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FEM1A fem-1 homolog A [ Homo sapiens (human) ]

Gene ID: 55527, updated on 18-Sep-2024

Summary

Official Symbol
FEM1Aprovided by HGNC
Official Full Name
fem-1 homolog Aprovided by HGNC
Primary source
HGNC:HGNC:16934
See related
Ensembl:ENSG00000141965 MIM:613538; AllianceGenome:HGNC:16934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPRAP
Summary
Enables EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Involved in negative regulation of inflammatory response and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul2-RING ubiquitin ligase complex. Is active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See FEM1A in Genome Data Viewer
Location:
19p13.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4791734..4801273)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4777196..4786749)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4791746..4801285)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MIR7-3 host gene Neighboring gene microRNA 7-3 Neighboring gene MPRA-validated peak3287 silencer Neighboring gene uncharacterized LOC124904620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4791399-4792056 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4792057-4792713 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4792714-4793370 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:4804346-4804507 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:4812531-4813730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13783 Neighboring gene TIR domain containing adaptor molecule 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9906 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13785 Neighboring gene perilipin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4866939-4867439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9909

Genomic regions, transcripts, and products

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp762M136

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables EP4 subtype prostaglandin E2 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein fem-1 homolog A
Names
FEM1-alpha
prostaglandin E receptor 4-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018708.3NP_061178.1  protein fem-1 homolog A

    See identical proteins and their annotated locations for NP_061178.1

    Status: VALIDATED

    Source sequence(s)
    AC005523
    Consensus CDS
    CCDS12135.1
    UniProtKB/Swiss-Prot
    B2RDI3, Q711P8, Q9BSK4, Q9NPN7, Q9NPW8
    Related
    ENSP00000269856.3, ENST00000269856.5
    Conserved Domains (6) summary
    smart00248
    Location:4370
    ANK; ankyrin repeats
    cd00204
    Location:82203
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:87179
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:183235
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:567620
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:82113
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4791734..4801273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4777196..4786749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)