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Faf1 Fas-associated factor 1 [ Mus musculus (house mouse) ]

Gene ID: 14084, updated on 30-Apr-2024

Summary

Official Symbol
Faf1provided by MGI
Official Full Name
Fas-associated factor 1provided by MGI
Primary source
MGI:MGI:109419
See related
Ensembl:ENSMUSG00000010517 AllianceGenome:MGI:109419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam; Dffrx
Summary
Enables protein domain specific binding activity. Acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and regulation of cell adhesion. Located in cytoplasm and nuclear envelope. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human FAF1 (Fas associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 10.0), CNS E18 (RPKM 8.3) and 28 other tissues See more
Orthologs
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Genomic context

See Faf1 in Genome Data Viewer
Location:
4 C7; 4 51.33 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (109533873..109821157)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109676627..109963960)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9630013D21 gene Neighboring gene cyclin dependent kinase inhibitor 2C Neighboring gene STARR-seq mESC enhancer starr_11075 Neighboring gene STARR-seq mESC enhancer starr_11076 Neighboring gene doublesex and mab-3 related transcription factor like family A2, opposite strand Neighboring gene doublesex and mab-3 related transcription factor like family A2 Neighboring gene STARR-seq mESC enhancer starr_11077 Neighboring gene predicted gene, 33070

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NF-kappaB binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of VCP-NPL4-UFD1 AAA ATPase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in ooplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418777.1NP_001405706.1  FAS-associated factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627188, AL627392
  2. NM_007983.3NP_032009.2  FAS-associated factor 1 isoform 1

    See identical proteins and their annotated locations for NP_032009.2

    Status: VALIDATED

    Source sequence(s)
    AL627188, AL627392
    Consensus CDS
    CCDS18468.1
    UniProtKB/Swiss-Prot
    P54731, Q6P1F8
    Related
    ENSMUSP00000099785.5, ENSMUST00000102724.5
    Conserved Domains (4) summary
    cd01771
    Location:569648
    Faf1_UBX; Faf1 UBX domain
    cd02990
    Location:351486
    UAS_FAF1; UAS family, FAS-associated factor 1 (FAF1) subfamily; FAF1 contains a UAS domain of unknown function N-terminal to a ubiquitin-associated UBX domain. FAF1 also contains ubiquitin-associated UBA and nuclear targeting domains, N-terminal to the UAS domain. ...
    cd14413
    Location:1446
    UBA_FAF1; UBA-like domain found in FAS-associated factor 1 (FAF1) and similar proteins
    pfam00836
    Location:470558
    Stathmin; Stathmin family

RNA

  1. NR_184814.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627188, AL627392
  2. NR_184815.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627188, AL627392
  3. NR_184816.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627188, AL627392

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    109533873..109821157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)