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F10 coagulation factor X [ Mus musculus (house mouse) ]

Gene ID: 14058, updated on 28-Aug-2018

Summary

Official Symbol
F10provided by MGI
Official Full Name
coagulation factor Xprovided by MGI
Primary source
MGI:MGI:103107
See related
Ensembl:ENSMUSG00000031444 Vega:OTTMUSG00000020614
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
fX; Cf10
Summary
This gene encodes factor X, a component of both the intrinsic and extrinsic blood coagulation pathways. The encoded protein is a zymogen that undergoes further processing in a vitamin K-dependent manner to generate mature factor X, a heterodimer comprised of disulfide-linked heavy and light chains. The mature factor X is proteolytically activated either by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway) to form factor Xa serine endopeptidase. Activated factor Xa catalyzes the conversion of prothrombin to thrombin. A complete lack of the encoded protein is fatal to mice. A severe deficiency of the encoded protein in mice causes age-dependent iron deposition and cardiac fibrosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Expression
Biased expression in liver E18 (RPKM 103.5), liver adult (RPKM 83.2) and 3 other tissues See more
Orthologs

Genomic context

See F10 in Genome Data Viewer
Location:
8 A1.1; 8 5.73 cM
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (13037308..13056676)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (13037308..13056216)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene CD24a antigen pseudogene Neighboring gene coagulation factor VII Neighboring gene protein Z, vitamin K-dependent plasma glycoprotein Neighboring gene predicted gene, 33691 Neighboring gene predicted gene 17023 Neighboring gene PCI domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blood coagulation ISO
Inferred from Sequence Orthology
more info
 
hemostasis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
coagulation factor X
Names
stuart factor
NP_001229297.1
NP_031998.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242368.1NP_001229297.1  coagulation factor X isoform 1

    See identical proteins and their annotated locations for NP_001229297.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC127308, BC050219
    Consensus CDS
    CCDS57606.1
    UniProtKB/TrEMBL
    Q3U3V1, Q80Y26
    Related
    ENSMUSP00000033821.4, OTTMUSP00000022500, ENSMUST00000033821.10, OTTMUST00000048845
    Conserved Domains (5) summary
    smart00020
    Location:243471
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:3697
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:98134
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:244473
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:141176
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. NM_007972.4NP_031998.3  coagulation factor X isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_031998.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC127308, AF087644
    Consensus CDS
    CCDS40226.1
    UniProtKB/Swiss-Prot
    O88947
    UniProtKB/TrEMBL
    Q3TBR2
    Related
    ENSMUSP00000068389.5, OTTMUSP00000022499, ENSMUST00000063820.11, OTTMUST00000048844
    Conserved Domains (5) summary
    smart00020
    Location:231459
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:2485
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:86122
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:232461
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:129164
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    13037308..13056676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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