Format

Send to:

Choose Destination

ADORA3 adenosine A3 receptor [ Homo sapiens (human) ]

Gene ID: 140, updated on 17-Jun-2019

Summary

Official Symbol
ADORA3provided by HGNC
Official Full Name
adenosine A3 receptorprovided by HGNC
Primary source
HGNC:HGNC:268
See related
Ensembl:ENSG00000282608 MIM:600445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A3AR
Summary
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
Expression
Broad expression in adrenal (RPKM 4.4), small intestine (RPKM 2.9) and 20 other tissues See more
Orthologs

Genomic context

See ADORA3 in Genome Data Viewer
Location:
1p13.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (111499429..111504121, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (112025970..112106602, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATP synthase peripheral stalk-membrane subunit b Neighboring gene chromosome 1 open reading frame 162 Neighboring gene RNA, U6 small nuclear 792, pseudogene Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene long intergenic non-protein coding RNA 1160 Neighboring gene uncharacterized LOC107985184 Neighboring gene Sharpr-MPRA regulatory region 155

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of adenosine A3 receptor (ADORA3) in peptide-treated PBMCs PubMed
Tat tat HIV-1 Tat upregulates adenosine A3 receptor in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adenosine P1 receptors, organism-specific biosystem (from REACTOME)
    Adenosine P1 receptors, organism-specific biosystemThe adenosine receptors (P1 receptors) are a class of purinergic receptors, G-protein coupled receptors with adenosine as their endogenous ligand.In humans, there are four adenosine receptors. Each i...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Nucleotide GPCRs, organism-specific biosystem (from WikiPathways)
    Nucleotide GPCRs, organism-specific biosystem
    Nucleotide GPCRs
  • Nucleotide-like (purinergic) receptors, organism-specific biosystem (from REACTOME)
    Nucleotide-like (purinergic) receptors, organism-specific biosystemPurinergic receptors (Burnstock G, 2006; Abbracchio MP et al, 2009) are a family of newly characterized plasma membrane molecules involved in several cellular functions such as vascular reactivity, a...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
    Sphingolipid signaling pathway, organism-specific biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • Sphingolipid signaling pathway, conserved biosystem (from KEGG)
    Sphingolipid signaling pathway, conserved biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled adenosine receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
adenosine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart contraction TAS
Traceable Author Statement
more info
PubMed 
response to wounding TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032119.1 RefSeqGene

    Range
    5001..85628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_424

mRNA and Protein(s)

  1. NM_000677.3NP_000668.1  adenosine receptor A3 isoform A

    See identical proteins and their annotated locations for NP_000668.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) encodes the longest isoform (A).
    Source sequence(s)
    AL390195, BC029831, BM675096
    Consensus CDS
    CCDS839.1
    UniProtKB/Swiss-Prot
    P0DMS8
    Related
    ENSP00000241356.4, ENST00000241356.4
    Conserved Domains (2) summary
    cd14964
    Location:1539
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:13293
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001302678.2NP_001289607.1  adenosine receptor A3 isoform B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) uses an alternate splice site in the 3' terminal exon, resulting in an alternate 3' coding region and 3' UTR, compared to variant A. The encoded isoform (B) has a distinct C-terminus and is shorter than isoform A.
    Source sequence(s)
    AL390195, BF432324, BM675096, CD013875, JN855714
    Consensus CDS
    CCDS81358.1
    UniProtKB/TrEMBL
    A0A0J9YWR0, H6VQ59
    Related
    ENSP00000488073.1, ENST00000632535.1
    Conserved Domains (1) summary
    cl21561
    Location:21109
    7tm_4; Olfactory receptor
  3. NM_001302679.2NP_001289608.1  adenosine receptor A3 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) uses an alternate splice site in the 5' terminal exon, and it thus differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant A. The encoded isoform (C) is shorter at the N-terminus, compared to isoform A.
    Source sequence(s)
    AL390195, BF432324, BM675096, BX283401, JN855714
    UniProtKB/TrEMBL
    H6VQ59
    Conserved Domains (1) summary
    pfam00001
    Location:1137
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    111499429..111504121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center