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PARP4 poly(ADP-ribose) polymerase family member 4 [ Homo sapiens (human) ]

Gene ID: 143, updated on 5-Apr-2020

Summary

Official Symbol
PARP4provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 4provided by HGNC
Primary source
HGNC:HGNC:271
See related
Ensembl:ENSG00000102699 MIM:607519
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PH5P; p193; ARTD4; PARPL; VPARP; VWA5C; PARP-4; VAULT3; ADPRTL1
Summary
This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 22.5), small intestine (RPKM 20.2) and 25 other tissues See more
Orthologs

Genomic context

See PARP4 in Genome Data Viewer
Location:
13q12.12
Exon count:
36
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (24420930..24512993, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (24995069..25086948, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 566 Neighboring gene NUS1 pseudogene 3 Neighboring gene CYCS pseudogene 33 Neighboring gene uncharacterized LOC105370117 Neighboring gene uncharacterized LOC105370295 Neighboring gene ankyrin repeat domain-containing protein 26-like Neighboring gene paraspeckle component 1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with poly (ADP-ribose) polymerase family, member 4 (PARP4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
gag-pol Inhibition of HIV-1 protease by saquinavir and leu3.a blocks PARP cleavage and protects cells from apoptosis and necrosis PubMed
gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells, which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD+ ADP-ribosyltransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein modification process IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus NAS
Non-traceable Author Statement
more info
PubMed 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ADP-ribosylation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of telomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
response to drug NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
ribonucleoprotein complex NAS
Non-traceable Author Statement
more info
PubMed 
spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP4
Names
193 kDa vault protein
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1
ADP-ribosyltransferase diphtheria toxin-like 4
H5 proline-rich
I-alpha-I-related
PARP-related
PARP-related/IalphaI-related H5/proline-rich
poly [ADP-ribose] polymerase 4
poly(ADP-ribose) synthetase
poly(ADP-ribosyl)transferase-like 1
vault poly(ADP-ribose) polymerase
vault protein, 193-kDa
von Willebrand factor A domain containing 5C
NP_006428.2
XP_011533233.1
XP_011533234.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006437.4NP_006428.2  protein mono-ADP-ribosyltransferase PARP4

    See identical proteins and their annotated locations for NP_006428.2

    Status: REVIEWED

    Source sequence(s)
    AF158255, AL359763, BX479127, CA308288, CV574448, DB238428, T10289
    Consensus CDS
    CCDS9307.1
    UniProtKB/Swiss-Prot
    Q9UKK3
    Related
    ENSP00000371419.3, ENST00000381989.4
    Conserved Domains (6) summary
    smart00327
    Location:8771033
    VWA; von Willebrand factor (vWF) type A domain
    cd01437
    Location:251565
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    TIGR03788
    Location:6361184
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam00533
    Location:181
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam00644
    Location:378565
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam08487
    Location:623731
    VIT; Vault protein inter-alpha-trypsin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    24420930..24512993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534931.1XP_011533233.1  protein mono-ADP-ribosyltransferase PARP4 isoform X1

    Conserved Domains (5) summary
    smart00327
    Location:9241080
    VWA; von Willebrand factor (vWF) type A domain
    cd01437
    Location:298612
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    TIGR03788
    Location:6831231
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam00644
    Location:425612
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam08487
    Location:670778
    VIT; Vault protein inter-alpha-trypsin domain
  2. XM_011534932.2XP_011533234.1  protein mono-ADP-ribosyltransferase PARP4 isoform X2

    See identical proteins and their annotated locations for XP_011533234.1

    UniProtKB/Swiss-Prot
    Q9UKK3
    Conserved Domains (6) summary
    smart00327
    Location:8771033
    VWA; von Willebrand factor (vWF) type A domain
    cd01437
    Location:251565
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    TIGR03788
    Location:6361184
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam00533
    Location:181
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam00644
    Location:378565
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam08487
    Location:623731
    VIT; Vault protein inter-alpha-trypsin domain

RNA

  1. XR_941496.1 RNA Sequence

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