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BANF2 BANF family member 2 [ Homo sapiens (human) ]

Gene ID: 140836, updated on 13-Aug-2022

Summary

Official Symbol
BANF2provided by HGNC
Official Full Name
BANF family member 2provided by HGNC
Primary source
HGNC:HGNC:16172
See related
Ensembl:ENSG00000125888 AllianceGenome:HGNC:16172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAF2; BAFL; BAF-L; C20orf179
Summary
Enables identical protein binding activity. Predicted to be involved in chromosome condensation and chromosome segregation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 14.5) See more
Orthologs
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Genomic context

See BANF2 in Genome Data Viewer
Location:
20p12.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (17693672..17735871)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (17744826..17787013)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (17674317..17716516)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ras homolog family member G pseudogene Neighboring gene destrin, actin depolymerizing factor Neighboring gene ribosome binding protein 1 Neighboring gene Sharpr-MPRA regulatory region 8855 Neighboring gene uncharacterized LOC105372547 Neighboring gene uncharacterized LOC107985440 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:17829988-17831187 Neighboring gene uncharacterized LOC105372548

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC62093, MGC72082

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
barrier-to-autointegration factor-like protein
Names
barrier to autointegration factor 2
testis secretory sperm-binding protein Li 212a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014977.4NP_001014977.2  barrier-to-autointegration factor-like protein isoform 1

    See identical proteins and their annotated locations for NP_001014977.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA394107, AW022487, BC054871
    Consensus CDS
    CCDS13129.1
    UniProtKB/Swiss-Prot
    Q7Z4M6, Q9H503
    UniProtKB/TrEMBL
    A0A140VK85
    Related
    ENSP00000367036.3, ENST00000377805.7
    Conserved Domains (1) summary
    cl03803
    Location:389
    BAF; Barrier to autointegration factor
  2. NM_001159495.2NP_001152967.1  barrier-to-autointegration factor-like protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon and an upstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AA394107, AL132765, AW022487
    Consensus CDS
    CCDS54449.1
    UniProtKB/Swiss-Prot
    Q9H503
    Related
    ENSP00000439128.1, ENST00000545418.2
    Conserved Domains (1) summary
    cl03803
    Location:1096
    BAF; Barrier to autointegration factor
  3. NM_178477.5NP_848572.3  barrier-to-autointegration factor-like protein isoform 1

    See identical proteins and their annotated locations for NP_848572.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript but encodes the shorter isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA394107, AW022487, BC054871, BC062735
    Consensus CDS
    CCDS13129.1
    UniProtKB/Swiss-Prot
    Q7Z4M6, Q9H503
    UniProtKB/TrEMBL
    A0A140VK85
    Related
    ENSP00000246090.5, ENST00000246090.6
    Conserved Domains (1) summary
    cl03803
    Location:389
    BAF; Barrier to autointegration factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    17693672..17735871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260668.4XP_005260725.1  barrier-to-autointegration factor-like protein isoform X2

    See identical proteins and their annotated locations for XP_005260725.1

    UniProtKB/Swiss-Prot
    Q7Z4M6, Q9H503
    UniProtKB/TrEMBL
    A0A140VK85
    Conserved Domains (1) summary
    cl03803
    Location:389
    BAF; Barrier to autointegration factor
  2. XM_011529170.2XP_011527472.1  barrier-to-autointegration factor-like protein isoform X1

    See identical proteins and their annotated locations for XP_011527472.1

    Conserved Domains (1) summary
    cl03803
    Location:894
    BAF; Barrier to autointegration factor
  3. XM_011529171.4XP_011527473.1  barrier-to-autointegration factor-like protein isoform X1

    See identical proteins and their annotated locations for XP_011527473.1

    Conserved Domains (1) summary
    cl03803
    Location:894
    BAF; Barrier to autointegration factor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    17744826..17787013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)