Format

Send to:

Choose Destination

Acsl1 acyl-CoA synthetase long-chain family member 1 [ Mus musculus (house mouse) ]

Gene ID: 14081, updated on 12-Aug-2018
Official Symbol
Acsl1provided by MGI
Official Full Name
acyl-CoA synthetase long-chain family member 1provided by MGI
Primary source
MGI:MGI:102797
See related
Ensembl:ENSMUSG00000018796 Vega:OTTMUSG00000022668
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acs; Acas; FACS; Acas1; Facl2; LACS1; LACS 1
Summary
The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Biased expression in liver E18 (RPKM 94.6), subcutaneous fat pad adult (RPKM 79.5) and 13 other tissues See more
Orthologs
See Acsl1 in Genome Data Viewer
Location:
8; 8 B1.1
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (46471037..46536051)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (47556396..47621404)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30931 Neighboring gene predicted gene, 31050 Neighboring gene centromere protein U Neighboring gene primase and polymerase (DNA-directed) Neighboring gene caspase 3

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
acetate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
decanoate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adiponectin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid transport ISO
Inferred from Sequence Orthology
more info
 
lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid import ISO
Inferred from Sequence Orthology
more info
 
long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
long-chain fatty-acyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
peroxisome IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
long-chain-fatty-acid--CoA ligase 1
Names
acetate-CoA ligase
acetyl-CoA synthetase
acetyl-Coenzyme A synthetase 1 (ADP forming)
fatty acid Coenzyme A ligase, long chain 2
long-chain acyl-CoA synthetase 1
NP_001289092.1
NP_032007.2
XP_006509325.2
XP_006509327.1
XP_006509328.1
XP_006509329.1
XP_017168052.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302163.1NP_001289092.1  long-chain-fatty-acid--CoA ligase 1

    See identical proteins and their annotated locations for NP_001289092.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC138367, AK149406, BY094311, BY142492, BY393025
    Consensus CDS
    CCDS22291.1
    UniProtKB/Swiss-Prot
    P41216
    Related
    ENSMUSP00000106001.1, OTTMUSP00000025910, ENSMUST00000110372.8, OTTMUST00000054313
    Conserved Domains (2) summary
    PLN02736
    Location:87697
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:117694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  2. NM_007981.4NP_032007.2  long-chain-fatty-acid--CoA ligase 1

    See identical proteins and their annotated locations for NP_032007.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a distinct 5' UTR and represents use of an alternate promoter compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC138367, AK149406, BY393025, BY786934
    Consensus CDS
    CCDS22291.1
    UniProtKB/Swiss-Prot
    P41216
    Related
    ENSMUSP00000034046.5, OTTMUSP00000025909, ENSMUST00000034046.12, OTTMUST00000054312
    Conserved Domains (2) summary
    PLN02736
    Location:87697
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:117694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    46471037..46536051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509264.3XP_006509327.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509327.1

    UniProtKB/Swiss-Prot
    P41216
    Conserved Domains (2) summary
    PLN02736
    Location:87697
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:117694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  2. XM_017312563.1XP_017168052.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    UniProtKB/Swiss-Prot
    P41216
    Related
    ENSMUSP00000106000.1, OTTMUSP00000025912, ENSMUST00000110371.7, OTTMUST00000054316
    Conserved Domains (2) summary
    PLN02736
    Location:87697
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:117694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  3. XM_006509266.2XP_006509329.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509329.1

    UniProtKB/Swiss-Prot
    P41216
    Conserved Domains (2) summary
    PLN02736
    Location:87697
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:117694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  4. XM_006509265.2XP_006509328.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509328.1

    UniProtKB/Swiss-Prot
    P41216
    Conserved Domains (2) summary
    PLN02736
    Location:87697
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:117694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  5. XM_006509262.3XP_006509325.2  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509325.2

    UniProtKB/Swiss-Prot
    P41216
    Conserved Domains (2) summary
    PLN02736
    Location:87697
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:117694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
Support Center