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ACSL1 acyl-CoA synthetase long chain family member 1 [ Homo sapiens (human) ]

Gene ID: 2180, updated on 25-Nov-2025
Official Symbol
ACSL1provided by HGNC
Official Full Name
acyl-CoA synthetase long chain family member 1provided by HGNC
Primary source
HGNC:HGNC:3569
See related
Ensembl:ENSG00000151726 MIM:152425; AllianceGenome:HGNC:3569
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACS1; LACS; FACL1; FACL2; LACS1; LACS2
Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Expression
Biased expression in fat (RPKM 357.3), liver (RPKM 217.4) and 10 other tissues See more
Orthologs
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See ACSL1 in Genome Data Viewer
Location:
4q35.1
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (184755595..184826594, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (188099036..188170021, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (185676749..185747122, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:185564061-185564639 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:185564640-185565217 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:185565519-185566150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15841 Neighboring gene caspase 3 Neighboring gene primase and DNA directed polymerase Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:185609328-185610527 Neighboring gene centromere protein U Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15842 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:185654690-185655556 Neighboring gene NANOG hESC enhancer GRCh37_chr4:185657064-185657583 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:185668497-185668998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22233 Neighboring gene NANOG hESC enhancer GRCh37_chr4:185729525-185730070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22239 Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:185747691-185748194 Neighboring gene ACSL1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22243 Neighboring gene MIR3945 host gene Neighboring gene microRNA 3945 Neighboring gene PATRR4 recombination region Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:185814744-185815943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22244 Neighboring gene long intergenic non-protein coding RNA 1093

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Chromosomal localization of the human gene for palmitoyl-CoA ligase (FACL1). Stanczak H, et al. Cytogenet Cell Genet, 1992. PMID 1531127
  2. Eicosapentaenoic acid suppresses palmitate-induced cytokine production by modulating long-chain acyl-CoA synthetase 1 expression in human THP-1 macrophages. Nakakuki M, et al. Atherosclerosis, 2013 Apr. PMID 23433401
  3. Acyl coenzyme A synthetase long-chain 1 (ACSL1) gene polymorphism (rs6552828) and elite endurance athletic status: a replication study. Yvert T, et al. PLoS One, 2012. PMID 22829935, Free PMC Article
  4. Genetic association of long-chain acyl-CoA synthetase 1 variants with fasting glucose, diabetes, and subclinical atherosclerosis. Manichaikul A, et al. J Lipid Res, 2016 Mar. PMID 26711138, Free PMC Article
  5. 3'UTR Polymorphism in ACSL1 Gene Correlates with Expression Levels and Poor Clinical Outcome in Colon Cancer Patients. Vargas T, et al. PLoS One, 2016. PMID 27992526, Free PMC Article

