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FADD Fas associated via death domain [ Homo sapiens (human) ]

Gene ID: 8772, updated on 13-Mar-2020

Summary

Official Symbol
FADDprovided by HGNC
Official Full Name
Fas associated via death domainprovided by HGNC
Primary source
HGNC:HGNC:3573
See related
Ensembl:ENSG00000168040 MIM:602457
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIG3; MORT1
Summary
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 9.3), colon (RPKM 8.7) and 25 other tissues See more
Orthologs

Genomic context

See FADD in Genome Data Viewer
Location:
11q13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (70203296..70207390)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (70049269..70053508)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene anoctamin 1 Neighboring gene uncharacterized LOC105369372 Neighboring gene uncharacterized LOC101928473 Neighboring gene PTPRF interacting protein alpha 1 Neighboring gene H2A.Z histone pseudogene 4 Neighboring gene microRNA 548k

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neuron apoptosis requires the upregulation of the death receptor Fas and its associated death proteins, FADD and CASP8 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC8528

Gene Ontology Provided by GOA

Function Evidence Code Pubs
caspase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
caspase binding IPI
Inferred from Physical Interaction
more info
PubMed 
death effector domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
death receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
receptor serine/threonine kinase binding IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor receptor superfamily binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell differentiation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
TRAIL-activated apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TRAIL-activated apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
death-inducing signaling complex assembly TAS
Traceable Author Statement
more info
 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
extrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
kidney development IEA
Inferred from Electronic Annotation
more info
 
lymph node development ISS
Inferred from Sequence or Structural Similarity
more info
 
motor neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
necroptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of activation-induced cell death of T cells ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 
negative regulation of necroptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of T cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of activated T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-gamma production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
spleen development ISS
Inferred from Sequence or Structural Similarity
more info
 
thymus development ISS
Inferred from Sequence or Structural Similarity
more info
 
toll-like receptor 3 signaling pathway TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
CD95 death-inducing signaling complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CD95 death-inducing signaling complex IDA
Inferred from Direct Assay
more info
PubMed 
cell body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
death-inducing signaling complex IDA
Inferred from Direct Assay
more info
PubMed 
death-inducing signaling complex TAS
Traceable Author Statement
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
ripoptosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
FAS-associated death domain protein
Names
Fas (TNFRSF6)-associated via death domain
Fas-associating death domain-containing protein
Fas-associating protein with death domain
growth-inhibiting gene 3 protein
mediator of receptor-induced toxicity

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027966.1 RefSeqGene

    Range
    5001..9240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_228

mRNA and Protein(s)

  1. NM_003824.4NP_003815.1  FAS-associated death domain protein

    See identical proteins and their annotated locations for NP_003815.1

    Status: REVIEWED

    Source sequence(s)
    AI886015, AL575732, AP000879, BC000334
    Consensus CDS
    CCDS8196.1
    UniProtKB/Swiss-Prot
    Q13158
    Related
    ENSP00000301838.4, ENST00000301838.4
    Conserved Domains (2) summary
    cd08306
    Location:97181
    Death_FADD; Fas-associated Death Domain protein-protein interaction domain
    cd08336
    Location:2482
    DED_FADD; Death Effector Domain found in Fas-Associated via Death Domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    70203296..70207390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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