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ACSL1 acyl-CoA synthetase long chain family member 1 [ Homo sapiens (human) ]

Gene ID: 2180, updated on 4-Jun-2020

Summary

Official Symbol
ACSL1provided by HGNC
Official Full Name
acyl-CoA synthetase long chain family member 1provided by HGNC
Primary source
HGNC:HGNC:3569
See related
Ensembl:ENSG00000151726 MIM:152425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACS1; LACS; FACL1; FACL2; LACS1; LACS2
Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Expression
Biased expression in fat (RPKM 357.3), liver (RPKM 217.4) and 10 other tissues See more
Orthologs

Genomic context

See ACSL1 in Genome Data Viewer
Location:
4q35.1
Exon count:
31
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (184755595..184826593, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (185676749..185747215, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene caspase 3 Neighboring gene primase and DNA directed polymerase Neighboring gene centromere protein U Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 pseudogene Neighboring gene uncharacterized LOC105377587 Neighboring gene MIR3945 host gene Neighboring gene microRNA 3945

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
acyl-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
arachidonate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
decanoate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
phytanate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
adiponectin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
alpha-linolenic acid metabolic process TAS
Traceable Author Statement
more info
 
linoleic acid metabolic process TAS
Traceable Author Statement
more info
 
lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid import IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
response to oleic acid IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
xenobiotic catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
long-chain-fatty-acid--CoA ligase 1
Names
LACS 1
LACS 2
acyl-CoA synthetase 1
arachidonate--CoA ligase
fatty-acid-Coenzyme A ligase, long-chain 1
fatty-acid-Coenzyme A ligase, long-chain 2
lignoceroyl-CoA synthase
long-chain acyl-CoA synthetase 1
long-chain acyl-CoA synthetase 2
long-chain fatty acid-CoA ligase 2
long-chain fatty-acid-coenzyme A ligase 1
palmitoyl-CoA ligase 1
palmitoyl-CoA ligase 2
paltimoyl-CoA ligase 1
phytanate--CoA ligase
NP_001273637.1
NP_001273639.1
NP_001273640.1
NP_001368806.1
NP_001368807.1
NP_001368808.1
NP_001368809.1
NP_001368810.1
NP_001368811.1
NP_001368812.1
NP_001368813.1
NP_001368814.1
NP_001368815.1
NP_001368816.1
NP_001368817.1
NP_001368818.1
NP_001368819.1
NP_001986.2
XP_016863376.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286708.2NP_001273637.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    See identical proteins and their annotated locations for NP_001273637.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 6-12 all encode the same isoform (a).
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS3839.1
    UniProtKB/Swiss-Prot
    P33121
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000425006.1, ENST00000504342.5
    Conserved Domains (2) summary
    PLN02736
    Location:86696
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:116693
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  2. NM_001286710.2NP_001273639.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    See identical proteins and their annotated locations for NP_001273639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has an alternate in-frame exon in place of another in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini and is the same length but has an alternate internal segment compared to isoform a. Variants 3 and 13-16 all encode the same isoform (b).
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS68826.1
    UniProtKB/Swiss-Prot
    P33121
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000426150.1, ENST00000513317.5
    Conserved Domains (2) summary
    PLN02736
    Location:86696
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:116693
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  3. NM_001286711.2NP_001273640.1  long-chain-fatty-acid--CoA ligase 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS68825.1
    UniProtKB/Swiss-Prot
    P33121
    UniProtKB/TrEMBL
    A8K9T3, B4E0R0, E7EPM6
    Related
    ENSP00000426244.1, ENST00000507295.5
    Conserved Domains (2) summary
    PLN02736
    Location:86662
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:116659
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  4. NM_001381877.1NP_001368806.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, and 7-12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
  5. NM_001381878.1NP_001368807.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 2, 6, and 8-12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
  6. NM_001381879.1NP_001368808.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 2, 6, 7, and 9-12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
  7. NM_001381880.1NP_001368809.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 1, 2, 6-8, and 10-12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
  8. NM_001381881.1NP_001368810.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 2, 6-9, 11, and 12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
  9. NM_001381882.1NP_001368811.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1, 2, 6-10, and 12, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
  10. NM_001381883.1NP_001368812.1  long-chain-fatty-acid--CoA ligase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 1, 2, and 6-11, encodes isoform a.
    Source sequence(s)
    AC079257, AC084871
  11. NM_001381884.1NP_001368813.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 3 and 14-16, encodes isoform b.
    Source sequence(s)
    AC079257, AC084871
  12. NM_001381885.1NP_001368814.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 3, 13, 15, and 16, encodes isoform b.
    Source sequence(s)
    AC079257, AC084871
  13. NM_001381886.1NP_001368815.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 3, 13, 14, and 16, encodes isoform b.
    Source sequence(s)
    AC079257, AC084871
  14. NM_001381887.1NP_001368816.1  long-chain-fatty-acid--CoA ligase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 3 and 13-15, encodes isoform b.
    Source sequence(s)
    AC079257, AC084871
  15. NM_001381888.1NP_001368817.1  long-chain-fatty-acid--CoA ligase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 18, encodes isoform e.
    Source sequence(s)
    AC079257, AC084871
  16. NM_001381889.1NP_001368818.1  long-chain-fatty-acid--CoA ligase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 17, encodes isoform e.
    Source sequence(s)
    AC079257, AC084871
  17. NM_001381890.1NP_001368819.1  long-chain-fatty-acid--CoA ligase 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  18. NM_001995.5NP_001986.2  long-chain-fatty-acid--CoA ligase 1 isoform a

    See identical proteins and their annotated locations for NP_001986.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 6-12 all encode the same isoform (a).
    Source sequence(s)
    AC079257, AC084871
    Consensus CDS
    CCDS3839.1
    UniProtKB/Swiss-Prot
    P33121
    UniProtKB/TrEMBL
    A8K9T3
    Related
    ENSP00000281455.2, ENST00000281455.7
    Conserved Domains (2) summary
    PLN02736
    Location:86696
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:116693
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RNA

  1. NR_167698.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  2. NR_167702.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  3. NR_167703.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  4. NR_167704.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  5. NR_167705.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  6. NR_167706.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  7. NR_167708.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871
  8. NR_167709.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079257, AC084871

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    184755595..184826593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007887.1XP_016863376.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    UniProtKB/Swiss-Prot
    P33121
    Related
    ENSP00000422607.1, ENST00000515030.5
    Conserved Domains (2) summary
    PLN02736
    Location:86696
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:116693
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001286712.1: Suppressed sequence

    Description
    NM_001286712.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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