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy.
    Title: The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy.
  2. ACSL1-Mediated Fatty Acid beta-Oxidation Enhances Metastasis and Proliferation in Endometrial Cancer.
    Title: ACSL1-Mediated Fatty Acid β-Oxidation Enhances Metastasis and Proliferation in Endometrial Cancer.
  3. ACSL1: A preliminary study that provides a new target for the treatment of renal fibrosis could bring new insights in diabetic kidney disease.
    Title: ACSL1: A preliminary study that provides a new target for the treatment of renal fibrosis could bring new insights in diabetic kidney disease.
  4. Fatty acids and inflammatory stimuli induce expression of long-chain acyl-CoA synthetase 1 to promote lipid remodeling in diabetic kidney disease.
    Title: Fatty acids and inflammatory stimuli induce expression of long-chain acyl-CoA synthetase 1 to promote lipid remodeling in diabetic kidney disease.
  5. RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
    Title: RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
  6. Identification of toll-like receptor 5 and acyl-CoA synthetase long chain family member 1 as hub genes are correlated with the severe forms of COVID-19 by Weighted gene co-expression network analysis.
    Title: Identification of toll-like receptor 5 and acyl-CoA synthetase long chain family member 1 as hub genes are correlated with the severe forms of COVID-19 by Weighted gene co-expression network analysis.
  7. FATP2 regulates non-small cell lung cancer by mediating lipid metabolism through ACSL1.
    Title: FATP2 regulates non-small cell lung cancer by mediating lipid metabolism through ACSL1.
  8. Common genetic basis of ALS patients and soccer players may contribute to disease risk.
    Title: Common genetic basis of ALS patients and soccer players may contribute to disease risk.
  9. Circular RNA circACSL1 aggravated myocardial inflammation and myocardial injury by sponging miR-8055 and regulating MAPK14 expression.
    Title: Circular RNA circACSL1 aggravated myocardial inflammation and myocardial injury by sponging miR-8055 and regulating MAPK14 expression.
  10. Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation.
    Title: Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oleoyl-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables oleoyl-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables palmitoyl-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables phytanate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables phytanate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables pristanate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adiponectin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid import into cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid import into cell IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid import into cell ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in positive regulation of cold-induced thermogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of long-chain fatty acid import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of long-chain fatty acid import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oleic acid IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in very long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
long-chain-fatty-acid--CoA ligase 1
Names
LACS 1
LACS 2
acyl-CoA synthetase 1
arachidonate--CoA ligase
fatty-acid-Coenzyme A ligase, long-chain 1
fatty-acid-Coenzyme A ligase, long-chain 2
lignoceroyl-CoA synthase
long-chain acyl-CoA synthetase 1
long-chain acyl-CoA synthetase 2
long-chain fatty acid-CoA ligase 2
long-chain fatty-acid-coenzyme A ligase 1
palmitoyl-CoA ligase 1
palmitoyl-CoA ligase 2
paltimoyl-CoA ligase 1
phytanate--CoA ligase
NP_001273637.1
NP_001273639.1
NP_001273640.1
NP_001368806.1
NP_001368807.1
NP_001368808.1
NP_001368809.1
NP_001368810.1
NP_001368811.1
NP_001368812.1
NP_001368813.1
NP_001368814.1
NP_001368815.1
NP_001368816.1
NP_001368817.1
NP_001368818.1
NP_001368819.1
NP_001986.2
XP_016863376.1
XP_047305775.1
XP_054205230.1
XP_054205231.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286708.2 → NP_001273637.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    See identical proteins and their annotated locations for NP_001273637.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 6-12 all encode the same isoform (a).
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS3839.1
    UniProtKB/Swiss-Prot
    B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000425006.1, ENST00000504342.5
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. NM_001286710.2 → NP_001273639.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    See identical proteins and their annotated locations for NP_001273639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has an alternate in-frame exon in place of another in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini and is the same length but has an alternate internal segment compared to isoform a. Variants 3 and 13-16 all encode the same isoform (b).
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS68826.1
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000426150.1, ENST00000513317.5
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  3. NM_001286711.2 → NP_001273640.1  long-chain-fatty-acid--CoA ligase 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS68825.1
    UniProtKB/TrEMBL
    B4E0R0, E7EPM6, E7EQJ5
    Related
    ENSP00000426244.1, ENST00000507295.5
    Conserved Domains (2) summary
    PLN02736
    Location:86 → 662
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:116 → 659
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  4. NM_001381877.1 → NP_001368806.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, and 7-12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS3839.1
    UniProtKB/Swiss-Prot
    B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000534750.1, ENST00000864691.1
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  5. NM_001381878.1 → NP_001368807.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 2, 6, and 8-12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS3839.1
    UniProtKB/Swiss-Prot
    B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000534762.1, ENST00000864703.1
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  6. NM_001381879.1 → NP_001368808.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 2, 6, 7, and 9-12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS3839.1
    UniProtKB/Swiss-Prot
    B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000516352.1, ENST00000706367.1
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  7. NM_001381880.1 → NP_001368809.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 1, 2, 6-8, and 10-12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS3839.1
    UniProtKB/Swiss-Prot
    B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000534771.1, ENST00000864712.1
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  8. NM_001381881.1 → NP_001368810.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 2, 6-9, 11, and 12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS3839.1
    UniProtKB/Swiss-Prot
    B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000534775.1, ENST00000864716.1
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  9. NM_001381882.1 → NP_001368811.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1, 2, 6-10, and 12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS3839.1
    UniProtKB/Swiss-Prot
    B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000534778.1, ENST00000864719.1
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  10. NM_001381883.1 → NP_001368812.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 1, 2, and 6-11, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS3839.1
    UniProtKB/Swiss-Prot
    B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000534782.1, ENST00000864723.1
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  11. NM_001381884.1 → NP_001368813.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 3 and 14-16, encodes isoform b.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS68826.1
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000516351.1, ENST00000706366.1
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  12. NM_001381885.1 → NP_001368814.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 3, 13, 15, and 16, encodes isoform b.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS68826.1
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000534766.1, ENST00000864707.1
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  13. NM_001381886.1 → NP_001368815.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 3, 13, 14, and 16, encodes isoform b.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS68826.1
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000516353.1, ENST00000706368.1
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  14. NM_001381887.1 → NP_001368816.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 3 and 13-15, encodes isoform b.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS68826.1
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000534790.1, ENST00000864731.1
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  15. NM_001381888.1 → NP_001368817.1  long-chain-fatty-acid--CoA ligase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 18, encodes isoform e.
    Source sequence(s)
    AC079257, AC084871
    UniProtKB/TrEMBL
    B7Z3Z9
    Conserved Domains (1) summary
    cd05927
    Location:67 → 645
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  16. NM_001381889.1 → NP_001368818.1  long-chain-fatty-acid--CoA ligase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 17, encodes isoform e.
    Source sequence(s)
    AC079257, AC084871
    UniProtKB/TrEMBL
    B7Z3Z9
    Conserved Domains (1) summary
    cd05927
    Location:67 → 645
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  17. NM_001381890.1 → NP_001368819.1  long-chain-fatty-acid--CoA ligase 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
    UniProtKB/TrEMBL
    A8K9T3
    Conserved Domains (1) summary
    cd05927
    Location:52 → 630
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  18. NM_001995.5 → NP_001986.2  long-chain-fatty-acid--CoA ligase 1 isoform a

    See identical proteins and their annotated locations for NP_001986.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 6-12 all encode the same isoform (a).
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS3839.1
    UniProtKB/Swiss-Prot
    B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000281455.2, ENST00000281455.7
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RNA

  1. NR_167698.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871

  2. NR_167702.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871

  3. NR_167703.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
    Related
    ENST00000454703.6

  4. NR_167704.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871

  5. NR_167705.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871

  6. NR_167706.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871

  7. NR_167708.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871

  8. NR_167709.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
    Related
    ENST00000864730.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    184755595..184826594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007887.2 → XP_016863376.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

    UniProtKB/Swiss-Prot
    B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000422607.1, ENST00000515030.5
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. XM_047449819.1 → XP_047305775.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000534767.1, ENST00000864708.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    188099036..188170021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349256.1 → XP_054205231.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

    UniProtKB/Swiss-Prot
    B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
    UniProtKB/TrEMBL
    A8K9T3

  2. XM_054349255.1 → XP_054205230.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    UniProtKB/TrEMBL
    A8K9T3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001286712.1: Suppressed sequence

    Description
    NM_001286712.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33121.1 GenPept UniProtKB/Swiss-Prot:P33121

Gene LinkOut

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