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ACSL1 acyl-CoA synthetase long chain family member 1 [ Homo sapiens (human) ]

Gene ID: 2180, updated on 25-Nov-2021

Summary

Official Symbol
ACSL1provided by HGNC
Official Full Name
acyl-CoA synthetase long chain family member 1provided by HGNC
Primary source
HGNC:HGNC:3569
See related
Ensembl:ENSG00000151726 MIM:152425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACS1; LACS; FACL1; FACL2; LACS1; LACS2
Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Expression
Biased expression in fat (RPKM 357.3), liver (RPKM 217.4) and 10 other tissues See more
Orthologs
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Genomic context

See ACSL1 in Genome Data Viewer
Location:
4q35.1
Exon count:
31
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (184755595..184826593, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (185676749..185747122, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene caspase 3 Neighboring gene primase and DNA directed polymerase Neighboring gene centromere protein U Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 pseudogene Neighboring gene uncharacterized LOC105377587 Neighboring gene MIR3945 host gene Neighboring gene microRNA 3945

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables arachidonate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arachidonate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
 
enables oleoyl-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phytanate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables pristanate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adiponectin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid import into cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid import into cell ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of long-chain fatty acid import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oleic acid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in very long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
long-chain-fatty-acid--CoA ligase 1
Names
LACS 1
LACS 2
acyl-CoA synthetase 1
arachidonate--CoA ligase
fatty-acid-Coenzyme A ligase, long-chain 1
fatty-acid-Coenzyme A ligase, long-chain 2
lignoceroyl-CoA synthase
long-chain acyl-CoA synthetase 1
long-chain acyl-CoA synthetase 2
long-chain fatty acid-CoA ligase 2
long-chain fatty-acid-coenzyme A ligase 1
palmitoyl-CoA ligase 1
palmitoyl-CoA ligase 2
paltimoyl-CoA ligase 1
phytanate--CoA ligase
NP_001273637.1
NP_001273639.1
NP_001273640.1
NP_001368806.1
NP_001368807.1
NP_001368808.1
NP_001368809.1
NP_001368810.1
NP_001368811.1
NP_001368812.1
NP_001368813.1
NP_001368814.1
NP_001368815.1
NP_001368816.1
NP_001368817.1
NP_001368818.1
NP_001368819.1
NP_001986.2
XP_016863376.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286708.2NP_001273637.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    See identical proteins and their annotated locations for NP_001273637.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 6-12 all encode the same isoform (a).
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS3839.1
    UniProtKB/Swiss-Prot
    P33121
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000425006.1, ENST00000504342.5
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  2. NM_001286710.2NP_001273639.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    See identical proteins and their annotated locations for NP_001273639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has an alternate in-frame exon in place of another in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini and is the same length but has an alternate internal segment compared to isoform a. Variants 3 and 13-16 all encode the same isoform (b).
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS68826.1
    UniProtKB/Swiss-Prot
    P33121
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000426150.1, ENST00000513317.5
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  3. NM_001286711.2NP_001273640.1  long-chain-fatty-acid--CoA ligase 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS68825.1
    UniProtKB/Swiss-Prot
    P33121
    UniProtKB/TrEMBL
    A8K9T3, B4E0R0, E7EPM6
    Related
    ENSP00000426244.1, ENST00000507295.5
    Conserved Domains (2) summary
    PLN02736
    Location:86662
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:116659
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  4. NM_001381877.1NP_001368806.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, and 7-12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  5. NM_001381878.1NP_001368807.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 2, 6, and 8-12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  6. NM_001381879.1NP_001368808.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 2, 6, 7, and 9-12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  7. NM_001381880.1NP_001368809.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 1, 2, 6-8, and 10-12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  8. NM_001381881.1NP_001368810.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 2, 6-9, 11, and 12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  9. NM_001381882.1NP_001368811.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1, 2, 6-10, and 12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  10. NM_001381883.1NP_001368812.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 1, 2, and 6-11, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  11. NM_001381884.1NP_001368813.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 3 and 14-16, encodes isoform b.
    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  12. NM_001381885.1NP_001368814.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 3, 13, 15, and 16, encodes isoform b.
    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  13. NM_001381886.1NP_001368815.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 3, 13, 14, and 16, encodes isoform b.
    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  14. NM_001381887.1NP_001368816.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 3 and 13-15, encodes isoform b.
    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  15. NM_001381888.1NP_001368817.1  long-chain-fatty-acid--CoA ligase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 18, encodes isoform e.
    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:67645
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  16. NM_001381889.1NP_001368818.1  long-chain-fatty-acid--CoA ligase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 17, encodes isoform e.
    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:67645
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  17. NM_001381890.1NP_001368819.1  long-chain-fatty-acid--CoA ligase 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
    Conserved Domains (1) summary
    cd05927
    Location:52630
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  18. NM_001995.5NP_001986.2  long-chain-fatty-acid--CoA ligase 1 isoform a

    See identical proteins and their annotated locations for NP_001986.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 6-12 all encode the same isoform (a).
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS3839.1
    UniProtKB/Swiss-Prot
    P33121
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000281455.2, ENST00000281455.7
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RNA

  1. NR_167698.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  2. NR_167702.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  3. NR_167703.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
    Related
    ENST00000454703.6
  4. NR_167704.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  5. NR_167705.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  6. NR_167706.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  7. NR_167708.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  8. NR_167709.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    184755595..184826593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007887.1XP_016863376.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    UniProtKB/Swiss-Prot
    P33121
    Related
    ENSP00000422607.1, ENST00000515030.5
    Conserved Domains (1) summary
    cd05927
    Location:116694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001286712.1: Suppressed sequence

    Description
    NM_001286712.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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