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FOXF2 forkhead box F2 [ Homo sapiens (human) ]

Gene ID: 2295, updated on 17-May-2020

Summary

Official Symbol
FOXF2provided by HGNC
Official Full Name
forkhead box F2provided by HGNC
Primary source
HGNC:HGNC:3810
See related
Ensembl:ENSG00000137273 MIM:603250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKHL6; FREAC2; FREAC-2
Summary
FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lung (RPKM 8.4), prostate (RPKM 6.0) and 13 other tissues See more
Orthologs

Genomic context

See FOXF2 in Genome Data Viewer
Location:
6p25.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (1389576..1395603)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (1390069..1395832)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1394 Neighboring gene uncharacterized LOC112267978 Neighboring gene uncharacterized LOC105374880 Neighboring gene microRNA 6720 Neighboring gene uncharacterized LOC102723944 Neighboring gene uncharacterized LOC105374883 Neighboring gene RNA, 7SL, cytoplasmic 352, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
forkhead box protein F2
Names
forkhead-like 6
forkhead-related activator 2
forkhead-related protein FKHL6
forkhead-related transcription factor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046984.1 RefSeqGene

    Range
    4743..10770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1190

mRNA and Protein(s)

  1. NM_001452.2NP_001443.1  forkhead box protein F2

    See identical proteins and their annotated locations for NP_001443.1

    Status: REVIEWED

    Source sequence(s)
    AL034346, CA448136, U13220
    Consensus CDS
    CCDS4472.1
    UniProtKB/Swiss-Prot
    Q12947
    Related
    ENSP00000496415.1, ENST00000645481.2
    Conserved Domains (1) summary
    smart00339
    Location:100188
    FH; FORKHEAD

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    1389576..1395603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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