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Frat1 frequently rearranged in advanced T cell lymphomas [ Mus musculus (house mouse) ]

Gene ID: 14296, updated on 8-Feb-2024

Summary

Official Symbol
Frat1provided by MGI
Official Full Name
frequently rearranged in advanced T cell lymphomasprovided by MGI
Primary source
MGI:MGI:109450
See related
Ensembl:ENSMUSG00000067199 AllianceGenome:MGI:109450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Acts upstream of or within embryonic axis specification and protein export from nucleus. Located in cytoplasm and nucleus. Is expressed in several structures, including bronchiole; central nervous system; gut; hemolymphoid system gland; and sensory organ. Orthologous to human FRAT1 (FRAT regulator of WNT signaling pathway 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Frat1 in Genome Data Viewer
Location:
19 C3; 19 35.3 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41818409..41821022)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41829970..41832583)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46160 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:41843349-41843458 Neighboring gene Rho GTPase activating protein 19 Neighboring gene STARR-seq mESC enhancer starr_46161 Neighboring gene predicted gene, 41847 Neighboring gene STARR-positive B cell enhancer ABC_E7656 Neighboring gene STARR-positive B cell enhancer ABC_E7657 Neighboring gene STARR-seq mESC enhancer starr_46163 Neighboring gene STARR-positive B cell enhancer mm9_chr19:41922780-41923081 Neighboring gene frequently rearranged in advanced T cell lymphomas 2 Neighboring gene ribosomal RNA processing 12 homolog Neighboring gene STARR-positive B cell enhancer ABC_E4281

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proto-oncogene FRAT1
Names
frequently rearranged in advanced T-cell lymphomas 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008043.3NP_032069.2  proto-oncogene FRAT1

    See identical proteins and their annotated locations for NP_032069.2

    Status: VALIDATED

    Source sequence(s)
    AC145557
    Consensus CDS
    CCDS84438.1
    UniProtKB/Swiss-Prot
    P70339
    UniProtKB/TrEMBL
    B2RU64
    Related
    ENSMUSP00000147726.2, ENSMUST00000087155.5
    Conserved Domains (1) summary
    pfam05350
    Location:1233
    GSK-3_bind; Glycogen synthase kinase-3 binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    41818409..41821022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)