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BPIFA2 BPI fold containing family A member 2 [ Homo sapiens (human) ]

Gene ID: 140683, updated on 7-Jun-2020

Summary

Official Symbol
BPIFA2provided by HGNC
Official Full Name
BPI fold containing family A member 2provided by HGNC
Primary source
HGNC:HGNC:16203
See related
Ensembl:ENSG00000131050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSP; SPLUNC2; C20orf70; bA49G10.1
Summary
This gene encodes a member of the palate, lung and nasal epithelium clone (Plunc) family of proteins. Members of this family have been proposed to play a role in the local antibacterial response in nose, mouth and upper respiratory pathways. The encoded soluble salivary protein binds bacterial lipopolysaccharide (LPS) and inhibits bacterial growth. This gene is present in a gene cluster on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Restricted expression toward salivary gland (RPKM 1129.7) See more
Orthologs

Genomic context

See BPIFA2 in Genome Data Viewer
Location:
20q11.21
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (33161770..33181412)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31749660..31769223)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene BPI fold containing family B member 4 Neighboring gene uncharacterized LOC105372714 Neighboring gene suppressor of cytokine signaling 2 pseudogene 1 Neighboring gene BPI fold containing family A member 4, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antimicrobial humoral response TAS
Traceable Author Statement
more info
 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
BPI fold-containing family A member 2
Names
parotid secretory protein
short palate, lung and nasal epithelium carcinoma-associated protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319164.2NP_001306093.1  BPI fold-containing family A member 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL121901, AY359055
    Consensus CDS
    CCDS13214.1
    UniProtKB/Swiss-Prot
    Q96DR5
    Related
    ENSP00000253362.2, ENST00000253362.6
    Conserved Domains (1) summary
    pfam01273
    Location:62227
    LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain
  2. NM_080574.4NP_542141.1  BPI fold-containing family A member 2 precursor

    See identical proteins and their annotated locations for NP_542141.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC065726
    Consensus CDS
    CCDS13214.1
    UniProtKB/Swiss-Prot
    Q96DR5
    UniProtKB/TrEMBL
    A8K739
    Related
    ENSP00000347012.5, ENST00000354932.6
    Conserved Domains (1) summary
    pfam01273
    Location:62227
    LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    33161770..33181412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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