FOSL2 FOS like 2, AP-1 transcription factor subunit [Homo sapiens (human)] - Gene

Summary

Official Symbol: FOSL2provided by HGNC
Official Full Name: FOS like 2, AP-1 transcription factor subunitprovided by HGNC
Primary source: HGNC:HGNC:3798
See related: Ensembl:ENSG00000075426 MIM:601575; AllianceGenome:HGNC:3798
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ACED; FRA2
Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
Expression: Ubiquitous expression in adrenal (RPKM 58.8), bone marrow (RPKM 50.0) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p23.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (28392858..28417317)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (28436151..28460588)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (28615725..28640184)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOSL2-mediated transcription of ISG20 induces M2 polarization of macrophages and enhances tumorigenic ability of glioblastoma cells.
Title: FOSL2-mediated transcription of ISG20 induces M2 polarization of macrophages and enhances tumorigenic ability of glioblastoma cells.
Role of Fra-2 in cancer.
Title: Role of Fra-2 in cancer.
Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28.
Title: Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28.
Circ_0005615 Regulates the Progression of Colorectal Cancer Through the miR-873-5p/FOSL2 Signaling Pathway.
Title: Circ_0005615 Regulates the Progression of Colorectal Cancer Through the miR-873-5p/FOSL2 Signaling Pathway.
LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis.
Title: LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis.
Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors.
Title: Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors.
FOSL2 truncating variants in the last exon cause a neurodevelopmental disorder with scalp and enamel defects.
Title: FOSL2 truncating variants in the last exon cause a neurodevelopmental disorder with scalp and enamel defects.
Upregulation of microRNA-597 in myelodysplastic syndromes induces apoptosis through FOSL2 inhibition.
Title: Upregulation of microRNA-597 in myelodysplastic syndromes induces apoptosis through FOSL2 inhibition.
Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression.
Title: Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression.
A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation.
Title: A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Aplasia cutis-enamel dysplasia syndrome MedGen: C5935608 OMIM: 620789 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2024-12-10) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2024-12-10) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2S366 (e-PCR)
- UniSTS:65856

STS-AA019641 (e-PCR)
- UniSTS:47010

RH17490 (e-PCR)
- UniSTS:30140

MARC_23763-23764:1027442861:1 (e-PCR)
- UniSTS:268769

FOSL2_8355 (e-PCR)
- UniSTS:467695

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within B cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within NK T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within alveolar secondary septum development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone mineralization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cell death	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondrocyte proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collagen biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collagen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fat cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fat pad development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within growth plate cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homeostasis of number of cells	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within keratinocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung connective tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within macrophage differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mucus secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myofibroblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of myofibroblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bleomycin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to glucocorticoid	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hypoxia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to interleukin-13	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to interleukin-7	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smooth muscle tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of transcription factor AP-1 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fos-related antigen 2

Names: FOS like 2, AP-1 trancription factor subunit; FOS like antigen 2; FRA-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005253.4 → NP_005244.1 fos-related antigen 2

See identical proteins and their annotated locations for NP_005244.1

Status: REVIEWED

Source sequence(s)

AC104695, AK026959, AK055579, BC022791, BM023443, BX647822

Consensus CDS

CCDS1766.1

UniProtKB/Swiss-Prot

B2RD58, B3KP27, B4DYV4, P15408, Q6FG46

Related

ENSP00000264716.4, ENST00000264716.9

Conserved Domains (1) summary

cd14721
Location:134 → 187

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

28392858..28417317

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005264231.5 → XP_005264288.1 fos-related antigen 2 isoform X3

Conserved Domains (1) summary

cl21462
Location:134 → 158

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
XM_006711976.4 → XP_006712039.1 fos-related antigen 2 isoform X1

See identical proteins and their annotated locations for XP_006712039.1

Related

ENSP00000572852.1, ENST00000902793.1

Conserved Domains (1) summary

cd14721
Location:134 → 204

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
XM_006711977.4 → XP_006712040.1 fos-related antigen 2 isoform X2

See identical proteins and their annotated locations for XP_006712040.1

Related

ENSP00000368939.1, ENST00000379619.5

Conserved Domains (1) summary

cd14721
Location:95 → 165

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain