE family member A10 Neighboring gene coiled-coil domain containing 99 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47335 Neighboring gene STARR-seq mESC enhancer starr_47336 Neighboring gene STARR-seq mESC enhancer starr_47337 Neighboring gene microRNA 767 Neighboring gene microRNA 105 Neighboring gene predicted gene, 23461 Neighboring gene STARR-seq mESC enhancer starr_47338 Neighboring gene predicted gene, 57671 Neighboring gene STARR-seq mESC enhancer starr_47339 Neighboring gene gamma-aminobutyric acid type A receptor subunit theta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to GABA-A receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GABA-A receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables GABA-gated chloride ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GABA-gated chloride ion channel activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to benzodiazepine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential EXP
Inferred from Experiment
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in inhibitory synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in GABA-ergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
gamma-aminobutyric acid receptor subunit alpha-3
Names
GABA(A) receptor subunit alpha-3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357814.1NP_001344743.1  gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL731695, BX119994
    Consensus CDS
    CCDS30187.1
    UniProtKB/Swiss-Prot
    P26049
    UniProtKB/TrEMBL
    Q8CAB3
    Related
    ENSMUSP00000110201.3, ENSMUST00000114554.3
    Conserved Domains (2) summary
    TIGR00860
    Location:69478
    LIC; Cation transporter family protein
    cd19036
    Location:75274
    LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)
  2. NM_001357815.1NP_001344744.1  gamma-aminobutyric acid receptor subunit alpha-3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL731695, BX119994
    UniProtKB/TrEMBL
    Q8CAB3
    Conserved Domains (1) summary
    cl27321
    Location:83492
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
  3. NM_001357816.1NP_001344745.1  gamma-aminobutyric acid receptor subunit alpha-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL731695, BX119994
    UniProtKB/TrEMBL
    B1AVY2
    Conserved Domains (1) summary
    cl27321
    Location:100509
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
  4. NM_001358103.1NP_001345032.1  gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL731695, BX119994
    Consensus CDS
    CCDS30187.1
    UniProtKB/Swiss-Prot
    P26049
    UniProtKB/TrEMBL
    Q8CAB3
    Conserved Domains (2) summary
    TIGR00860
    Location:69478
    LIC; Cation transporter family protein
    cd19036
    Location:75274
    LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)
  5. NM_008067.4NP_032093.3  gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032093.3

    Status: VALIDATED

    Source sequence(s)
    AK039144, AK134760, AL731695, BX119994, CD354278
    Consensus CDS
    CCDS30187.1
    UniProtKB/Swiss-Prot
    P26049
    UniProtKB/TrEMBL
    Q8CAB3
    Related
    ENSMUSP00000062638.7, ENSMUST00000055966.13
    Conserved Domains (2) summary
    TIGR00860
    Location:69478
    LIC; Cation transporter family protein
    cd19036
    Location:75274
    LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    71476282..71700525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161818.1XP_036017711.1  gamma-aminobutyric acid receptor subunit alpha-3 isoform X1

    UniProtKB/Swiss-Prot
    P26049
    UniProtKB/TrEMBL
    Q8CAB3
    Conserved Domains (2) summary
    TIGR00860
    Location:69478
    LIC; Cation transporter family protein
    cd19036
    Location:75274
    LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)