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XRRA1 X-ray radiation resistance associated 1 [ Homo sapiens (human) ]

Gene ID: 143570, updated on 5-Jan-2022

Summary

Official Symbol
XRRA1provided by HGNC
Official Full Name
X-ray radiation resistance associated 1provided by HGNC
Primary source
HGNC:HGNC:18868
See related
Ensembl:ENSG00000166435 MIM:609788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Involved in response to X-ray. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in testis (RPKM 10.6), thyroid (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

See XRRA1 in Genome Data Viewer
Location:
11q13.4
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (74840910..74949187, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74551955..74660136, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNF169 intron CAGE-defined mid-level expression enhancer Neighboring gene ribosomal protein S12 pseudogene 22 Neighboring gene ring finger protein 169 Neighboring gene RNA, 7SL, cytoplasmic 239, pseudogene Neighboring gene uncharacterized LOC107984352 Neighboring gene ribosomal protein L31 pseudogene 46 Neighboring gene signal peptidase complex subunit 2 Neighboring gene RNA, U6 small nuclear 216, pseudogene Neighboring gene neuraminidase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in response to X-ray IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
X-ray radiation resistance-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270380.3NP_001257309.1  X-ray radiation resistance-associated protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001257309.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple exons in the 3' coding region, compared to variant, which results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AP000560, AP001992
    Consensus CDS
    CCDS58160.1
    UniProtKB/Swiss-Prot
    Q6P2D8
    UniProtKB/TrEMBL
    Q8TEH2
    Related
    ENSP00000435838.1, ENST00000527087.5
    Conserved Domains (3) summary
    cd00116
    Location:134265
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:142164
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:140199
    LRR_8; Leucine rich repeat
  2. NM_001270381.3NP_001257310.1  X-ray radiation resistance-associated protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AP000560, AP001992
    Consensus CDS
    CCDS58159.1
    UniProtKB/Swiss-Prot
    Q6P2D8
    UniProtKB/TrEMBL
    Q8TEH2
    Related
    ENSP00000319303.8, ENST00000321448.12
  3. NM_001378157.1NP_001365086.1  X-ray radiation resistance-associated protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AP000560, AP001992
    Related
    ENSP00000507107.1, ENST00000684022.1
    Conserved Domains (2) summary
    COG4886
    Location:116320
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:150172
    LRR_RI; leucine-rich repeat [structural motif]
  4. NM_001378158.1NP_001365087.1  X-ray radiation resistance-associated protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AP000560, AP001992
    Conserved Domains (2) summary
    COG4886
    Location:116320
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:150172
    LRR_RI; leucine-rich repeat [structural motif]
  5. NM_001378159.1NP_001365088.1  X-ray radiation resistance-associated protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AP000560, AP001992
    Conserved Domains (2) summary
    COG4886
    Location:116320
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:150172
    LRR_RI; leucine-rich repeat [structural motif]
  6. NM_001378160.1NP_001365089.1  X-ray radiation resistance-associated protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AP000560, AP001992
    Conserved Domains (2) summary
    COG4886
    Location:116320
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:150172
    LRR_RI; leucine-rich repeat [structural motif]
  7. NM_001378161.1NP_001365090.1  X-ray radiation resistance-associated protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AP000560, AP001992
  8. NM_001378162.1NP_001365091.1  X-ray radiation resistance-associated protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AP000560, AP001992
  9. NM_001378163.1NP_001365092.1  X-ray radiation resistance-associated protein 1 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform 10.
    Source sequence(s)
    AP000560, AP001992
  10. NM_001378164.1NP_001365093.1  X-ray radiation resistance-associated protein 1 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform 10.
    Source sequence(s)
    AP000560, AP001992
  11. NM_001378165.1NP_001365094.1  X-ray radiation resistance-associated protein 1 isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform 11.
    Source sequence(s)
    AP000560, AP001992
  12. NM_001378166.1NP_001365095.1  X-ray radiation resistance-associated protein 1 isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform 11.
    Source sequence(s)
    AP000560, AP001992
  13. NM_001378167.1NP_001365096.1  X-ray radiation resistance-associated protein 1 isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform 11.
    Source sequence(s)
    AP000560, AP001992
  14. NM_001378168.1NP_001365097.1  X-ray radiation resistance-associated protein 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AP000560, AP001992
  15. NM_001378169.1NP_001365098.1  X-ray radiation resistance-associated protein 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AP000560, AP001992
  16. NM_001378170.1NP_001365099.1  X-ray radiation resistance-associated protein 1 isoform 14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variant 18, encodes isoform 14.
    Source sequence(s)
    AP000560, AP001992
  17. NM_001378171.1NP_001365100.1  X-ray radiation resistance-associated protein 1 isoform 14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variant 17, encodes isoform 14.
    Source sequence(s)
    AP000560, AP001992
  18. NM_001378172.1NP_001365101.1  X-ray radiation resistance-associated protein 1 isoform 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variant 20, encodes isoform 15.
    Source sequence(s)
    AP000560, AP001992
  19. NM_001378173.1NP_001365102.1  X-ray radiation resistance-associated protein 1 isoform 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variant 19, encodes isoform 15.
    Source sequence(s)
    AP000560, AP001992
  20. NM_001378174.1NP_001365103.1  X-ray radiation resistance-associated protein 1 isoform 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21), as well as variants 22 and 23, encodes isoform 16.
    Source sequence(s)
    AP000560, AP001992
  21. NM_001378175.1NP_001365104.1  X-ray radiation resistance-associated protein 1 isoform 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22), as well as variants 21 and 23, encodes isoform 16.
    Source sequence(s)
    AP000560, AP001992
  22. NM_001378176.1NP_001365105.1  X-ray radiation resistance-associated protein 1 isoform 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23), as well as variants 21 and 22, encodes isoform 16.
    Source sequence(s)
    AP000560, AP001992
  23. NM_182969.4NP_892014.1  X-ray radiation resistance-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_892014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AP000560, AP001992
    Consensus CDS
    CCDS44680.1
    UniProtKB/Swiss-Prot
    Q6P2D8
    UniProtKB/TrEMBL
    Q8TEH2
    Related
    ENSP00000339918.6, ENST00000340360.10
    Conserved Domains (3) summary
    cd00116
    Location:134265
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:142164
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:140199
    LRR_8; Leucine rich repeat

