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FOSL2 FOS like 2, AP-1 transcription factor subunit [ Homo sapiens (human) ]

Gene ID: 2355, updated on 23-Nov-2023

Summary

Official Symbol
FOSL2provided by HGNC
Official Full Name
FOS like 2, AP-1 transcription factor subunitprovided by HGNC
Primary source
HGNC:HGNC:3798
See related
Ensembl:ENSG00000075426 MIM:601575; AllianceGenome:HGNC:3798
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRA2
Summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in adrenal (RPKM 58.8), bone marrow (RPKM 50.0) and 23 other tissues See more
Orthologs
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Genomic context

See FOSL2 in Genome Data Viewer
Location:
2p23.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (28392858..28417317)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (28436151..28460588)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (28615725..28640184)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374382 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:28582187-28583386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:28583785-28584472 Neighboring gene uncharacterized LOC105374383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:28602778-28603278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:28603279-28603779 Neighboring gene FOSL2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11307 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:28615755-28616686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:28616842-28617342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:28617343-28617843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:28635908-28636512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:28636513-28637117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:28662749-28663248 Neighboring gene uncharacterized LOC102723530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:28674597-28675110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:28675111-28675624 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ23306

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in NK T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in alveolar secondary septum development IEA
Inferred from Electronic Annotation
more info
 
involved_in bone mineralization IEA
Inferred from Electronic Annotation
more info
 
involved_in cell death TAS
Traceable Author Statement
more info
PubMed 
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chondrocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fat cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in fat pad development IEA
Inferred from Electronic Annotation
more info
 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in growth plate cartilage development IEA
Inferred from Electronic Annotation
more info
 
involved_in homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in keratinocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in lung connective tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in mucus secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in myofibroblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in neutrophil differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of myofibroblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in response to bleomycin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to interleukin-13 IEA
Inferred from Electronic Annotation
more info
 
involved_in response to interleukin-7 IEA
Inferred from Electronic Annotation
more info
 
involved_in response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in smooth muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in tissue remodeling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
fos-related antigen 2
Names
FOS like 2, AP-1 trancription factor subunit
FOS like antigen 2
FRA-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005253.4NP_005244.1  fos-related antigen 2

    See identical proteins and their annotated locations for NP_005244.1

    Status: REVIEWED

    Source sequence(s)
    AC104695, AK026959, AK055579, BC022791, BM023443, BX647822
    Consensus CDS
    CCDS1766.1
    UniProtKB/Swiss-Prot
    B2RD58, B3KP27, B4DYV4, P15408, Q6FG46
    Related
    ENSP00000264716.4, ENST00000264716.9
    Conserved Domains (1) summary
    cd14721
    Location:134187
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    28392858..28417317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264231.5XP_005264288.1  fos-related antigen 2 isoform X3

    Conserved Domains (1) summary
    cl21462
    Location:134158
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  2. XM_006711976.4XP_006712039.1  fos-related antigen 2 isoform X1

    See identical proteins and their annotated locations for XP_006712039.1

    Conserved Domains (1) summary
    cd14721
    Location:134204
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
  3. XM_006711977.4XP_006712040.1  fos-related antigen 2 isoform X2

    See identical proteins and their annotated locations for XP_006712040.1

    Related
    ENSP00000368939.1, ENST00000379619.5
    Conserved Domains (1) summary
    cd14721
    Location:95165
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    28436151..28460588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341223.1XP_054197198.1  fos-related antigen 2 isoform X3

  2. XM_054341221.1XP_054197196.1  fos-related antigen 2 isoform X1

  3. XM_054341222.1XP_054197197.1  fos-related antigen 2 isoform X2