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CRKL CRK like proto-oncogene, adaptor protein [ Homo sapiens (human) ]

Gene ID: 1399, updated on 11-Jun-2025
Official Symbol
CRKLprovided by HGNC
Official Full Name
CRK like proto-oncogene, adaptor proteinprovided by HGNC
Primary source
HGNC:HGNC:2363
See related
Ensembl:ENSG00000099942 MIM:602007; AllianceGenome:HGNC:2363
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
Expression
Ubiquitous expression in brain (RPKM 22.4), bone marrow (RPKM 22.0) and 25 other tissues See more
Orthologs
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See CRKL in Genome Data Viewer
Location:
22q11.21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20917407..20953747)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (21326128..21362450)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21271695..21308035)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase alpha Neighboring gene Sharpr-MPRA regulatory region 10582 Neighboring gene serpin family D member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13500 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:21213217-21214026 Neighboring gene Sharpr-MPRA regulatory region 10319 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:21227050-21227239 Neighboring gene MPRA-validated peak4460 silencer Neighboring gene synaptosome associated protein 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:21240059-21240559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18689 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:21278919-21279566 Neighboring gene uncharacterized LOC124905167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:21305807-21306308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:21306309-21306808 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:21310951-21311146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:21311117-21311712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18691 Neighboring gene long intergenic non-protein coding RNA 1637 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:21326197-21326388 Neighboring gene Sharpr-MPRA regulatory region 818 Neighboring gene AIF family member 3

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2020-04-13)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2020-04-13)

ClinGen Genome Curation PagePubMed
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cadherin binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in JNK cascade TAS
Traceable Author Statement
more info
PubMed 
involved_in Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within acetylcholine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within blood vessel development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to interleukin-7 IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to transforming growth factor beta stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cerebellar neuron development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chordate pharynx development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cranial skeletal system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within dendrite development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endothelin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in enzyme-linked receptor protein signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in enzyme-linked receptor protein signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within heart development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within helper T cell diapedesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hippocampus development IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within male gonad development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron migration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within parathyroid gland development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pattern specification process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic specialization assembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within reelin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of T cell migration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of skeletal muscle acetylcholine-gated channel clustering IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to fibroblast growth factor IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within single fertilization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within thymus development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within urogenital system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in extrinsic component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
crk-like protein
Names
v-crk avian sarcoma virus CT10 oncogene homolog-like

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016354.1 RefSeqGene

    Range
    4982..41322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005207.4NP_005198.1  crk-like protein

    See identical proteins and their annotated locations for NP_005198.1

    Status: REVIEWED

    Source sequence(s)
    AA844269, AC002470, BC043500, X59656
    Consensus CDS
    CCDS13785.1
    UniProtKB/Swiss-Prot
    A8KA44, D3DX35, P46109
    Related
    ENSP00000346300.3, ENST00000354336.8
    Conserved Domains (3) summary
    cd09926
    Location:6106
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:126180
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    cd11759
    Location:237293
    SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

RNA

  1. NR_156180.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA844269, AC002470

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    20917407..20953747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    21326128..21362450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)