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Fem1a fem 1 homolog a [ Mus musculus (house mouse) ]

Gene ID: 14154, updated on 8-May-2024

Summary

Official Symbol
Fem1aprovided by MGI
Official Full Name
fem 1 homolog aprovided by MGI
Primary source
MGI:MGI:1335089
See related
Ensembl:ENSMUSG00000043683 AllianceGenome:MGI:1335089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eprap; Fem1aa
Summary
Predicted to enable EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of inflammatory response. Acts upstream of or within negative regulation of MAP kinase activity and negative regulation of inflammatory response. Located in mitochondrion. Is expressed in several structures, including blastocyst; central nervous system; genitourinary system; retina; and spleen. Orthologous to human FEM1A (fem-1 homolog A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Fem1a in Genome Data Viewer
Location:
17 D; 17 29.24 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56563793..56570608)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56256793..56263608)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A230051N06 gene Neighboring gene microRNA 7b Neighboring gene STARR-positive B cell enhancer ABC_E490 Neighboring gene STARR-positive B cell enhancer ABC_E613 Neighboring gene STARR-positive B cell enhancer ABC_E7548 Neighboring gene TIR domain containing adaptor molecule 1 Neighboring gene STARR-positive B cell enhancer ABC_E1945 Neighboring gene STARR-positive B cell enhancer ABC_E11798 Neighboring gene perilipin 3 Neighboring gene STARR-positive B cell enhancer ABC_E8686

Genomic regions, transcripts, and products

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117925

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables EP4 subtype prostaglandin E2 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein fem-1 homolog A-A
Names
FEM1-alpha-A
FEM1a-A
feminization 1 homolog a
prostaglandin E receptor 4-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010192.4NP_034322.3  protein fem-1 homolog A-A

    See identical proteins and their annotated locations for NP_034322.3

    Status: VALIDATED

    Source sequence(s)
    AI021455, AK042461, AK080978, BC054382, BP757418, BY343573, CO426831
    Consensus CDS
    CCDS28899.1
    UniProtKB/Swiss-Prot
    Q3U2C2, Q8C4V3, Q8C6D9, Q8CBW9, Q9DBC6, Q9Z2G1
    Related
    ENSMUSP00000057996.4, ENSMUST00000060253.5
    Conserved Domains (6) summary
    smart00248
    Location:4370
    ANK; ankyrin repeats
    cd00204
    Location:82203
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:87179
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:183235
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:552605
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:82113
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56563793..56570608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)