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DOCK11 dedicator of cytokinesis 11 [ Homo sapiens (human) ]

Gene ID: 139818, updated on 2-Mar-2021

Summary

Official Symbol
DOCK11provided by HGNC
Official Full Name
dedicator of cytokinesis 11provided by HGNC
Primary source
HGNC:HGNC:23483
See related
Ensembl:ENSG00000147251 MIM:300681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACG; ZIZ2; bB128O4.1
Expression
Broad expression in fat (RPKM 20.0), lymph node (RPKM 11.7) and 19 other tissues See more
Orthologs
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Genomic context

See DOCK11 in Genome Data Viewer
Location:
Xq24
Exon count:
57
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (118495664..118686153)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (117629778..117820110)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene 43 Neighboring gene WD repeat domain 44 Neighboring gene microRNA 1277 Neighboring gene RBBP8 pseudogene 1 Neighboring gene interleukin 13 receptor subunit alpha 1 Neighboring gene TMEM30B pseudogene 1 Neighboring gene zinc finger CCHC-type containing 12

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32122, FLJ43653

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
marginal zone B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
dedicator of cytokinesis protein 11
Names
Activated Cdc42-associated guanine nucleotide exchange factor, ACG
zizimin-2
zizimin2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144658.4NP_653259.3  dedicator of cytokinesis protein 11

    See identical proteins and their annotated locations for NP_653259.3

    Status: VALIDATED

    Source sequence(s)
    AC007021, AK124735, AY692226
    Consensus CDS
    CCDS35373.1
    UniProtKB/Swiss-Prot
    Q5JSL3
    Related
    ENSP00000276202.7, ENST00000276202.8
    Conserved Domains (5) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11700
    Location:16152027
    DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
    cd13267
    Location:161284
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:166271
    PH; PH domain
    pfam11878
    Location:54145
    DUF3398; Domain of unknown function (DUF3398)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    118495664..118686153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262368.4XP_005262425.1  dedicator of cytokinesis protein 11 isoform X1

    Conserved Domains (5) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11700
    Location:16282040
    DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
    cd13267
    Location:161284
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:166271
    PH; PH domain
    pfam11878
    Location:54145
    DUF3398; Domain of unknown function (DUF3398)
  2. XM_011531276.3XP_011529578.1  dedicator of cytokinesis protein 11 isoform X2

    Conserved Domains (5) summary
    cd08697
    Location:615804
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11700
    Location:16042016
    DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
    cd13267
    Location:137260
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:142247
    PH; PH domain
    pfam11878
    Location:30121
    DUF3398; Domain of unknown function (DUF3398)
  3. XM_005262369.5XP_005262426.1  dedicator of cytokinesis protein 11 isoform X3

    Related
    ENSP00000487829.1, ENST00000633080.1
    Conserved Domains (5) summary
    cd08697
    Location:608797
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11700
    Location:15972009
    DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
    cd13267
    Location:130253
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:135240
    PH; PH domain
    pfam11878
    Location:23114
    DUF3398; Domain of unknown function (DUF3398)
  4. XM_011531278.3XP_011529580.1  dedicator of cytokinesis protein 11 isoform X4

    Conserved Domains (2) summary
    cd08697
    Location:11200
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11700
    Location:10001412
    DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
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