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CSE1L chromosome segregation 1 like [ Homo sapiens (human) ]

Gene ID: 1434, updated on 3-May-2020

Summary

Official Symbol
CSE1Lprovided by HGNC
Official Full Name
chromosome segregation 1 likeprovided by HGNC
Primary source
HGNC:HGNC:2431
See related
Ensembl:ENSG00000124207 MIM:601342
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAS; CSE1; XPO2
Summary
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Broad expression in testis (RPKM 57.6), esophagus (RPKM 21.5) and 24 other tissues See more
Orthologs

Genomic context

See CSE1L in Genome Data Viewer
Location:
20q13.13
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (49046246..49096960)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (47662783..47713497)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene CSE1L antisense RNA 1 Neighboring gene synaptosome associated protein 23 pseudogene 1 Neighboring gene staufen double-stranded RNA binding protein 1 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 1 Neighboring gene DEAD-box helicase 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates chromosome segregation 1-like (yeast) in HEK 293T cells PubMed
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies nuclear import-export proteins Exp2 and RanBP9 as IN-binding partners PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117283, MGC130036, MGC130037

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ran GTPase binding IEA
Inferred from Electronic Annotation
more info
 
nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
exportin-2
Names
CSE1 chromosome segregation 1-like
cellular apoptosis susceptibility protein
chromosome segregation 1-like protein
epididymis secretory sperm binding protein
exp2
importin-alpha re-exporter

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256135.1NP_001243064.1  exportin-2 isoform 2

    See identical proteins and their annotated locations for NP_001243064.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AI018123, AI973168, BC109314, DC402014, EF426455
    Consensus CDS
    CCDS58773.1
    UniProtKB/Swiss-Prot
    P55060
    Related
    ENSP00000379495.3, ENST00000396192.7
    Conserved Domains (3) summary
    smart00913
    Location:29102
    IBN_N; Importin-beta N-terminal domain
    pfam03378
    Location:471906
    CAS_CSE1; CAS/CSE protein, C-terminus
    cl27876
    Location:156469
    Cse1; Cse1
  2. NM_001316.4NP_001307.2  exportin-2 isoform 1

    See identical proteins and their annotated locations for NP_001307.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AI018123, AI973168, BC109314, DC402014
    Consensus CDS
    CCDS13412.1
    UniProtKB/Swiss-Prot
    P55060
    Related
    ENSP00000262982.2, ENST00000262982.3
    Conserved Domains (3) summary
    smart00913
    Location:29102
    IBN_N; Importin-beta N-terminal domain
    pfam08506
    Location:156525
    Cse1; Cse1
    pfam03378
    Location:527962
    CAS_CSE1; CAS/CSE protein, C-terminus
  3. NM_001362762.2NP_001349691.1  exportin-2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL121903, AL133174
    Conserved Domains (3) summary
    smart00913
    Location:29102
    IBN_N; Importin-beta N-terminal domain
    pfam08506
    Location:156525
    Cse1; Cse1
    pfam03378
    Location:527942
    CAS_CSE1; CAS/CSE protein, C-terminus

RNA

  1. NR_045796.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks 3 consecutive exons, and uses alternate splice sites at 2 other exons compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon (with a strong Kozak signal), as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI018123, AI973168, AK300589, BC109314, DC402014

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    49046246..49096960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177436.1: Suppressed sequence

    Description
    NM_177436.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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