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Acsl1 acyl-CoA synthetase long-chain family member 1 [ Mus musculus (house mouse) ]

Gene ID: 14081, updated on 18-Dec-2022

Summary

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Official Symbol
Acsl1provided by MGI
Official Full Name
acyl-CoA synthetase long-chain family member 1provided by MGI
Primary source
MGI:MGI:102797
See related
Ensembl:ENSMUSG00000018796 AllianceGenome:MGI:102797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acs; Acas; FACS; Acas1; Facl2; LACS1; LACS 1
Summary
The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Biased expression in liver E18 (RPKM 94.6), subcutaneous fat pad adult (RPKM 79.5) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Acsl1 in Genome Data Viewer
Location:
8; 8 B1.1
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (46924074..46989088)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (46471037..46536051)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39168 Neighboring gene predicted gene, 30931 Neighboring gene centromere protein U Neighboring gene primase and polymerase (DNA-directed) Neighboring gene predicted gene 45607

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting ACSL1 promotes cardiomyocyte proliferation and cardiac regeneration. Li Y, et al. Life Sci, 2022 Apr 1. PMID 35122795
  2. Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus Infection. Xia H, et al. Viruses, 2021 Nov 28. PMID 34960652, Free PMC Article
  3. An Essential Role of the N-Terminal Region of ACSL1 in Linking Free Fatty Acids to Mitochondrial β-Oxidation in C2C12 Myotubes. Nan J, et al. Mol Cells, 2021 Sep 30. PMID 34511469, Free PMC Article
  4. Mouse long-chain acyl-CoA synthetase 1 is active as a monomer. Dykstra H, et al. Arch Biochem Biophys, 2021 Mar 30. PMID 33485846
  5. Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia. Khamoui AV, et al. Physiol Genomics, 2020 May 1. PMID 32146873, Free PMC Article

See all (74) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol-induced steatohepatitis.
    Title: Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol-induced steatohepatitis.
  2. Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation.
    Title: Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation.
  3. Targeting ACSL1 promotes cardiomyocyte proliferation and cardiac regeneration.
    Title: Targeting ACSL1 promotes cardiomyocyte proliferation and cardiac regeneration.
  4. An Essential Role of the N-Terminal Region of ACSL1 in Linking Free Fatty Acids to Mitochondrial beta-Oxidation in C2C12 Myotubes.
    Title: An Essential Role of the N-Terminal Region of ACSL1 in Linking Free Fatty Acids to Mitochondrial β-Oxidation in C2C12 Myotubes.
  5. Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus Infection.
    Title: Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus Infection.
  6. TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation.
    Title: TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation.
  7. Mouse long-chain acyl-CoA synthetase 1 is active as a monomer.
    Title: Mouse long-chain acyl-CoA synthetase 1 is active as a monomer.
  8. Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia.
    Title: Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia.
  9. loss of ACSL1 in macrophages decreases fatty acid crystal formation thereby reducing lysosome damage and IL-1beta release.
    Title: Frontline Science: Acyl-CoA synthetase 1 exacerbates lipotoxic inflammasome activation in primary macrophages.
  10. ACSL1 deficiency produces an overall defect in muscle fuel metabolism that increases protein catabolism, resulting in exercise intolerance, muscle weakness, and myocyte apoptosis.
    Title: Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables arachidonate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oleoyl-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables phytanate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adiponectin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid import into cell ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in long-chain fatty-acyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of long-chain fatty acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to organic substance ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in very long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase 1
Names
acetate-CoA ligase
acetyl-CoA synthetase
acetyl-Coenzyme A synthetase 1 (ADP forming)
arachidonate--CoA ligase
fatty acid Coenzyme A ligase, long chain 2
long-chain acyl-CoA synthetase 1
phytanate--CoA ligase
NP_001289092.1
NP_032007.2
XP_006509325.2
XP_006509327.1
XP_006509328.1
XP_006509329.1
XP_017168052.1
XP_030099145.1
XP_036009645.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302163.1 → NP_001289092.1  long-chain-fatty-acid--CoA ligase 1

    See identical proteins and their annotated locations for NP_001289092.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC119267, AC138367, AK149406, BY094311, BY142492, BY393025
    Consensus CDS
    CCDS22291.1
    UniProtKB/Swiss-Prot
    P41216, Q9DBK5
    Related
    ENSMUSP00000106001.2, ENSMUST00000110372.9
    Conserved Domains (1) summary
    cd05927
    Location:117 → 695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. NM_007981.4 → NP_032007.2  long-chain-fatty-acid--CoA ligase 1

    See identical proteins and their annotated locations for NP_032007.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a distinct 5' UTR and represents use of an alternate promoter compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC119267, AC138367, AK149406, BY393025, BY786934
    Consensus CDS
    CCDS22291.1
    UniProtKB/Swiss-Prot
    P41216, Q9DBK5
    Related
    ENSMUSP00000034046.6, ENSMUST00000034046.13
    Conserved Domains (1) summary
    cd05927
    Location:117 → 695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    46924074..46989088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509264.5 → XP_006509327.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509327.1

    UniProtKB/Swiss-Prot
    P41216, Q9DBK5
    Conserved Domains (1) summary
    cd05927
    Location:117 → 695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. XM_017312563.3 → XP_017168052.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    UniProtKB/Swiss-Prot
    P41216, Q9DBK5
    Conserved Domains (1) summary
    cd05927
    Location:117 → 695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  3. XM_006509266.4 → XP_006509329.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509329.1

    UniProtKB/Swiss-Prot
    P41216, Q9DBK5
    Conserved Domains (1) summary
    cd05927
    Location:117 → 695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  4. XM_006509265.4 → XP_006509328.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509328.1

    UniProtKB/Swiss-Prot
    P41216, Q9DBK5
    Conserved Domains (1) summary
    cd05927
    Location:117 → 695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  5. XM_030243285.2 → XP_030099145.1  long-chain-fatty-acid--CoA ligase 1 isoform X3

    UniProtKB/TrEMBL
    D3Z041
    Related
    ENSMUSP00000106000.2, ENSMUST00000110371.8
    Conserved Domains (1) summary
    cd05927
    Location:117 → 695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  6. XM_006509262.4 → XP_006509325.2  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509325.2

    UniProtKB/Swiss-Prot
    P41216, Q9DBK5
    Conserved Domains (1) summary
    cd05927
    Location:117 → 695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  7. XM_036153752.1 → XP_036009645.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

    Conserved Domains (1) summary
    cl17068
    Location:1 → 370
    AFD_class_I; Adenylate forming domain, Class I superfamily

RNA

  1. XR_004934769.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41216.2 GenPept UniProtKB/Swiss-Prot:P41216

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