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CRYZ crystallin zeta [ Homo sapiens (human) ]

Gene ID: 1429, updated on 7-Dec-2018

Summary

Official Symbol
CRYZprovided by HGNC
Official Full Name
crystallin zetaprovided by HGNC
Primary source
HGNC:HGNC:2419
See related
Ensembl:ENSG00000116791 MIM:123691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]
Expression
Broad expression in kidney (RPKM 99.6), liver (RPKM 48.8) and 23 other tissues See more
Orthologs

Genomic context

See CRYZ in Genome Data Viewer
Location:
1p31.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (74705470..74733408, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (75171170..75199092, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene FPGT-TNNI3K readthrough Neighboring gene TNNI3 interacting kinase Neighboring gene uncharacterized LOC105378805 Neighboring gene leucine rich repeat containing 53 Neighboring gene ERICH3 antisense RNA 1 Neighboring gene glutamate rich 3 Neighboring gene tRNA-yW synthesizing protein 3 homolog Neighboring gene RNA, U6 small nuclear 622, pseudogene Neighboring gene LIM homeobox 8 Neighboring gene solute carrier family 44 member 5 Neighboring gene G protein nucleolar 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of crystallin, zeta (CRYZ; quinone reductase) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41475, DKFZp779E0834

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT NADH binding IDA
Inferred from Direct Assay
more info
PubMed 
NADPH binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADPH binding IDA
Inferred from Direct Assay
more info
PubMed 
NADPH:quinone reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADPH:quinone reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein homotetramerization IPI
Inferred from Physical Interaction
more info
PubMed 
visual perception TAS
Traceable Author Statement
more info
PubMed 
xenobiotic catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
quinone oxidoreductase
Names
NADPH:quinone reductase
crystallin, zeta (quinone reductase)
epididymis secretory sperm binding protein
NP_001123514.1
NP_001123515.1
NP_001128231.1
NP_001880.2
XP_005270548.1
XP_011539049.1
XP_016855856.1
XP_016855857.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029880.1 RefSeqGene

    Range
    5001..32923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130042.1NP_001123514.1  quinone oxidoreductase isoform a

    See identical proteins and their annotated locations for NP_001123514.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AC091611, BC039578, BC070058, CN368109, DA256305
    Consensus CDS
    CCDS665.1
    UniProtKB/Swiss-Prot
    Q08257
    Related
    ENSP00000399805.1, ENST00000417775.5
    Conserved Domains (2) summary
    cd08253
    Location:8329
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
    COG0604
    Location:8327
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
  2. NM_001130043.1NP_001123515.1  quinone oxidoreductase isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC091611, AK314813, BC039578, CN368109, DA256305
    Consensus CDS
    CCDS44162.1
    UniProtKB/Swiss-Prot
    Q08257
    Related
    ENSP00000359908.3, ENST00000370871.7
    Conserved Domains (2) summary
    cd08253
    Location:8295
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
    COG0604
    Location:8293
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
  3. NM_001134759.1NP_001128231.1  quinone oxidoreductase isoform c

    See identical proteins and their annotated locations for NP_001128231.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and CDS compard to variant 1. The resulting isoform (c) has a different and much shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC091611, BC039578, BX647883
    Consensus CDS
    CCDS44163.1
    UniProtKB/Swiss-Prot
    Q08257
    Related
    ENSP00000359909.3, ENST00000370872.7
    Conserved Domains (2) summary
    cd08253
    Location:3192
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
    COG0604
    Location:9190
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
  4. NM_001889.4NP_001880.2  quinone oxidoreductase isoform a

    See identical proteins and their annotated locations for NP_001880.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    BC039578, DA256305
    Consensus CDS
    CCDS665.1
    UniProtKB/Swiss-Prot
    Q08257
    Related
    ENSP00000339399.5, ENST00000340866.9
    Conserved Domains (2) summary
    cd08253
    Location:8329
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
    COG0604
    Location:8327
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    74705470..74733408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540747.2XP_011539049.1  quinone oxidoreductase isoform X1

    See identical proteins and their annotated locations for XP_011539049.1

    UniProtKB/Swiss-Prot
    Q08257
    Conserved Domains (2) summary
    cd08253
    Location:8329
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
    COG0604
    Location:8327
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
  2. XM_017000367.2XP_016855856.1  quinone oxidoreductase isoform X2

    UniProtKB/Swiss-Prot
    Q08257
    Conserved Domains (2) summary
    cd08253
    Location:8295
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
    COG0604
    Location:8293
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
  3. XM_017000368.1XP_016855857.1  quinone oxidoreductase isoform X3

    UniProtKB/Swiss-Prot
    Q08257
    Conserved Domains (2) summary
    cd08253
    Location:3192
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
    COG0604
    Location:9190
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
  4. XM_005270491.4XP_005270548.1  quinone oxidoreductase isoform X3

    See identical proteins and their annotated locations for XP_005270548.1

    UniProtKB/Swiss-Prot
    Q08257
    Conserved Domains (2) summary
    cd08253
    Location:3192
    zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)
    COG0604
    Location:9190
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]
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