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PNCK pregnancy up-regulated nonubiquitous CaM kinase [ Homo sapiens (human) ]

Gene ID: 139728, updated on 26-Oct-2022

Summary

Official Symbol
PNCKprovided by HGNC
Official Full Name
pregnancy up-regulated nonubiquitous CaM kinaseprovided by HGNC
Primary source
HGNC:HGNC:13415
See related
Ensembl:ENSG00000130822 MIM:300680; AllianceGenome:HGNC:13415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BSTK3; CaMK1b
Summary
PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in brain (RPKM 7.4), prostate (RPKM 4.6) and 11 other tissues See more
Orthologs
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Genomic context

See PNCK in Genome Data Viewer
Location:
Xq28
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (153669733..153687771, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151943398..151961436, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152935188..152953226, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18a pseudogene 16 Neighboring gene RNA, 7SL, cytoplasmic 687, pseudogene Neighboring gene solute carrier family 6 member 8 Neighboring gene B cell receptor associated protein 31 Neighboring gene Sharpr-MPRA regulatory region 5891

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ50403, FLJ50549, FLJ56451, FLJ59811, MGC45419

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type 1B
Names
caM kinase I beta
caM kinase IB
caM-KI beta
caMKI-beta
pregnancy up-regulated non-ubiquitously-expressed CaM kinase
pregnancy upregulated non-ubiquitously expressed CaM kinase
NP_001034671.3
NP_001129212.1
NP_001353904.1
NP_001353905.1
NP_001353906.1
NP_001353907.1
NP_001353908.1
NP_001353909.1
XP_011529409.2
XP_011529410.1
XP_011529413.1
XP_011529414.1
XP_016884768.1
XP_024308108.1
XP_047297792.1
XP_047297793.1
XP_047297794.1
XP_047297795.1
XP_047297796.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039582.3NP_001034671.3  calcium/calmodulin-dependent protein kinase type 1B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK296203, AK303746, CF890832, DC383841
    Consensus CDS
    CCDS35503.2
    UniProtKB/Swiss-Prot
    Q6P2M8
    Related
    ENSP00000405950.2, ENST00000447676.6
    Conserved Domains (2) summary
    smart00220
    Location:98353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14169
    Location:94370
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
  2. NM_001135740.2NP_001129212.1  calcium/calmodulin-dependent protein kinase type 1B isoform b

    See identical proteins and their annotated locations for NP_001129212.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK303746, CF890832
    Consensus CDS
    CCDS48189.1
    UniProtKB/Swiss-Prot
    Q6P2M8
    Related
    ENSP00000359164.4, ENST00000370145.8
    Conserved Domains (2) summary
    smart00220
    Location:32287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14169
    Location:28304
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
  3. NM_001366975.1NP_001353904.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 4-8, encodes isoform c.
    Source sequence(s)
    U52111
    Consensus CDS
    CCDS94698.1
    UniProtKB/Swiss-Prot
    Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
  4. NM_001366976.1NP_001353905.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 3 and 5-8, encodes isoform c.
    Source sequence(s)
    U52111
    Consensus CDS
    CCDS94698.1
    UniProtKB/Swiss-Prot
    Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
  5. NM_001366977.1NP_001353906.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 3, 6, 7, and 8, encodes isoform c.
    Source sequence(s)
    U52111
    Consensus CDS
    CCDS94698.1
    UniProtKB/Swiss-Prot
    Q8N4R0
    Related
    ENSP00000340586.4, ENST00000340888.8
    Conserved Domains (1) summary
    cd14169
    Location:11287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
  6. NM_001366978.1NP_001353907.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 3-5, 7, and 8, encodes isoform c.
    Source sequence(s)
    U52111
    Consensus CDS
    CCDS94698.1
    UniProtKB/Swiss-Prot
    Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
  7. NM_001366979.1NP_001353908.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 3-6 and 8, encodes isoform c.
    Source sequence(s)
    U52111
    Consensus CDS
    CCDS94698.1
    UniProtKB/Swiss-Prot
    Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
  8. NM_001366980.1NP_001353909.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 3-7, encodes isoform c.
    Source sequence(s)
    U52111
    Consensus CDS
    CCDS94698.1
    UniProtKB/Swiss-Prot
    Q8N4R0
    Related
    ENSP00000359169.1, ENST00000370150.5
    Conserved Domains (1) summary
    cd14169
    Location:11287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    153669733..153687771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531107.3XP_011529409.2  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    Q6P2M8, Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
  2. XM_047441836.1XP_047297792.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    Q8N4R0
  3. XM_047441838.1XP_047297794.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    Q8N4R0
  4. XM_047441837.1XP_047297793.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    Q8N4R0
    Related
    ENST00000466074.5
  5. XM_047441839.1XP_047297795.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    Q8N4R0
  6. XM_024452340.2XP_024308108.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
  7. XM_011531108.3XP_011529410.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

    See identical proteins and their annotated locations for XP_011529410.1

    Conserved Domains (2) summary
    smart00220
    Location:33288
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14169
    Location:29305
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
  8. XM_011531112.3XP_011529414.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    See identical proteins and their annotated locations for XP_011529414.1

    UniProtKB/Swiss-Prot
    Q6P2M8, Q8N4R0
    Related
    ENSP00000359161.1, ENST00000370142.5
    Conserved Domains (1) summary
    cd14169
    Location:11287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
  9. XM_011531111.3XP_011529413.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    See identical proteins and their annotated locations for XP_011529413.1

    UniProtKB/Swiss-Prot
    Q6P2M8, Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
  10. XM_017029279.2XP_016884768.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    Q6P2M8, Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta
  11. XM_047441840.1XP_047297796.1  calcium/calmodulin-dependent protein kinase type 1B isoform X3

    UniProtKB/TrEMBL
    B4DJP1
    Related
    ENST00000489536.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    151943398..151961436 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198452.1: Suppressed sequence

    Description
    NM_198452.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay candidate.