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Crhr2 corticotropin releasing hormone receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 12922, updated on 5-Jan-2023

Summary

Official Symbol
Crhr2provided by MGI
Official Full Name
corticotropin releasing hormone receptor 2provided by MGI
Primary source
MGI:MGI:894312
See related
Ensembl:ENSMUSG00000003476 AllianceGenome:MGI:894312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crfr2; CRF-R2; CRFR2beta; CRFR2alpha
Summary
Enables corticotrophin-releasing factor receptor activity and hormone activity. Acts upstream of or within G protein-coupled receptor signaling pathway; negative regulation of angiogenesis; and regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in Golgi apparatus; cell surface; and endoplasmic reticulum. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 14.2), mammary gland adult (RPKM 3.1) and 2 other tissues See more
Orthologs
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Genomic context

See Crhr2 in Genome Data Viewer
Location:
6 B3; 6 27.33 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (55067033..55110001, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (55090048..55133016, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38539 Neighboring gene glycyl-tRNA synthetase Neighboring gene predicted gene, 34358 Neighboring gene indolethylamine N-methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables corticotrophin-releasing factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables corticotrophin-releasing factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables corticotropin-releasing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables corticotropin-releasing hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in catecholamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in gastric motility ISO
Inferred from Sequence Orthology
more info
 
involved_in long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of defecation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of follicle-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of luteinizing hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of serotonin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cell body fiber ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in varicosity ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
corticotropin-releasing factor receptor 2
Names
CRF 2 receptor
CRF-R-2
CRF-RB
CRFR-2
CRH-R-2
CRH-R2
corticotropin releasing factor receptor type 2 beta
corticotropin-releasing factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288618.1NP_001275547.1  corticotropin-releasing factor receptor 2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK085854, AK142261, CJ065172
    Consensus CDS
    CCDS85053.1
    UniProtKB/TrEMBL
    A0A1D5RLK7, Q3UQP0
    Related
    ENSMUSP00000148408.2, ENSMUST00000212633.2
    Conserved Domains (2) summary
    smart00008
    Location:56127
    HormR; Domain present in hormone receptors
    pfam00002
    Location:133375
    7tm_2; 7 transmembrane receptor (Secretin family)
  2. NM_001288619.1NP_001275548.1  corticotropin-releasing factor receptor 2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001275548.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK142261, AY445512
    Consensus CDS
    CCDS85052.1
    UniProtKB/Swiss-Prot
    Q60748, Q60808
    UniProtKB/TrEMBL
    Q3UQP0
    Related
    ENSMUSP00000148297.2, ENSMUST00000213026.2
    Conserved Domains (2) summary
    smart00008
    Location:36107
    HormR; Domain present in hormone receptors
    pfam00002
    Location:113355
    7tm_2; 7 transmembrane receptor (Secretin family)
  3. NM_001288620.1NP_001275549.1  corticotropin-releasing factor receptor 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK142261, AY753668
    UniProtKB/TrEMBL
    Q3UQP0, Q5ERJ2
    Conserved Domains (1) summary
    pfam00002
    Location:37250
    7tm_2; 7 transmembrane receptor (Secretin family)
  4. NM_009953.4NP_034083.2  corticotropin-releasing factor receptor 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_034083.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but lacks an alternate internal aa compared to isoform 1.
    Source sequence(s)
    AK085854, AK142261
    Consensus CDS
    CCDS20162.1
    UniProtKB/TrEMBL
    Q3UQP0
    Related
    ENSMUSP00000003568.9, ENSMUST00000003568.15
    Conserved Domains (2) summary
    smart00008
    Location:56127
    HormR; Domain present in hormone receptors
    pfam00002
    Location:132374
    7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    55067033..55110001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505482.4XP_006505545.1  corticotropin-releasing factor receptor 2 isoform X1

    UniProtKB/TrEMBL
    E9QNK5
    Related
    ENSMUSP00000110015.3, ENSMUST00000114374.9
    Conserved Domains (3) summary
    smart00008
    Location:36107
    HormR; Domain present in hormone receptors
    cd14964
    Location:114139
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:112375
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily