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Foxf2 forkhead box F2 [ Mus musculus (house mouse) ]

Gene ID: 14238, updated on 12-May-2024

Summary

Official Symbol
Foxf2provided by MGI
Official Full Name
forkhead box F2provided by MGI
Primary source
MGI:MGI:1347479
See related
Ensembl:ENSMUSG00000038402 AllianceGenome:MGI:1347479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LUN; Fkh20; FREAC2
Summary
Enables DNA binding activity and DNA-binding transcription factor activity. Involved in embryonic camera-type eye morphogenesis. Acts upstream of or within several processes, including embryonic digestive tract development; establishment of planar polarity of embryonic epithelium; and negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including alimentary system; ear; embryo mesenchyme; genitourinary system; and limb digit. Orthologous to human FOXF2 (forkhead box F2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 29.7), stomach adult (RPKM 20.5) and 12 other tissues See more
Orthologs
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Genomic context

See Foxf2 in Genome Data Viewer
Location:
13 A3.2; 13 13.48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (31809686..31815390)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (31625816..31631406)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700018A04 gene Neighboring gene predicted gene 11377 Neighboring gene uncharacterized LOC118568038 Neighboring gene STARR-seq mESC enhancer starr_34082 Neighboring gene STARR-seq mESC enhancer starr_34086 Neighboring gene predicted gene, 25186 Neighboring gene predicted gene, 57597

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in embryonic camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digestive tract development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within establishment of planar polarity of embryonic epithelium IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within establishment of planar polarity of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in genitalia development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in roof of mouth development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
forkhead box protein F2
Names
forkhead homolog 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010225.3NP_034355.2  forkhead box protein F2

    See identical proteins and their annotated locations for NP_034355.2

    Status: VALIDATED

    Source sequence(s)
    AL590625
    Consensus CDS
    CCDS26424.1
    UniProtKB/Swiss-Prot
    B2RQI5, O54743, Q3V1L3, Q78DW1
    Related
    ENSMUSP00000046789.3, ENSMUST00000042054.3
    Conserved Domains (1) summary
    smart00339
    Location:100188
    FH; FORKHEAD

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    31809686..31815390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)