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RIPOR3 RIPOR family member 3 [ Homo sapiens (human) ]

Gene ID: 140876, updated on 7-Jun-2020

Summary

Official Symbol
RIPOR3provided by HGNC
Official Full Name
RIPOR family member 3provided by HGNC
Primary source
HGNC:HGNC:16168
See related
Ensembl:ENSG00000042062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM65C; C20orf175; C20orf176
Expression
Broad expression in bone marrow (RPKM 7.7), kidney (RPKM 6.8) and 22 other tissues See more
Orthologs

Genomic context

See RIPOR3 in Genome Data Viewer
Location:
20q13.13
Exon count:
30
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (50586108..50692004, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (49202645..49308277, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 1 Neighboring gene RNA, 7SL, cytoplasmic 672, pseudogene Neighboring gene microRNA 645 Neighboring gene microRNA 1302-5 Neighboring gene ribosomal protein L36 pseudogene 2 Neighboring gene RIPOR3 antisense RNA 1 Neighboring gene uncharacterized LOC105372659 Neighboring gene VISTA enhancer hs1860 Neighboring gene CRISPRi-validated cis-regulatory element chr20.2420 Neighboring gene par-6 family cell polarity regulator beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00360, FLJ32230

General protein information

Preferred Names
RIPOR family member 3
Names
family with sequence similarity 65 member C
protein FAM65C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034040.1 RefSeqGene

    Range
    4989..110423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290268.2NP_001277197.1  RIPOR family member 3 isoform 2

    See identical proteins and their annotated locations for NP_001277197.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate upstream AUG compared to variant 1. The encoded protein (isoform 2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AI056877, AK295781, AK299337, AL353653, AV703941, BM846795, BX111440, CD558804, CF272670, DC400584
    UniProtKB/TrEMBL
    B7Z3F0, B7Z5S0
    Related
    ENSP00000332663.3, ENST00000327979.8
    Conserved Domains (1) summary
    pfam15903
    Location:23367
    PL48; Filopodia upregulated, FAM65
  2. NM_080829.3NP_543019.2  RIPOR family member 3 isoform 1

    See identical proteins and their annotated locations for NP_543019.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter protein (isoform 1).
    Source sequence(s)
    AI056877, AK056792, AL133230, AL732057, CA389799, CF272670, CN268262, DC391298, DT932687
    Consensus CDS
    CCDS13431.2
    UniProtKB/Swiss-Prot
    Q96MK2
    Related
    ENSP00000045083.2, ENST00000045083.6
    Conserved Domains (1) summary
    pfam15903
    Location:19363
    PL48; Filopodia upregulated, FAM65

RNA

  1. NR_110890.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate first exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK295781, AK299337, AL353653, BQ446237, BX111440, CD558804, CF272670, DC365439, HY221639, HY285972

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    50586108..50692004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260294.3XP_005260351.1  RIPOR family member 3 isoform X1

    See identical proteins and their annotated locations for XP_005260351.1

    Conserved Domains (1) summary
    pfam15903
    Location:23367
    PL48; Filopodia upregulated, FAM65
  2. XM_011528578.2XP_011526880.1  RIPOR family member 3 isoform X1

    See identical proteins and their annotated locations for XP_011526880.1

    Conserved Domains (1) summary
    pfam15903
    Location:23367
    PL48; Filopodia upregulated, FAM65
  3. XM_006723713.4XP_006723776.1  RIPOR family member 3 isoform X3

    Conserved Domains (1) summary
    pfam15903
    Location:23362
    PL48; Filopodia upregulated, FAM65
  4. XM_011528579.2XP_011526881.1  RIPOR family member 3 isoform X2

    See identical proteins and their annotated locations for XP_011526881.1

    UniProtKB/Swiss-Prot
    Q96MK2
    Conserved Domains (1) summary
    pfam15903
    Location:19363
    PL48; Filopodia upregulated, FAM65
  5. XM_011528581.2XP_011526883.1  RIPOR family member 3 isoform X2

    See identical proteins and their annotated locations for XP_011526883.1

    UniProtKB/Swiss-Prot
    Q96MK2
    Conserved Domains (1) summary
    pfam15903
    Location:19363
    PL48; Filopodia upregulated, FAM65
  6. XM_011528580.2XP_011526882.1  RIPOR family member 3 isoform X2

    See identical proteins and their annotated locations for XP_011526882.1

    UniProtKB/Swiss-Prot
    Q96MK2
    Conserved Domains (1) summary
    pfam15903
    Location:19363
    PL48; Filopodia upregulated, FAM65
  7. XM_017027681.1XP_016883170.1  RIPOR family member 3 isoform X4

    Conserved Domains (1) summary
    pfam15903
    Location:1137
    PL48; Filopodia upregulated, FAM65
  8. XM_011528585.2XP_011526887.1  RIPOR family member 3 isoform X6

    Conserved Domains (2) summary
    PHA03089
    Location:433474
    PHA03089; late transcription factor VLTF-4; Provisional
    pfam15903
    Location:130
    PL48; Filopodia upregulated, FAM65
  9. XM_011528584.3XP_011526886.1  RIPOR family member 3 isoform X5

    Conserved Domains (1) summary
    pfam15903
    Location:23367
    PL48; Filopodia upregulated, FAM65
  10. XM_011528586.2XP_011526888.1  RIPOR family member 3 isoform X7

    Conserved Domains (1) summary
    pfam15903
    Location:23367
    PL48; Filopodia upregulated, FAM65
  11. XM_017027682.2XP_016883171.1  RIPOR family member 3 isoform X8

    Conserved Domains (1) summary
    pfam15903
    Location:23367
    PL48; Filopodia upregulated, FAM65

RNA

  1. XR_001754183.1 RNA Sequence

  2. XR_936505.2 RNA Sequence

  3. XR_936506.3 RNA Sequence

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