Format

Send to:

Choose Destination

CRHR2 corticotropin releasing hormone receptor 2 [ Homo sapiens (human) ]

Gene ID: 1395, updated on 1-Aug-2020

Summary

Official Symbol
CRHR2provided by HGNC
Official Full Name
corticotropin releasing hormone receptor 2provided by HGNC
Primary source
HGNC:HGNC:2358
See related
Ensembl:ENSG00000106113 MIM:602034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRF2; CRFR2; CRF-RB; HM-CRF
Summary
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See CRHR2 in Genome Data Viewer
Location:
7p14.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (30649406..30700103, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (30691559..30739719, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene GARS1 divergent transcript Neighboring gene glycyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC105375220 Neighboring gene uncharacterized LOC105375219 Neighboring gene INMT-MINDY4 readthrough (NMD candidate) Neighboring gene indolethylamine N-methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
corticotrophin-releasing factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
corticotropin-releasing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to corticotropin-releasing hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
corticotropin-releasing factor receptor 2
Names
CRF2 receptor, beta isoform
CRH receptor 2 variant B
CRH-R2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029169.1 RefSeqGene

    Range
    5001..53161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202475.1NP_001189404.1  corticotropin-releasing factor receptor 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001189404.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains additional in-frame coding exons at the 5' end compared to variant 1, resulting in an isoform (2, also known as beta isoform) with a longer and distinct N-terminus compared to isoform 1. This receptor subtype was shown to mediate urocortin-induced MAPK activation in human myometrium (PMID:11117536).
    Source sequence(s)
    AC004976, AF011406, CN367944, DB308619, U34587
    Consensus CDS
    CCDS56478.1
    UniProtKB/Swiss-Prot
    Q13324
    Related
    ENSP00000340943.4, ENST00000348438.8
    Conserved Domains (2) summary
    smart00008
    Location:63134
    HormR; Domain present in hormone receptors
    pfam00002
    Location:140382
    7tm_2; 7 transmembrane receptor (Secretin family)
  2. NM_001202481.1NP_001189410.1  corticotropin-releasing factor receptor 2 isoform 3

    See identical proteins and their annotated locations for NP_001189410.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains additional exons at the 5' end compared to variant 1, resulting in a shorter isoform (3, also known as gamma isoform) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC004976, AF011406, AF019381, CN367944, DB308619, U34587, Y10153
    Consensus CDS
    CCDS56477.1
    UniProtKB/Swiss-Prot
    Q13324
    Related
    ENSP00000344304.4, ENST00000341843.8
    Conserved Domains (2) summary
    smart00008
    Location:2293
    HormR; Domain present in hormone receptors
    pfam00002
    Location:99341
    7tm_2; 7 transmembrane receptor (Secretin family)
  3. NM_001202482.1NP_001189411.1  corticotropin-releasing factor receptor 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame acceptor splice site at one of the coding exons compared to variant 1, resulting in an isoform (4, also known as isoform desQ) 1 aa shorter than isoform 1.
    Source sequence(s)
    AC004976, AF011406, CN367944, DA808296, DB308619, EU012443, U34587
    UniProtKB/Swiss-Prot
    Q13324
    Conserved Domains (2) summary
    smart00008
    Location:36107
    HormR; Domain present in hormone receptors
    pfam00002
    Location:112354
    7tm_2; 7 transmembrane receptor (Secretin family)
  4. NM_001202483.1NP_001189412.1  corticotropin-releasing factor receptor 2 isoform 5

    See identical proteins and their annotated locations for NP_001189412.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an additional exon at the penultimate position compared to variant 1, resulting in a frame-shift and a shorter isoform (5, also known as isoform D) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC004976, AK313661, CN367944, DA808296, DB308619, EU012439, U34587
    Consensus CDS
    CCDS75576.1
    UniProtKB/Swiss-Prot
    Q13324
    Related
    ENSP00000426498.3, ENST00000506074.6
    Conserved Domains (2) summary
    smart00008
    Location:36107
    HormR; Domain present in hormone receptors
    pfam00002
    Location:113355
    7tm_2; 7 transmembrane receptor (Secretin family)
  5. NM_001883.5NP_001874.2  corticotropin-releasing factor receptor 2 isoform 1

    See identical proteins and their annotated locations for NP_001874.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as alpha isoform).
    Source sequence(s)
    AC004976, AK313661, CN367944, DA808296, DB308619, U34587
    Consensus CDS
    CCDS5429.1
    UniProtKB/Swiss-Prot
    Q13324
    UniProtKB/TrEMBL
    A0A090N7T4
    Related
    ENSP00000418722.1, ENST00000471646.6
    Conserved Domains (2) summary
    smart00008
    Location:36107
    HormR; Domain present in hormone receptors
    cd15446
    Location:113376
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    30649406..30700103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011752.2XP_016867241.1  corticotropin-releasing factor receptor 2 isoform X2

    UniProtKB/Swiss-Prot
    Q13324
    Conserved Domains (2) summary
    smart00008
    Location:2293
    HormR; Domain present in hormone receptors
    pfam00002
    Location:99341
    7tm_2; 7 transmembrane receptor (Secretin family)
  2. XM_024446665.1XP_024302433.1  corticotropin-releasing factor receptor 2 isoform X1

    Conserved Domains (2) summary
    smart00008
    Location:36107
    HormR; Domain present in hormone receptors
    cd15446
    Location:113376
    7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors
Support Center