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Fasn fatty acid synthase [ Mus musculus (house mouse) ]

Gene ID: 14104, updated on 1-Mar-2024

Summary

Official Symbol
Fasnprovided by MGI
Official Full Name
fatty acid synthaseprovided by MGI
Primary source
MGI:MGI:95485
See related
Ensembl:ENSMUSG00000025153 AllianceGenome:MGI:95485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FAS; A630082H08Rik
Summary
Enables fatty acid synthase activity. Involved in ether lipid biosynthetic process; mammary gland development; and myeloid leukocyte differentiation. Acts upstream of or within cellular response to interleukin-4; epithelial cell development; and fatty acid biosynthetic process. Located in glycogen granule. Is expressed in several structures, including adipose tissue; alimentary system; nervous system; sensory organ; and skeleton. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 1605.0), subcutaneous fat pad adult (RPKM 1125.4) and 6 other tissues See more
Orthologs
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Genomic context

See Fasn in Genome Data Viewer
Location:
11 E2; 11 84.56 cM
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120696784..120715992, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120805958..120825166, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31368 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120657732-120657915 Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1 like Neighboring gene STARR-positive B cell enhancer ABC_E9039 Neighboring gene coiled-coil domain containing 57 Neighboring gene STARR-seq mESC enhancer starr_31373 Neighboring gene RIKEN cDNA A430102A20 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120794121-120794304

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables (3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables S-malonyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables [acyl-carrier-protein] S-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables [acyl-carrier-protein] S-malonyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity IEA
Inferred from Electronic Annotation
more info
 
enables fatty acid synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acid synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acid synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables fatty acid synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid synthase activity TAS
Traceable Author Statement
more info
PubMed 
enables fatty acyl-[ACP] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphopantetheine binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ether lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glandular epithelial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in modulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in monocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in glycogen granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fatty acid synthase
Names
type I Fatty Acid Synthase
NP_032014.3
XP_030101416.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007988.3NP_032014.3  fatty acid synthase

    See identical proteins and their annotated locations for NP_032014.3

    Status: VALIDATED

    Source sequence(s)
    AF127033, AK078721, AK080374, AK147694, CJ125823
    Consensus CDS
    CCDS25759.1
    UniProtKB/Swiss-Prot
    B1ATU8, P19096, Q6PB72, Q8C4Z0, Q9EQR0
    UniProtKB/TrEMBL
    Q3UHT6
    Related
    ENSMUSP00000052872.8, ENSMUST00000055655.9
    Conserved Domains (9) summary
    cd08954
    Location:18692105
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:21182173
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:15571847
    PKS_ER; Enoylreductase
    cd00833
    Location:2404
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam00698
    Location:493809
    Acyl_transf_1; Acyl transferase domain
    pfam08242
    Location:12391336
    Methyltransf_12; Methyltransferase domain
    pfam16197
    Location:362472
    KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
    cl00509
    Location:8741109
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
    cl21494
    Location:22352494
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120696784..120715992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245556.1XP_030101416.1  fatty acid synthase isoform X1

    UniProtKB/Swiss-Prot
    B1ATU8, P19096, Q6PB72, Q8C4Z0, Q9EQR0
    UniProtKB/TrEMBL
    Q3UHT6
    Related
    ENSMUSP00000145585.2, ENSMUST00000206589.2
    Conserved Domains (9) summary
    cd08954
    Location:18692105
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:21182173
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:15571847
    PKS_ER; Enoylreductase
    cd00833
    Location:2404
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam00698
    Location:493809
    Acyl_transf_1; Acyl transferase domain
    pfam08242
    Location:12391336
    Methyltransf_12; Methyltransferase domain
    pfam16197
    Location:362472
    KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
    cl00509
    Location:8741109
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
    cl21494
    Location:22352494
    Abhydrolase; alpha/beta hydrolases