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SMC2 structural maintenance of chromosomes 2 [ Homo sapiens (human) ]

Gene ID: 10592, updated on 17-Jun-2019

Summary

Official Symbol
SMC2provided by HGNC
Official Full Name
structural maintenance of chromosomes 2provided by HGNC
Primary source
HGNC:HGNC:14011
See related
Ensembl:ENSG00000136824 MIM:605576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAPE; CAP-E; SMC-2; SMC2L1
Expression
Ubiquitous expression in lymph node (RPKM 6.5), testis (RPKM 6.0) and 24 other tissues See more
Orthologs

Genomic context

See SMC2 in Genome Data Viewer
Location:
9q31.1
Exon count:
29
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (104093760..104141419)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (106856213..106903700)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928523 Neighboring gene SMC2 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105376194 Neighboring gene topoisomerase I binding, arginine and serine rich like, pseudogene Neighboring gene WDR45-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
NHGRI GWA Catalog
Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with SMC2 in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora B signaling, organism-specific biosystem
    Aurora B signaling
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Condensation of Prometaphase Chromosomes, organism-specific biosystem (from REACTOME)
    Condensation of Prometaphase Chromosomes, organism-specific biosystemThe condensin I complex is evolutionarily conserved and consists of five subunits: two SMC (structural maintenance of chromosomes) family subunits, SMC2 and SMC4, and three non-SMC subunits, NCAPD2, ...
  • Condensation of Prophase Chromosomes, organism-specific biosystem (from REACTOME)
    Condensation of Prophase Chromosomes, organism-specific biosystemIn mitotic prophase, the action of the condensin II complex enables initial chromosome condensation.The condensin II complex subunit NCAPD3 binds monomethylated histone H4 (H4K20me1), thereby associa...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Mitotic Prophase, organism-specific biosystem (from REACTOME)
    Mitotic Prophase, organism-specific biosystemDuring prophase, the chromatin in the nucleus condenses, and the nucleolus disappears. Centrioles begin moving to the opposite poles or sides of the cell. Some of the fibers that extend from the cen...
  • Retinoblastoma (RB) in Cancer, organism-specific biosystem (from WikiPathways)
    Retinoblastoma (RB) in Cancer, organism-specific biosystemDescribes the role of retinoblastoma (RB) gene in cancer.

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
kinetochore organization IEA
Inferred from Electronic Annotation
more info
 
meiotic chromosome condensation IEA
Inferred from Electronic Annotation
more info
 
meiotic chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
mitotic chromosome condensation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
condensin complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
structural maintenance of chromosomes protein 2
Names
SMC protein 2
SMC2 (structural maintenance of chromosomes 2, yeast)-like 1
XCAP-E homolog
chromosome-associated protein E
structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042550.2NP_001036015.1  structural maintenance of chromosomes protein 2

    See identical proteins and their annotated locations for NP_001036015.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AK001485, AK124957, AL354938, AL833191, BC032705, BF969462
    Consensus CDS
    CCDS35086.1
    UniProtKB/Swiss-Prot
    O95347
    UniProtKB/TrEMBL
    A0A024R158, B3KMB1, Q05BV1, Q6IPS5
    Related
    ENSP00000363919.3, ENST00000374787.7
    Conserved Domains (8) summary
    pfam06673
    Location:252465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10741168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001042551.2NP_001036016.1  structural maintenance of chromosomes protein 2

    See identical proteins and their annotated locations for NP_001036016.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL354938, AL833191, BC032705, BF969462
    Consensus CDS
    CCDS35086.1
    UniProtKB/Swiss-Prot
    O95347
    UniProtKB/TrEMBL
    A0A024R158, Q05BV1
    Conserved Domains (8) summary
    pfam06673
    Location:252465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10741168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_001265602.1NP_001252531.1  structural maintenance of chromosomes protein 2

    See identical proteins and their annotated locations for NP_001252531.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK292599, AL833191, BC144163, BF969462, BN000163
    Consensus CDS
    CCDS35086.1
    UniProtKB/Swiss-Prot
    O95347
    UniProtKB/TrEMBL
    A0A024R158, A8K984, B7ZLZ7
    Related
    ENSP00000286398.7, ENST00000286398.11
    Conserved Domains (8) summary
    pfam06673
    Location:252465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10741168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_006444.3NP_006435.2  structural maintenance of chromosomes protein 2

