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FADD Fas associated via death domain [ Homo sapiens (human) ]

Gene ID: 8772, updated on 27-Nov-2024

Summary

Official Symbol
FADDprovided by HGNC
Official Full Name
Fas associated via death domainprovided by HGNC
Primary source
HGNC:HGNC:3573
See related
Ensembl:ENSG00000168040 MIM:602457; AllianceGenome:HGNC:3573
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIG3; IMD90; MORT1
Summary
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 9.3), colon (RPKM 8.7) and 25 other tissues See more
Orthologs
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Genomic context

See FADD in Genome Data Viewer
Location:
11q13.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (70203296..70207390)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (70218250..70222344)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (70049402..70053496)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene anoctamin 1 Neighboring gene RNA, U6 small nuclear 1175, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr11:69935765-69935935 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:69938122-69938334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69939545-69940046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69940047-69940546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69945353-69946112 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:69962362-69962862 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:69962863-69963363 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69969469-69970107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69974897-69975729 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:69980445-69981644 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:69986885-69987698 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:69987699-69988510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70001450-70001950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70001951-70002451 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70008633-70008799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70016639-70017140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70017141-70017640 Neighboring gene uncharacterized LOC101928473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70020559-70021264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5161 Neighboring gene Sharpr-MPRA regulatory region 13422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:70042837-70043336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3699 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70049941-70050132 Neighboring gene uncharacterized LOC124902705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70058905-70059714 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70059715-70060524 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70060525-70061332 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:70065875-70066575 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:70075454-70075954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3701 Neighboring gene PTPRF interacting protein alpha 1 Neighboring gene H2A.Z histone pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neuron apoptosis requires the upregulation of the death receptor Fas and its associated death proteins, FADD and CASP8 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC8528

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables caspase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables caspase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables caspase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables death effector domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables death receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor serine/threonine kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables tumor necrosis factor receptor superfamily binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell differentiation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in T cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in TRAIL-activated apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in death-inducing signaling complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
 
involved_in lymph node development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in motor neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in necroptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of activation-induced cell death of T cells ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of necroptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of activated T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type II interferon production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spleen development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in thymus development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of CD95 death-inducing signaling complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CD95 death-inducing signaling complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic side of plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of death-inducing signaling complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of death-inducing signaling complex TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of ripoptosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
FAS-associated death domain protein
Names
Fas (TNFRSF6)-associated via death domain
Fas-associating death domain-containing protein
Fas-associating protein with death domain
growth-inhibiting gene 3 protein
mediator of receptor-induced toxicity

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027966.1 RefSeqGene

    Range
    5001..9240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_228

mRNA and Protein(s)

  1. NM_003824.4NP_003815.1  FAS-associated death domain protein

    See identical proteins and their annotated locations for NP_003815.1

    Status: REVIEWED

    Source sequence(s)
    AI886015, AL575732, AP000879, BC000334
    Consensus CDS
    CCDS8196.1
    UniProtKB/Swiss-Prot
    Q13158, Q14866, Q6IBR4
    Related
    ENSP00000301838.5, ENST00000301838.5
    Conserved Domains (2) summary
    cd08306
    Location:97181
    Death_FADD; Fas-associated Death Domain protein-protein interaction domain
    cd08336
    Location:2482
    DED_FADD; Death Effector Domain found in Fas-Associated via Death Domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    70203296..70207390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    70218250..70222344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)