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FASN fatty acid synthase [ Homo sapiens (human) ]

Gene ID: 2194, updated on 12-Aug-2018

Summary

Official Symbol
FASNprovided by HGNC
Official Full Name
fatty acid synthaseprovided by HGNC
Primary source
HGNC:HGNC:3594
See related
Ensembl:ENSG00000169710 MIM:600212; Vega:OTTHUMG00000178527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAS; OA-519; SDR27X1
Summary
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
Annotation information
Note: FAS (Gene ID: 355) and FASN (Gene ID: 2194) share the FAS symbol/alias in common. FAS is a widely used alternative name for fatty acid synthase (FASN), which can be confused with the official symbol for FAS (Fas cell surface death receptor, GeneID 355). [01 Jun 2018]
Expression
Biased expression in fat (RPKM 227.7), prostate (RPKM 28.4) and 3 other tissues See more
Orthologs

Genomic context

See FASN in Genome Data Viewer
Location:
17q25.3
Exon count:
43
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (82078338..82098303, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80036214..80056106, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1 like Neighboring gene small nucleolar RNA, C/D box 134 Neighboring gene coiled-coil domain containing 57 Neighboring gene solute carrier family 16 member 3 Neighboring gene microRNA 6787

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Cellular biotinylated fatty acid synthase protein (FASN) is incorporated into HIV-1 Gag virus-like particles PubMed
gag Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Vif vif HIV-1 Vif interacts with FASN PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14367, MGC15706

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-oxo-glutaryl-[acp] methyl ester reductase activity IEA
Inferred from Electronic Annotation
more info
 
3-oxo-pimeloyl-[acp] methyl ester reductase activity IEA
Inferred from Electronic Annotation
more info
 
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 
3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
 
NADPH binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
[acyl-carrier-protein] S-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
[acyl-carrier-protein] S-malonyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
drug binding IEA
Inferred from Electronic Annotation
more info
 
enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity IEA
Inferred from Electronic Annotation
more info
 
fatty acid synthase activity TAS
Traceable Author Statement
more info
 
myristoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
oleoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
palmitoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphopantetheine binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acetyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 
ether lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
mammary gland development IEA
Inferred from Electronic Annotation
more info
 
monocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
neutrophil differentiation IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation HDA PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cellular metabolic process TAS
Traceable Author Statement
more info
 
regulation of cholesterol biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
glycogen granule IEA
Inferred from Electronic Annotation
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
fatty acid synthase
Names
short chain dehydrogenase/reductase family 27X, member 1
NP_004095.4
XP_011521840.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004104.4NP_004095.4  fatty acid synthase

    See identical proteins and their annotated locations for NP_004095.4

    Status: REVIEWED

    Source sequence(s)
    BC007267, BC021544, BC063242, S80437
    Consensus CDS
    CCDS11801.1
    UniProtKB/Swiss-Prot
    P49327
    Related
    ENSP00000304592.2, OTTHUMP00000259630, ENST00000306749.3, OTTHUMT00000442369
    Conserved Domains (11) summary
    cd05195
    Location:15661854
    enoyl_red; enoyl reductase of polyketide synthase
    cd08954
    Location:18762112
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:21112179
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:15641854
    PKS_ER; Enoylreductase
    COG3321
    Location:11022
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    cd00833
    Location:2404
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam00698
    Location:493810
    Acyl_transf_1; Acyl transferase domain
    pfam00975
    Location:22422488
    Thioesterase; Thioesterase domain
    pfam08242
    Location:12431342
    Methyltransf_12; Methyltransferase domain
    pfam16197
    Location:362474
    KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
    cl00509
    Location:8741105
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    82078338..82098303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523538.2XP_011521840.1  fatty acid synthase isoform X1

    See identical proteins and their annotated locations for XP_011521840.1

    UniProtKB/Swiss-Prot
    P49327
    Conserved Domains (11) summary
    cd05195
    Location:15661854
    enoyl_red; enoyl reductase of polyketide synthase
    cd08954
    Location:18762112
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:21112179
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:15641854
    PKS_ER; Enoylreductase
    COG3321
    Location:11022
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    cd00833
    Location:2404
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam00698
    Location:493810
    Acyl_transf_1; Acyl transferase domain
    pfam00975
    Location:22422488
    Thioesterase; Thioesterase domain
    pfam08242
    Location:12431342
    Methyltransf_12; Methyltransferase domain
    pfam16197
    Location:362474
    KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
    cl00509
    Location:8741105
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
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