    See identical proteins and their annotated locations for NP_006435.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AF092563, AK124957, AL354938, AL833191, BC017845, BC032705, BC055081, BF969462
    Consensus CDS
    CCDS35086.1
    UniProtKB/Swiss-Prot
    O95347
    UniProtKB/TrEMBL
    A0A024R158, Q05BV1, Q05D74, Q7Z2X1
    Related
    ENSP00000363925.3, ENST00000374793.8
    Conserved Domains (8) summary
    pfam06673
    Location:252465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10741168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    104093760..104141419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518149.3XP_011516451.1  structural maintenance of chromosomes protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011516451.1

    UniProtKB/Swiss-Prot
    O95347
    UniProtKB/TrEMBL
    A0A024R158
    Conserved Domains (8) summary
    pfam06673
    Location:252465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10741168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_017014211.2XP_016869700.1  structural maintenance of chromosomes protein 2 isoform X2

    Conserved Domains (6) summary
    pfam06673
    Location:202415
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    smart00968
    Location:472589
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11118
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:690791
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:586727
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10241118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_006716933.3XP_006716996.1  structural maintenance of chromosomes protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006716996.1

    UniProtKB/Swiss-Prot
    O95347
    UniProtKB/TrEMBL
    A0A024R158
    Conserved Domains (8) summary
    pfam06673
    Location:252465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10741168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_011518152.2XP_011516454.1  structural maintenance of chromosomes protein 2 isoform X3

    Conserved Domains (7) summary
    pfam06673
    Location:252465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11090
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740841
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:636777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10741090
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_011518153.1XP_011516455.1  structural maintenance of chromosomes protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011516455.1

    UniProtKB/Swiss-Prot
    O95347
    Conserved Domains (7) summary
    pfam06673
    Location:252465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11090
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740841
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:636777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10741090
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_024447383.1XP_024303151.1  structural maintenance of chromosomes protein 2 isoform X5

    Conserved Domains (1) summary
    COG1196
    Location:1713
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  7. XM_011518151.2XP_011516453.1  structural maintenance of chromosomes protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011516453.1

    Conserved Domains (6) summary
    pfam06673
    Location:202415
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    smart00968
    Location:472589
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11118
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:690791
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:586727
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10241118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  8. XM_011518150.2XP_011516452.1  structural maintenance of chromosomes protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011516452.1

    Conserved Domains (6) summary
    pfam06673
    Location:202415
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    smart00968
    Location:472589
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11118
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:690791
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:586727
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10241118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. XM_017014210.2XP_016869699.1  structural maintenance of chromosomes protein 2 isoform X2

    Conserved Domains (6) summary
    pfam06673
    Location:202415
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    smart00968
    Location:472589
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11118
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:690791
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:586727
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10241118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  10. XM_017014207.1XP_016869696.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O95347
    UniProtKB/TrEMBL
    A0A024R158
    Conserved Domains (8) summary
    pfam06673
    Location:252465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10741168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  11. XM_017014209.1XP_016869698.1  structural maintenance of chromosomes protein 2 isoform X2

    Conserved Domains (6) summary
    pfam06673
    Location:202415
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    smart00968
    Location:472589
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11118
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:690791
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:586727
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10241118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  12. XM_017014212.1XP_016869701.1  structural maintenance of chromosomes protein 2 isoform X2

    Conserved Domains (6) summary
    pfam06673
    Location:202415
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    smart00968
    Location:472589
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11118
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:690791
    DUF4200; Domain of unknown function (DUF4200)
    cl19219
    Location:586727
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10241118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  13. XM_017014206.1XP_016869695.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O95347
    UniProtKB/TrEMBL
    A0A024R158
    Conserved Domains (8) summary
    pfam06673
    Location:252465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10741168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  14. XM_017014208.1XP_016869697.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O95347
    UniProtKB/TrEMBL
    A0A024R158
    Conserved Domains (8) summary
    pfam06673
    Location:252465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10741168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  15. XM_011518148.2XP_011516450.1  structural maintenance of chromosomes protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011516450.1

    UniProtKB/Swiss-Prot
    O95347
    UniProtKB/TrEMBL
    A0A024R158
    Conserved Domains (8) summary
    pfam06673
    Location:252465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1172
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740841
    DUF4200; Domain of unknown function (DUF4200)
    pfam15456
    Location:193287
    Uds1; Up-regulated During Septation
    cl19219
    Location:636777
    DUF342; Protein of unknown function (DUF342)
    cl21455
    Location:10741168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_002956745.1 RNA Sequence

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