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Smc2 structural maintenance of chromosomes 2 [ Mus musculus (house mouse) ]

Gene ID: 14211, updated on 8-Dec-2022

Summary

Official Symbol
Smc2provided by MGI
Official Full Name
structural maintenance of chromosomes 2provided by MGI
Primary source
MGI:MGI:106067
See related
Ensembl:ENSMUSG00000028312 AllianceGenome:MGI:106067
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAPE; CAP-E; Fin16; SMC-2; Smc2l1; 5730502P04Rik
Summary
The protein encoded by this gene is a component of both condensin I and condensin II complexes, and forms a heterodimer with structural maintenance of chromosome 4 (Smc4). This heterodimer is the catalytic subunit for both condensin complexes, and is involved in several processes, including chromosome condensation during mitosis and meiosis, cohesin removal during mitosis and meiosis, and single-strand break (SSB) repair. Reduced expression of this gene results in chromosome segregation defects during mitosis and meiosis, with a more severe defect observed in embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression
Biased expression in liver E14 (RPKM 13.6), CNS E11.5 (RPKM 12.6) and 13 other tissues See more
Orthologs
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Genomic context

See Smc2 in Genome Data Viewer
Location:
4 B2; 4 28.31 cM
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (52438966..52488365)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (52439221..52488365)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene polymerase (DNA-directed), delta 3, accessory subunit pseudogene Neighboring gene structural maintenance of chromosomes 2, opposite strand Neighboring gene Tmc4 retrotransposed pseudogene Neighboring gene VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), pseudogene Neighboring gene topoisomerase I binding, arginine/serine-rich like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in condensed chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of condensin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of condensin complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of condensin complex ISO
Inferred from Sequence Orthology
more info
 
part_of condensin complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of condensin complex TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
structural maintenance of chromosomes protein 2
Names
FGF-inducible protein 16
SMC protein 2
SMC2 structural maintenance of chromosomes 2-like 1
XCAP-E homolog
chromosome-associated protein E
fibroblast growth factor inducible 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301412.1NP_001288341.1  structural maintenance of chromosomes protein 2

    See identical proteins and their annotated locations for NP_001288341.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK145341, BC094380, CJ049961
    Consensus CDS
    CCDS18180.1
    UniProtKB/Swiss-Prot
    Q8CG48, Q9CSD8
    UniProtKB/TrEMBL
    Q3ULS2
    Related
    ENSMUSP00000099979.4, ENSMUST00000102915.10
    Conserved Domains (1) summary
    COG1196
    Location:11168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  2. NM_008017.4NP_032043.3  structural maintenance of chromosomes protein 2

    See identical proteins and their annotated locations for NP_032043.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK145341, BC094380, CJ049961
    Consensus CDS
    CCDS18180.1
    UniProtKB/Swiss-Prot
    Q8CG48, Q9CSD8
    UniProtKB/TrEMBL
    Q3ULS2
    Related
    ENSMUSP00000113940.2, ENSMUST00000117280.8
    Conserved Domains (1) summary
    COG1196
    Location:11168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    52438966..52488365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163679.1XP_036019572.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9CSD8
    Conserved Domains (1) summary
    COG1196
    Location:11168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]