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ADORA3 adenosine A3 receptor [ Homo sapiens (human) ]

Gene ID: 140, updated on 6-May-2021

Summary

Official Symbol
ADORA3provided by HGNC
Official Full Name
adenosine A3 receptorprovided by HGNC
Primary source
HGNC:HGNC:268
See related
Ensembl:ENSG00000282608 MIM:600445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A3AR
Summary
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
Expression
Broad expression in adrenal (RPKM 4.4), small intestine (RPKM 2.9) and 20 other tissues See more
Orthologs
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Genomic context

See ADORA3 in Genome Data Viewer
Location:
1p13.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (111499429..111503633, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (112042051..112046255, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATP synthase peripheral stalk-membrane subunit b Neighboring gene chromosome 1 open reading frame 162 Neighboring gene RNA, U6 small nuclear 792, pseudogene Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene long intergenic non-protein coding RNA 1160 Neighboring gene uncharacterized LOC107985184 Neighboring gene Sharpr-MPRA regulatory region 155

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of adenosine A3 receptor (ADORA3) in peptide-treated PBMCs PubMed
Tat tat HIV-1 Tat upregulates adenosine A3 receptor in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032119.1 RefSeqGene

    Range
    5001..85628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_424

mRNA and Protein(s)

  1. NM_000677.4NP_000668.1  adenosine receptor A3 isoform A

    See identical proteins and their annotated locations for NP_000668.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) encodes the longest isoform (A).
    Source sequence(s)
    AL390195, BC029831, BM675096
    Consensus CDS
    CCDS839.1
    UniProtKB/Swiss-Prot
    P0DMS8
    Related
    ENSP00000241356.4, ENST00000241356.5
    Conserved Domains (2) summary
    cd14964
    Location:1539
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:13293
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001302678.2NP_001289607.1  adenosine receptor A3 isoform B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) uses an alternate splice site in the 3' terminal exon, resulting in an alternate 3' coding region and 3' UTR, compared to variant A. The encoded isoform (B) has a distinct C-terminus and is shorter than isoform A.
    Source sequence(s)
    AL390195, BF432324, BM675096, CD013875, JN855714
    Consensus CDS
    CCDS81358.1
    UniProtKB/TrEMBL
    A0A0J9YWR0, H6VQ59
    Related
    ENSP00000488073.1, ENST00000632535.1
    Conserved Domains (2) summary
    cd14964
    Location:1440
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:13116
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. NM_001302679.2NP_001289608.1  adenosine receptor A3 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) uses an alternate splice site in the 5' terminal exon, and it thus differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant A. The encoded isoform (C) is shorter at the N-terminus, compared to isoform A.
    Source sequence(s)
    AL390195, BF432324, BM675096, BX283401, JN855714
    UniProtKB/TrEMBL
    H6VQ59
    Conserved Domains (2) summary
    cd14964
    Location:2959
    7tm_GPCRs; TM helix 5 [structural motif]
    cl28897
    Location:1148
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    111499429..111503633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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