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Nr2f6 nuclear receptor subfamily 2, group F, member 6 [ Mus musculus (house mouse) ]

Gene ID: 13864, updated on 13-May-2025
Official Symbol
Nr2f6provided by MGI
Official Full Name
nuclear receptor subfamily 2, group F, member 6provided by MGI
Primary source
MGI:MGI:1352453
See related
Ensembl:ENSMUSG00000002393 AllianceGenome:MGI:1352453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EAR2; Erbal2; COUP-TF3
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within detection of temperature stimulus involved in sensory perception of pain; entrainment of circadian clock by photoperiod; and neuron development. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Orthologous to human NR2F6 (nuclear receptor subfamily 2 group F member 6). [provided by Alliance of Genome Resources, May 2025]
Expression
Broad expression in duodenum adult (RPKM 104.5), colon adult (RPKM 86.8) and 26 other tissues See more
Orthologs
human all
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See Nr2f6 in Genome Data Viewer
Location:
8 B3.3; 8 34.43 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71826762..71834593, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71374118..71381967, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene unconventional SNARE in the ER 1 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E6650 Neighboring gene occludin/ELL domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_21812 Neighboring gene USH1 protein network component harmonin binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E881 Neighboring gene BRISC and BRCA1 A complex member 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. The orphan nuclear receptor Ear-2 (Nr2f6) is a novel negative regulator of T cell development. Ichim CV, et al. Exp Hematol, 2014 Jan. PMID 24096122
  2. The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity. Yang C, et al. PLoS Pathog, 2024 Jun. PMID 38829910, Free PMC Article
  3. Melanoma-intrinsic NR2F6 activity regulates antitumor immunity. Kim H, et al. Sci Adv, 2023 Jul 7. PMID 37406115, Free PMC Article
  4. A role for the nuclear receptor NR2F6 in peritoneal B cell homeostasis. Olson WJ, et al. Front Immunol, 2022. PMID 36052079, Free PMC Article
  5. Loss of the orphan nuclear receptor NR2F6 enhances CD8(+) T-cell memory via IFN-γ. Jakic B, et al. Cell Death Dis, 2021 Feb 15. PMID 33589606, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6.
    Title: Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6.
  2. Trefoil factor 3 can stimulate Th17 cell response in the development of type 2 diabetes mellitus.
    Title: Trefoil factor 3 can stimulate Th17 cell response in the development of type 2 diabetes mellitus.
  3. NR2F6 is essential for brown adipocyte differentiation and systemic metabolic homeostasis.
    Title: NR2F6 is essential for brown adipocyte differentiation and systemic metabolic homeostasis.
  4. Melanoma-intrinsic NR2F6 activity regulates antitumor immunity.
    Title: Melanoma-intrinsic NR2F6 activity regulates antitumor immunity.
  5. A role for the nuclear receptor NR2F6 in peritoneal B cell homeostasis.
    Title: A role for the nuclear receptor NR2F6 in peritoneal B cell homeostasis.
  6. Loss of the orphan nuclear receptor NR2F6 enhances CD8(+) T-cell memory via IFN-gamma.
    Title: Loss of the orphan nuclear receptor NR2F6 enhances CD8(+) T-cell memory via IFN-γ.
  7. Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy.
    Title: Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy.
  8. Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21.
    Title: Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21.
  9. NR2F6 is an intracellular immune checkpoint that suppresses adaptive anti-cancer immune responses
    Title: Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.
  10. NR2F6 is a central checkpoint for cancer immune surveillance.
    Title: The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
nuclear receptor subfamily 2 group F member 6
Names
COUP transcription factor 3
EAR-2
V-erbA-related protein 2
avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417423.1 → NP_001404352.1  nuclear receptor subfamily 2 group F member 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127416

  2. NM_010150.3 → NP_034280.2  nuclear receptor subfamily 2 group F member 6 isoform 1

    See identical proteins and their annotated locations for NP_034280.2

    Status: VALIDATED

    Source sequence(s)
    AC127416
    Consensus CDS
    CCDS22392.1
    UniProtKB/Swiss-Prot
    P43136, Q61504, Q922G8
    UniProtKB/TrEMBL
    Q3UIT0
    Related
    ENSMUSP00000002466.9, ENSMUST00000002466.9
    Conserved Domains (2) summary
    cd06948
    Location:157 → 387
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
    cd06958
    Location:57 → 129
    NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

RNA

  1. NR_184449.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127416

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71826762..71834593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242264.2 → XP_011240566.1  nuclear receptor subfamily 2 group F member 6 isoform X2

    Conserved Domains (2) summary
    cd06948
    Location:77 → 307
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
    cl02596
    Location:14 → 49
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

  2. XM_011242265.3 → XP_011240567.1  nuclear receptor subfamily 2 group F member 6 isoform X4

    Conserved Domains (1) summary
    cd06948
    Location:34 → 264
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43136.2 GenPept UniProtKB/Swiss-Prot:P43136

Gene LinkOut

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