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Ptprv protein tyrosine phosphatase receptor type V [ Mus musculus (house mouse) ]

Gene ID: 13924, updated on 12-May-2024

Summary

Official Symbol
Ptprvprovided by MGI
Official Full Name
protein tyrosine phosphatase receptor type Vprovided by MGI
Primary source
MGI:MGI:108027
See related
Ensembl:ENSMUSG00000097993 AllianceGenome:MGI:108027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Esp; OST; OST-PTP
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; limb; and skeleton. Orthologous to human PTPRVP (protein tyrosine phosphatase receptor type V, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Biased expression in ovary adult (RPKM 6.0), limb E14.5 (RPKM 4.0) and 11 other tissues See more
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Genomic context

See Ptprv in Genome Data Viewer
Location:
1 E4; 1 58.24 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135036236..135060313, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135108498..135132575, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1231 Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6 Neighboring gene STARR-seq mESC enhancer starr_02346 Neighboring gene STARR-seq mESC enhancer starr_02347 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:137029652-137029867 Neighboring gene STARR-positive B cell enhancer ABC_E9480 Neighboring gene protein tyrosine phosphatase, non-receptor type 7 Neighboring gene ADP-ribosylation factor-like 8A Neighboring gene G protein-coupled receptor 37-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (6)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of fibroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mitotic G1 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of fibroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein carboxylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within type B pancreatic cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase V
Names
ES cell phosphatase
R-PTP-V
embryonic stem cell protein-tyrosine phosphatase
tyrosine phosphatase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007955.3NP_031981.3  receptor-type tyrosine-protein phosphatase V precursor

    Status: VALIDATED

    Description
    Transcript Variant: This represents a protein-coding allele found in the NOD strain.
    Source sequence(s)
    AK156112
    UniProtKB/TrEMBL
    Q9ERK5
    Conserved Domains (6) summary
    smart00060
    Location:473551
    FN3; Fibronectin type 3 domain
    smart00194
    Location:11501408
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:11761408
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:656730
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:36109
    fn3; Fibronectin type III domain
    cl21483
    Location:15211692
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RNA

  1. NR_153383.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This represents a non-coding allele found in the reference strain.
    Source sequence(s)
    AC133097
    Related
    ENSMUST00000183317.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    135036236..135060313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)