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STK35 serine/threonine kinase 35 [ Homo sapiens (human) ]

Gene ID: 140901, updated on 25-Nov-2021

Summary

Official Symbol
STK35provided by HGNC
Official Full Name
serine/threonine kinase 35provided by HGNC
Primary source
HGNC:HGNC:16254
See related
Ensembl:ENSG00000125834 MIM:609370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLIK1; STK35L1
Summary
The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 8.0), esophagus (RPKM 4.7) and 25 other tissues See more
Orthologs
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Genomic context

See STK35 in Genome Data Viewer
Location:
20p13
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (2098021..2148555)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (2082473..2129201)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene PDYN antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7514 Neighboring gene ribosomal protein L7 pseudogene 2 Neighboring gene uncharacterized LOC105372502 Neighboring gene uncharacterized LOC388780

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 35
Names
CLIK-1
CLP-36 interacting kinase
CLP-36-interacting kinase 1
PDLIM1-interacting kinase 1
serine threonine kinase 35 long form
serine/threonine-protein kinase 35 L1
NP_543026.2
XP_011527476.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080836.4NP_543026.2  serine/threonine-protein kinase 35

    See identical proteins and their annotated locations for NP_543026.2

    Status: REVIEWED

    Source sequence(s)
    AL359916, BC140884, GQ281297
    Consensus CDS
    CCDS13024.2
    UniProtKB/Swiss-Prot
    Q8TDR2
    Related
    ENSP00000370891.3, ENST00000381482.8
    Conserved Domains (2) summary
    smart00220
    Location:202523
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13977
    Location:201529
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    2098021..2148555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529174.3XP_011527476.1  serine/threonine-protein kinase 35 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:297395
    PKc_like; Protein Kinases, catalytic domain
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