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Fasn fatty acid synthase [ Mus musculus (house mouse) ]

Gene ID: 14104, updated on 21-Jan-2020

Summary

Official Symbol
Fasnprovided by MGI
Official Full Name
fatty acid synthaseprovided by MGI
Primary source
MGI:MGI:95485
See related
Ensembl:ENSMUSG00000025153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FAS; A630082H08Rik
Expression
Biased expression in mammary gland adult (RPKM 1605.0), subcutaneous fat pad adult (RPKM 1125.4) and 6 other tissues See more
Orthologs

Genomic context

See Fasn in Genome Data Viewer
Location:
11 E2; 11 84.56 cM
Exon count:
44
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120805958..120825166, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (120667272..120685861, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1-like (S. cerevisiae) Neighboring gene coiled-coil domain containing 57 Neighboring gene RIKEN cDNA A430102A20 gene Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 3 Neighboring gene casein kinase 1, delta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-oxo-glutaryl-[acp] methyl ester reductase activity IEA
Inferred from Electronic Annotation
more info
 
3-oxo-pimeloyl-[acp] methyl ester reductase activity IEA
Inferred from Electronic Annotation
more info
 
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 
3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
 
NADPH binding ISO
Inferred from Sequence Orthology
more info
 
[acyl-carrier-protein] S-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
[acyl-carrier-protein] S-malonyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
acyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity IEA
Inferred from Electronic Annotation
more info
 
fatty acid synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid synthase activity ISO
Inferred from Sequence Orthology
more info
 
fatty acid synthase activity TAS
Traceable Author Statement
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
myristoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
oleoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
palmitoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphopantetheine binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acetyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
ether lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
monocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
glycogen granule IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion HDA PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007988.3NP_032014.3  fatty acid synthase

    See identical proteins and their annotated locations for NP_032014.3

    Status: VALIDATED

    Source sequence(s)
    AF127033, AK078721, AK080374, AK147694, CJ125823
    Consensus CDS
    CCDS25759.1
    UniProtKB/Swiss-Prot
    P19096
    Related
    ENSMUSP00000052872.7, ENSMUST00000055655.8
    Conserved Domains (11) summary
    cd05195
    Location:15591847
    enoyl_red; enoyl reductase of polyketide synthase
    cd08954
    Location:18692105
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:21182173
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:15571847
    PKS_ER; Enoylreductase
    COG3321
    Location:11015
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    cd00833
    Location:2404
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam00698
    Location:493810
    Acyl_transf_1; Acyl transferase domain
    pfam00975
    Location:22352494
    Thioesterase; Thioesterase domain
    pfam08242
    Location:12391337
    Methyltransf_12; Methyltransferase domain
    pfam16197
    Location:362474
    KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
    cl00509
    Location:8741106
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    120805958..120825166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245556.1XP_030101416.1  fatty acid synthase isoform X1

    Related
    ENSMUSP00000145585.1, ENSMUST00000206589.1
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