Format

Send to:

Choose Destination

FLOT2 flotillin 2 [ Homo sapiens (human) ]

Gene ID: 2319, updated on 4-Nov-2018

Summary

Official Symbol
FLOT2provided by HGNC
Official Full Name
flotillin 2provided by HGNC
Primary source
HGNC:HGNC:3758
See related
Ensembl:ENSG00000132589 MIM:131560; Vega:OTTHUMG00000132674
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESA; ECS1; ESA1; ECS-1; M17S1
Summary
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 42.8), spleen (RPKM 42.2) and 25 other tissues See more
Orthologs

Genomic context

See FLOT2 in Genome Data Viewer
Location:
17q11.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (28879335..28897736, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27206356..27224715, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene microRNA 4732 Neighboring gene microRNA 144 Neighboring gene dehydrogenase/reductase 13 Neighboring gene PHD finger protein 12 Neighboring gene uncharacterized LOC101927018

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
    Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
    Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...
  • SALM protein interactions at the synapses, organism-specific biosystem (from REACTOME)
    SALM protein interactions at the synapses, organism-specific biosystemRecruitment of receptors and ion channels to the postsynaptic membrane is the last step in synapse formation. Many of these proteins interact directly or indirectly with postsynaptic density-95 (PSD9...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 
protease binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
anchored component of presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
NOT apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell contact zone IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
flotillin complex IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
uropod IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
flotillin-2
Names
Flotillin 2 (epidermal surface antigen 1)
epidermal surface antigen
membrane component chromosome 17 surface marker 1
membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330170.1NP_001317099.1  flotillin-2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC024267, BQ019299
    Consensus CDS
    CCDS82097.1
    UniProtKB/TrEMBL
    J3QLD9
    Related
    ENSP00000463503.1, ENST00000585169.5
    Conserved Domains (2) summary
    cd03399
    Location:34178
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:6417
    Flot; Flotillin
  2. NM_004475.2NP_004466.2  flotillin-2 isoform 1

    See identical proteins and their annotated locations for NP_004466.2

    Status: REVIEWED

    Source sequence(s)
    BC003683, BC017292, CA390100, M60922
    Consensus CDS
    CCDS11245.2
    UniProtKB/Swiss-Prot
    Q14254
    UniProtKB/TrEMBL
    A0A024QZ62, Q9BTI6
    Related
    ENSP00000378368.3, OTTHUMP00000163514, ENST00000394908.8, OTTHUMT00000255935
    Conserved Domains (2) summary
    cd03399
    Location:34178
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:6417
    Flot; Flotillin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    28879335..28897736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257953.2XP_005258010.1  flotillin-2 isoform X4

    See identical proteins and their annotated locations for XP_005258010.1

    Conserved Domains (2) summary
    cd03399
    Location:1101
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:8340
    Flot; Flotillin
  2. XM_017024395.1XP_016879884.1  flotillin-2 isoform X2

    UniProtKB/Swiss-Prot
    Q14254
    UniProtKB/TrEMBL
    Q6FG43
    Conserved Domains (2) summary
    cd03399
    Location:1129
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:1368
    Flot; Flotillin
  3. XM_024450666.1XP_024306434.1  flotillin-2 isoform X1

    Conserved Domains (2) summary
    cd03399
    Location:34178
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:6450
    Flot; Flotillin
  4. XM_017024396.1XP_016879885.1  flotillin-2 isoform X3

  5. XM_024450667.1XP_024306435.1  flotillin-2 isoform X4

    Conserved Domains (2) summary
    cd03399
    Location:1101
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:8340
    Flot; Flotillin
  6. XM_017024394.1XP_016879883.1  flotillin-2 isoform X2

    UniProtKB/Swiss-Prot
    Q14254
    UniProtKB/TrEMBL
    Q6FG43
    Conserved Domains (2) summary
    cd03399
    Location:1129
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:1368
    Flot; Flotillin
Support Center