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FRAT1 FRAT regulator of WNT signaling pathway 1 [ Homo sapiens (human) ]

Gene ID: 10023, updated on 1-Jun-2020

Summary

Official Symbol
FRAT1provided by HGNC
Official Full Name
FRAT regulator of WNT signaling pathway 1provided by HGNC
Primary source
HGNC:HGNC:3944
See related
Ensembl:ENSG00000165879 MIM:602503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]
Orthologs

Genomic context

See FRAT1 in Genome Data Viewer
Location:
10q24.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (97319271..97321915)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99079022..99081672)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ARHGAP19-SLIT1 readthrough (NMD candidate) Neighboring gene uncharacterized LOC105378447 Neighboring gene Rho GTPase activating protein 19 Neighboring gene ribosomal protein L12 pseudogene 27 Neighboring gene uncharacterized LOC105378448 Neighboring gene FRAT regulator of WNT signaling pathway 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ97193

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
proto-oncogene FRAT1
Names
FRAT-1
FRAT1, WNT signaling pathway regulator
frequently rearranged in advanced T-cell lymphomas 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005479.4NP_005470.2  proto-oncogene FRAT1

    See identical proteins and their annotated locations for NP_005470.2

    Status: REVIEWED

    Source sequence(s)
    AL355490
    Consensus CDS
    CCDS7455.1
    UniProtKB/Swiss-Prot
    Q92837
    Related
    ENSP00000360060.3, ENST00000371021.5
    Conserved Domains (1) summary
    pfam05350
    Location:1239
    GSK-3_bind; Glycogen synthase kinase-3 binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    97319271..97321915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181355.1: Suppressed sequence

    Description
    NM_181355.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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