RNA

  1. NR_165434.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000560, AP001992
  2. NR_165435.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000560, AP001992
  3. NR_165436.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000560, AP001992
    Related
    ENST00000531849.5
  4. NR_165437.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000560, AP001992
  5. NR_165438.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000560, AP001992
  6. NR_165439.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000560, AP001992

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    74840910..74949187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017223.2XP_016872712.1  X-ray radiation resistance-associated protein 1 isoform X16

  2. XM_017017224.2XP_016872713.1  X-ray radiation resistance-associated protein 1 isoform X17

    Conserved Domains (2) summary
    COG4886
    Location:116320
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:150172
    LRR_RI; leucine-rich repeat [structural motif]
  3. XM_017017222.2XP_016872711.1  X-ray radiation resistance-associated protein 1 isoform X14

  4. XM_011544763.2XP_011543065.1  X-ray radiation resistance-associated protein 1 isoform X11

    Conserved Domains (3) summary
    cd00116
    Location:142273
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:150172
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:148207
    LRR_8; Leucine rich repeat
  5. XM_024448354.1XP_024304122.1  X-ray radiation resistance-associated protein 1 isoform X24

  6. XM_017017228.2XP_016872717.1  X-ray radiation resistance-associated protein 1 isoform X19

  7. XM_011544761.1XP_011543063.1  X-ray radiation resistance-associated protein 1 isoform X9

    Conserved Domains (2) summary
    COG4886
    Location:95196
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:95115
    LRR_1; leucine-rich repeat [structural motif]
  8. XM_011544759.1XP_011543061.1  X-ray radiation resistance-associated protein 1 isoform X6

    Conserved Domains (3) summary
    cd00116
    Location:105208
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:110131
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:130208
    LRR_8; Leucine rich repeat
  9. XM_011544758.1XP_011543060.1  X-ray radiation resistance-associated protein 1 isoform X5

    Conserved Domains (3) summary
    cd00116
    Location:119216
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:117139
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:138216
    LRR_8; Leucine rich repeat
  10. XM_011544762.1XP_011543064.1  X-ray radiation resistance-associated protein 1 isoform X10

    Conserved Domains (3) summary
    cd00116
    Location:142273
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:150172
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:148207
    LRR_8; Leucine rich repeat
  11. XM_011544757.1XP_011543059.1  X-ray radiation resistance-associated protein 1 isoform X4

    Conserved Domains (3) summary
    cd00116
    Location:142273
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:150172
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:148207
    LRR_8; Leucine rich repeat
  12. XM_011544756.1XP_011543058.1  X-ray radiation resistance-associated protein 1 isoform X3

    Conserved Domains (3) summary
    cd00116
    Location:142273
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:150172
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:148207
    LRR_8; Leucine rich repeat
  13. XM_017017221.1XP_016872710.1  X-ray radiation resistance-associated protein 1 isoform X8

  14. XM_011544755.1XP_011543057.1  X-ray radiation resistance-associated protein 1 isoform X2

    Conserved Domains (2) summary
    COG4886
    Location:116320
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:150172
    LRR_RI; leucine-rich repeat [structural motif]
  15. XM_017017227.1XP_016872716.1  X-ray radiation resistance-associated protein 1 isoform X13

  16. XM_011544767.1XP_011543069.1  X-ray radiation resistance-associated protein 1 isoform X15

    See identical proteins and their annotated locations for XP_011543069.1

    Conserved Domains (2) summary
    sd00033
    Location:7599
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:73118
    LRR_4; Leucine Rich repeats (2 copies)
  17. XM_017017230.2XP_016872719.1  X-ray radiation resistance-associated protein 1 isoform X21

  18. XM_017017226.2XP_016872715.1  X-ray radiation resistance-associated protein 1 isoform X13

  19. XM_005273770.2XP_005273827.1  X-ray radiation resistance-associated protein 1 isoform X13

    See identical proteins and their annotated locations for XP_005273827.1

  20. XM_011544766.3XP_011543068.1  X-ray radiation resistance-associated protein 1 isoform X15

    See identical proteins and their annotated locations for XP_011543068.1

    Conserved Domains (2) summary
    sd00033
    Location:7599
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:73118
    LRR_4; Leucine Rich repeats (2 copies)
  21. XM_011544768.1XP_011543070.1  X-ray radiation resistance-associated protein 1 isoform X15

    See identical proteins and their annotated locations for XP_011543070.1

    Conserved Domains (2) summary
    sd00033
    Location:7599
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:73118
    LRR_4; Leucine Rich repeats (2 copies)
  22. XM_011544765.1XP_011543067.1  X-ray radiation resistance-associated protein 1 isoform X13

    See identical proteins and their annotated locations for XP_011543067.1

  23. XM_011544760.2XP_011543062.1  X-ray radiation resistance-associated protein 1 isoform X7

    Conserved Domains (3) summary
    cd00116
    Location:142273
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:150172
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:148207
    LRR_8; Leucine rich repeat
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