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Flot2 flotillin 2 [ Mus musculus (house mouse) ]

Gene ID: 14252, updated on 10-Oct-2019

Summary

Official Symbol
Flot2provided by MGI
Official Full Name
flotillin 2provided by MGI
Primary source
MGI:MGI:103309
See related
Ensembl:ENSMUSG00000061981
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Esa; AI573412; reggie-2
Expression
Ubiquitous expression in adrenal adult (RPKM 67.2), mammary gland adult (RPKM 55.9) and 28 other tissues See more
Orthologs

Genomic context

See Flot2 in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
14
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78037931..78060434)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (77851443..77873934)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene PHD finger protein 12 Neighboring gene uncharacterized LOC115487790 Neighboring gene dehydrogenase/reductase (SDR family) member 13, opposite strand Neighboring gene dehydrogenase/reductase (SDR family) member 13 Neighboring gene microRNA 451a Neighboring gene microRNA 451b Neighboring gene microRNA 144

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
acrosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
anchored component of presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
caveola ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
flotillin complex IDA
Inferred from Direct Assay
more info
PubMed 
flotillin complex ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 
uropod ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
flotillin-2
Names
epidermal surface antigen
membrane component chromosome 17 surface marker 1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040403.2NP_001035493.1  flotillin-2 isoform 1

    See identical proteins and their annotated locations for NP_001035493.1

    Status: VALIDATED

    Source sequence(s)
    AL669840, BC070423, BY204171, CD774654
    Consensus CDS
    CCDS36237.1
    UniProtKB/Swiss-Prot
    Q60634
    Related
    ENSMUSP00000072136.5, ENSMUST00000072289.11
    Conserved Domains (2) summary
    COG2268
    Location:6417
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:34178
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
  2. NM_001284227.2NP_001271156.1  flotillin-2 isoform 3

    See identical proteins and their annotated locations for NP_001271156.1

    Status: VALIDATED

    Source sequence(s)
    AK149530, AL669840, BC070423, BY195482, CD774654
    UniProtKB/Swiss-Prot
    Q60634
    UniProtKB/TrEMBL
    Q3UEG9
    Conserved Domains (3) summary
    smart00244
    Location:115297
    PHB; prohibitin homologues
    cd03399
    Location:72206
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam15975
    Location:341415
    Flot; Flotillin
  3. NM_001284228.3NP_001271157.1  flotillin-2 isoform 2

    See identical proteins and their annotated locations for NP_001271157.1

    Status: VALIDATED

    Source sequence(s)
    AL669840, BC070423, CD774654, U07890
    Consensus CDS
    CCDS25088.1
    UniProtKB/Swiss-Prot
    Q60634
    Conserved Domains (2) summary
    cd03399
    Location:1129
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:1368
    Flot; Flotillin
  4. NM_001362625.1NP_001349554.1  flotillin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL669840, CD774654
    Related
    ENSMUSP00000073342.6, ENSMUST00000073660.6
    Conserved Domains (2) summary
    COG2268
    Location:6417
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:34178
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
  5. NM_001362626.1NP_001349555.1  flotillin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669840, CD774654
    Conserved Domains (2) summary
    cd03399
    Location:1129
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:1368
    Flot; Flotillin
  6. NM_001362627.1NP_001349556.1  flotillin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669840, CD774654
    Conserved Domains (2) summary
    cd03399
    Location:1101
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:8340
    Flot; Flotillin
  7. NM_008028.4NP_032054.1  flotillin-2 isoform 2

    See identical proteins and their annotated locations for NP_032054.1

    Status: VALIDATED

    Source sequence(s)
    AK149530, AL669840, BC070423, BY195482, CD774654
    Consensus CDS
    CCDS25088.1
    UniProtKB/Swiss-Prot
    Q60634
    Related
    ENSMUSP00000098347.2, ENSMUST00000100784.8
    Conserved Domains (2) summary
    cd03399
    Location:1129
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:1368
    Flot; Flotillin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    78037931..78060434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245557.1XP_030101417.1  flotillin-2 isoform X1

  2. XM_030245558.1XP_030101418.1  flotillin-2 isoform X2

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