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RAB40A RAB40A, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 142684, updated on 5-Aug-2022

Summary

Official Symbol
RAB40Aprovided by HGNC
Official Full Name
RAB40A, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:18283
See related
Ensembl:ENSG00000172476 MIM:301065; AllianceGenome:HGNC:18283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAR2; RAR2A
Summary
This gene encodes a member of the Rab40 subfamily of Rab small GTP-binding proteins that contains a C-terminal suppressors of cytokine signaling box. [provided by RefSeq, Apr 2010]
Expression
Broad expression in esophagus (RPKM 1.8), testis (RPKM 1.2) and 15 other tissues See more
Orthologs
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Genomic context

See RAB40A in Genome Data Viewer
Location:
Xq22.2
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103493266..103519489, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101946141..101966502, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102754058..102774417, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905204 Neighboring gene transcription elongation factor A like 9 Neighboring gene uncharacterized LL0XNC01-250H12.3 Neighboring gene brain expressed X-linked 3 Neighboring gene long intergenic non-protein coding RNA 2589 Neighboring gene transcription elongation factor A like 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies RAB40A, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142061

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-40A
Names
SOCS box-containing protein RAR2A
protein Rar-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017149.1 RefSeqGene

    Range
    5001..25360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080879.3NP_543155.2  ras-related protein Rab-40A

    See identical proteins and their annotated locations for NP_543155.2

    Status: REVIEWED

    Source sequence(s)
    AF132748, AF422143, H24206, Z69733
    Consensus CDS
    CCDS35357.1
    UniProtKB/Swiss-Prot
    Q8TF06, Q8WXH6
    Related
    ENSP00000305648.1, ENST00000304236.2
    Conserved Domains (2) summary
    cd03742
    Location:187228
    SOCS_Rab40; SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as ...
    cl21455
    Location:9277
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    103493266..103519489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441843.1XP_047297799.1  ras-related protein Rab-40A isoform X1

    UniProtKB/Swiss-Prot
    Q8TF06
  2. XM_047441844.1XP_047297800.1  ras-related protein Rab-40A isoform X1

    UniProtKB/Swiss-Prot
    Q8TF06
    Related
    ENSP00000361716.1, ENST00000372633.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    101946141..101966502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)