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Fosl2 fos-like antigen 2 [ Mus musculus (house mouse) ]

Gene ID: 14284, updated on 19-Feb-2023

Summary

Official Symbol
Fosl2provided by MGI
Official Full Name
fos-like antigen 2provided by MGI
Primary source
MGI:MGI:102858
See related
Ensembl:ENSMUSG00000029135 AllianceGenome:MGI:102858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fra-2
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within keratinocyte development; positive regulation of fibroblast proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; skeleton; skin; and telencephalon. Used to study idiopathic pulmonary fibrosis and systemic scleroderma. Orthologous to human FOSL2 (FOS like 2, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 84.0), ovary adult (RPKM 51.4) and 11 other tissues See more
Orthologs
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Genomic context

See Fosl2 in Genome Data Viewer
Location:
5 B1; 5 17.33 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (32292599..32315184)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (32136472..32157840)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40277 Neighboring gene microRNA 12198 Neighboring gene predicted gene, 36665 Neighboring gene predicted gene, 26335 Neighboring gene predicted gene, 36732

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008037.4NP_032063.2  fos-related antigen 2

    See identical proteins and their annotated locations for NP_032063.2

    Status: VALIDATED

    Source sequence(s)
    BC065131, BY785312
    Consensus CDS
    CCDS19190.1
    UniProtKB/Swiss-Prot
    P47930, Q8C231
    Related
    ENSMUSP00000031017.10, ENSMUST00000031017.11
    Conserved Domains (1) summary
    cd14721
    Location:134187
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    32292599..32315184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164789.1XP_036020682.1  fos-related antigen 2 isoform X1

    Conserved Domains (1) summary
    cl21462
    Location:127151
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain