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Fadd Fas associated via death domain [ Mus musculus (house mouse) ]

Gene ID: 14082, updated on 8-Feb-2024

Summary

Official Symbol
Faddprovided by MGI
Official Full Name
Fas associated via death domainprovided by MGI
Primary source
MGI:MGI:109324
See related
Ensembl:ENSMUSG00000031077 AllianceGenome:MGI:109324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mort1/FADD
Summary
Predicted to enable several functions, including caspase binding activity; death effector domain binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of activation-induced cell death of T cells; and positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and regulation of programmed cell death. Predicted to be located in several cellular components, including cell body; cytosol; and membrane raft. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 10.0), large intestine adult (RPKM 9.9) and 28 other tissues See more
Orthologs
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Genomic context

See Fadd in Genome Data Viewer
Location:
7 F5; 7 88.85 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144132060..144136178, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (144578323..144582441, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cortactin Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 Neighboring gene STARR-positive B cell enhancer ABC_E6619 Neighboring gene STARR-positive B cell enhancer ABC_E9306 Neighboring gene predicted gene, 35626 Neighboring gene anoctamin 1, calcium activated chloride channel Neighboring gene RIKEN cDNA D930030F02 gene Neighboring gene predicted gene, 34964

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables caspase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables caspase binding ISO
Inferred from Sequence Orthology
more info
 
enables death effector domain binding ISO
Inferred from Sequence Orthology
more info
 
enables death receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables death receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor superfamily binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in TRAIL-activated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
involved_in death-inducing signaling complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in lymph node development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in necroptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of adaptive immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of execution phase of apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in spleen development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in thymus development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of CD95 death-inducing signaling complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CD95 death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ripoptosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
FAS-associated death domain protein
Names
FAS-associating death domain-containing protein
Fas (TNFRSF6)-associated via death domain
Fas-associating protein with death domain
mediator of receptor induced toxicity
protein FADD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010175.6NP_034305.1  FAS-associated death domain protein

    See identical proteins and their annotated locations for NP_034305.1

    Status: VALIDATED

    Source sequence(s)
    AC153792
    Consensus CDS
    CCDS22050.1
    UniProtKB/Swiss-Prot
    Q3TC37, Q61082, Q61160
    UniProtKB/TrEMBL
    Q8CD57
    Related
    ENSMUSP00000033394.8, ENSMUST00000033394.8
    Conserved Domains (2) summary
    cd08306
    Location:97181
    Death_FADD; Fas-associated Death Domain protein-protein interaction domain
    cd08336
    Location:283
    DED_FADD; Death Effector Domain found in Fas-Associated via Death Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    144132060..144136178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)