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CRKL CRK like proto-oncogene, adaptor protein [ Homo sapiens (human) ]

Gene ID: 1399, updated on 4-Oct-2020

Summary

Official Symbol
CRKLprovided by HGNC
Official Full Name
CRK like proto-oncogene, adaptor proteinprovided by HGNC
Primary source
HGNC:HGNC:2363
See related
Ensembl:ENSG00000099942 MIM:602007
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
Expression
Ubiquitous expression in brain (RPKM 22.4), bone marrow (RPKM 22.0) and 25 other tissues See more
Orthologs

Genomic context

See CRKL in Genome Data Viewer
Location:
22q11.21
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (20917407..20953747)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21271714..21308037)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase alpha Neighboring gene serpin family D member 1 Neighboring gene synaptosome associated protein 29 Neighboring gene long intergenic non-protein coding RNA 1637 Neighboring gene Sharpr-MPRA regulatory region 818 Neighboring gene apoptosis inducing factor mitochondria associated 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2020-04-13)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated (2020-04-13)

ClinGen Genome Curation PagePubMed

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
JNK cascade TAS
Traceable Author Statement
more info
PubMed 
Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acetylcholine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
activation of MAPKK activity TAS
Traceable Author Statement
more info
 
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
blood vessel development IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-7 IEA
Inferred from Electronic Annotation
more info
 
cellular response to transforming growth factor beta stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellar neuron development IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
cranial skeletal system development IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
dendrite development IEA
Inferred from Electronic Annotation
more info
 
endothelin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
helper T cell diapedesis IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
parathyroid gland development IEA
Inferred from Electronic Annotation
more info
 
pharynx development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Ras protein signal transduction TAS
Traceable Author Statement
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
reelin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of T cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
 
regulation of skeletal muscle acetylcholine-gated channel clustering IEA
Inferred from Electronic Annotation
more info
 
retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
single fertilization IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
synapse assembly IEA
Inferred from Electronic Annotation
more info
 
thymus development IEA
Inferred from Electronic Annotation
more info
 
urogenital system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extrinsic component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
crk-like protein
Names
v-crk avian sarcoma virus CT10 oncogene homolog-like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016354.1 RefSeqGene

    Range
    4982..41322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005207.4NP_005198.1  crk-like protein

    See identical proteins and their annotated locations for NP_005198.1

    Status: REVIEWED

    Source sequence(s)
    AA844269, AC002470, BC043500, X59656
    Consensus CDS
    CCDS13785.1
    UniProtKB/Swiss-Prot
    P46109
    Related
    ENSP00000346300.3, ENST00000354336.8
    Conserved Domains (3) summary
    cd09926
    Location:6106
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:126180
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    cd11759
    Location:237293
    SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

RNA

  1. NR_156180.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA844269, AC002470

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    20917407..20953747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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