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PABPC5 poly(A) binding protein cytoplasmic 5 [ Homo sapiens (human) ]

Gene ID: 140886, updated on 29-Mar-2023

Summary

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Official Symbol
PABPC5provided by HGNC
Official Full Name
poly(A) binding protein cytoplasmic 5provided by HGNC
Primary source
HGNC:HGNC:13629
See related
Ensembl:ENSG00000174740 MIM:300407; AllianceGenome:HGNC:13629
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PABP5
Summary
This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010]
Expression
Broad expression in ovary (RPKM 5.4), adrenal (RPKM 4.2) and 18 other tissues See more
Orthologs
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Genomic context

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See PABPC5 in Genome Data Viewer
Location:
Xq21.31
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (91434839..91438584)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (89886956..89890701)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (90689838..90693583)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TSC22 domain family protein 3-like Neighboring gene TSC22 domain family member 3 pseudogene Neighboring gene PABPC5 antisense RNA 1 Neighboring gene SERPINE1 mRNA binding protein 1 pseudogene 4 Neighboring gene uncharacterized LOC105373293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Depletion of nuclear poly(A) binding protein PABPN1 produces a compensatory response by cytoplasmic PABP4 and PABP5 in cultured human cells. Bhattacharjee RB, et al. PLoS One, 2012. PMID 23300856, Free PMC Article
  2. HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage. Castelló A, et al. PLoS One, 2009 Nov 24. PMID 19956697, Free PMC Article
  3. A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes. Blanco P, et al. Genomics, 2001 May 15. PMID 11374897
  4. Genetically distinct subsets within ANCA-associated vasculitis. Lyons PA, et al. N Engl J Med, 2012 Jul 19. PMID 22808956, Free PMC Article
  5. A large set of estrogen receptor β-interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei. Nassa G, et al. Proteomics, 2011 Jan. PMID 21182203

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetically distinct subsets within ANCA-associated vasculitis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR-induced PABP cleavage is involved in the inhibition of poly(A)-dependent translation. However, PABP cleavage has little impact on the translation of polyadenylated encephalomyocarditis virus internal ribosome entry site-containing mRNAs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ51677

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
polyadenylate-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021346.1 RefSeqGene

    Range
    5242..8987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080832.3 → NP_543022.1  polyadenylate-binding protein 5

    See identical proteins and their annotated locations for NP_543022.1

    Status: REVIEWED

    Source sequence(s)
    AL662874
    Consensus CDS
    CCDS14460.1
    UniProtKB/Swiss-Prot
    Q96DU9, Q9UFE5
    Related
    ENSP00000308012.3, ENST00000312600.4
    Conserved Domains (1) summary
    TIGR01628
    Location:22 → 379
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    91434839..91438584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    89886956..89890701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96DU9.1 GenPept UniProtKB/Swiss-Prot:Q96DU9