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Fmo3 flavin containing monooxygenase 3 [ Mus musculus (house mouse) ]

Gene ID: 14262, updated on 18-Apr-2024

Summary

Official Symbol
Fmo3provided by MGI
Official Full Name
flavin containing monooxygenase 3provided by MGI
Primary source
MGI:MGI:1100496
See related
Ensembl:ENSMUSG00000026691 AllianceGenome:MGI:1100496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable N,N-dimethylaniline monooxygenase activity; NADP binding activity; and amino acid binding activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to human FMO3 (flavin containing dimethylaniline monoxygenase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 25.6) and lung adult (RPKM 4.5) See more
Orthologs
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Genomic context

Location:
1 H2.1; 1 70.34 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162781368..162812097, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162953799..162984528, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene flavin containing monooxygenase 2 Neighboring gene flavin containing monooxygenase 6 Neighboring gene predicted gene, 32279 Neighboring gene STARR-seq mESC enhancer starr_02847 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene maestro heat-like repeat family member 9 Neighboring gene predicted gene, 22671

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables N,N-dimethylaniline monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables NADP binding ISO
Inferred from Sequence Orthology
more info
 
enables albendazole monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables hypotaurine dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables trimethylamine monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in taurine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
flavin-containing monooxygenase 3
Names
dimethylaniline monooxygenase [N-oxide-forming] 3
dimethylaniline oxidase 3
hepatic flavin-containing monooxygenase 3
trimethylamine monooxygenase
NP_032056.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008030.2NP_032056.1  flavin-containing monooxygenase 3

    See identical proteins and their annotated locations for NP_032056.1

    Status: VALIDATED

    Source sequence(s)
    AK050123, AK149440, D18023
    Consensus CDS
    CCDS15426.1
    UniProtKB/Swiss-Prot
    P97501
    UniProtKB/TrEMBL
    Q3UEN4
    Related
    ENSMUSP00000028010.8, ENSMUST00000028010.9
    Conserved Domains (2) summary
    pfam00743
    Location:2533
    FMO-like; Flavin-binding monooxygenase-like
    cl21454
    Location:6220
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    162781368..162812097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)