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FOSL2 FOS like 2, AP-1 transcription factor subunit [ Homo sapiens (human) ]

Gene ID: 2355, updated on 1-Jun-2020

Summary

Official Symbol
FOSL2provided by HGNC
Official Full Name
FOS like 2, AP-1 transcription factor subunitprovided by HGNC
Primary source
HGNC:HGNC:3798
See related
Ensembl:ENSG00000075426 MIM:601575
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRA2
Summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in adrenal (RPKM 58.8), bone marrow (RPKM 50.0) and 23 other tissues See more
Orthologs

Genomic context

See FOSL2 in Genome Data Viewer
Location:
2p23.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (28392855..28417317)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (28615704..28637516)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374382 Neighboring gene uncharacterized LOC105374383 Neighboring gene uncharacterized protein FLJ31356 Neighboring gene uncharacterized LOC102723530 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23306

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell death TAS
Traceable Author Statement
more info
PubMed 
keratinocyte development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fos-related antigen 2
Names
FOS like 2, AP-1 trancription factor subunit
FOS like antigen 2
FRA-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005253.4NP_005244.1  fos-related antigen 2

    See identical proteins and their annotated locations for NP_005244.1

    Status: REVIEWED

    Source sequence(s)
    AC104695, AK026959, AK055579, BC022791, BM023443, BX647822
    Consensus CDS
    CCDS1766.1
    UniProtKB/Swiss-Prot
    P15408
    UniProtKB/TrEMBL
    Q9H5M2
    Related
    ENSP00000264716.4, ENST00000264716.9
    Conserved Domains (1) summary
    cd14721
    Location:134187
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    28392855..28417317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711976.3XP_006712039.1  fos-related antigen 2 isoform X1

    See identical proteins and their annotated locations for XP_006712039.1

    Conserved Domains (1) summary
    cd14721
    Location:134204
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
  2. XM_005264231.4XP_005264288.1  fos-related antigen 2 isoform X3

    Conserved Domains (1) summary
    cl21462
    Location:134158
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  3. XM_006711977.3XP_006712040.1  fos-related antigen 2 isoform X2

    See identical proteins and their annotated locations for XP_006712040.1

    Related
    ENSP00000368939.1, ENST00000379619.5
    Conserved Domains (1) summary
    cd14721
    Location:95165
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
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