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Dock11 dedicator of cytokinesis 11 [ Mus musculus (house mouse) ]

Gene ID: 75974, updated on 26-Sep-2022

Summary

Official Symbol
Dock11provided by MGI
Official Full Name
dedicator of cytokinesis 11provided by MGI
Primary source
MGI:MGI:1923224
See related
Ensembl:ENSMUSG00000031093 AllianceGenome:MGI:1923224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sph238; Zizimin2; 8030476J24; 5033414A21Rik
Summary
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including marginal zone B cell differentiation; positive regulation of GTPase activity; and positive regulation of filopodium assembly. Is expressed in brain; female reproductive system; gut; skin; and spleen. Orthologous to human DOCK11 (dedicator of cytokinesis 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 4.2), CNS E14 (RPKM 3.9) and 22 other tissues See more
Orthologs
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Genomic context

See Dock11 in Genome Data Viewer
Location:
X; X A3.3
Exon count:
57
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (35150924..35340223)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (35887271..36076570)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene WD repeat domain 44 pseudogene Neighboring gene predicted gene, 25624 Neighboring gene interleukin 13 receptor, alpha 1 Neighboring gene predicted gene, 42406 Neighboring gene zinc finger, CCHC domain containing 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
dedicator of cytokinesis protein 11
Names
ACG
activated Cdc42-associated guanine nucleotide exchange factor
spleen specific 238 kDa protein with PH domain
zizimin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009947.3NP_001009947.2  dedicator of cytokinesis protein 11

    See identical proteins and their annotated locations for NP_001009947.2

    Status: VALIDATED

    Source sequence(s)
    AL672023, AL672038
    Consensus CDS
    CCDS40923.1
    UniProtKB/Swiss-Prot
    A2AF47, Q5KTP7
    Related
    ENSMUSP00000033419.6, ENSMUST00000033419.13
    Conserved Domains (5) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11700
    Location:16152027
    DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
    cd13267
    Location:161283
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:166271
    PH; PH domain
    pfam11878
    Location:54145
    DUF3398; Domain of unknown function (DUF3398)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    35150924..35340223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541408.4XP_006541471.1  dedicator of cytokinesis protein 11 isoform X3

    Conserved Domains (4) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11700
    Location:16282040
    DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
    cd13267
    Location:161283
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:37147
    DUF3398; Domain of unknown function (DUF3398)
  2. XM_006541406.4XP_006541469.1  dedicator of cytokinesis protein 11 isoform X1

    Conserved Domains (4) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11700
    Location:16282040
    DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
    cd13267
    Location:161283
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:37147
    DUF3398; Domain of unknown function (DUF3398)
  3. XM_006541407.5XP_006541470.1  dedicator of cytokinesis protein 11 isoform X2

    Conserved Domains (4) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11700
    Location:16162028
    DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11
    cd13267
    Location:161283
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:37147
    DUF3398; Domain of unknown function (DUF3398)
  4. XM_036162113.1XP_036018006.1  dedicator of cytokinesis protein 11 isoform X4

    Conserved Domains (4) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:161283
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:38147
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:15621747
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
  5. XM_036162114.1XP_036018007.1  dedicator of cytokinesis protein 11 isoform X5

    Conserved Domains (3) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:161283
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:38147
    DUF3398; Domain of unknown function (DUF3398)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177745.2: Suppressed sequence

    Description
    NM_177745.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.