Nr2f6 nuclear receptor subfamily 2, group F, member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nr2f6provided by MGI
Official Full Name: nuclear receptor subfamily 2, group F, member 6provided by MGI
Primary source: MGI:MGI:1352453
See related: Ensembl:ENSMUSG00000002393 AllianceGenome:MGI:1352453
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EAR2; Erbal2; COUP-TF3
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within detection of temperature stimulus involved in sensory perception of pain; entrainment of circadian clock by photoperiod; and neuron development. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human NR2F6 (nuclear receptor subfamily 2 group F member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in duodenum adult (RPKM 104.5), colon adult (RPKM 86.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.43 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (71826762..71834922, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (71374118..71381967, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A role for the nuclear receptor NR2F6 in peritoneal B cell homeostasis.
Title: A role for the nuclear receptor NR2F6 in peritoneal B cell homeostasis.
Loss of the orphan nuclear receptor NR2F6 enhances CD8(+) T-cell memory via IFN-gamma.
Title: Loss of the orphan nuclear receptor NR2F6 enhances CD8<sup>+</sup> T-cell memory via IFN-γ.
Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy.
Title: Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy.
Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21.
Title: Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21.
NR2F6 is an intracellular immune checkpoint that suppresses adaptive anti-cancer immune responses
Title: Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.
NR2F6 is a central checkpoint for cancer immune surveillance.
Title: The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.
Snail inhibits adipogenesis through a down-regulation of Nr2f6, which in turn facilitates the expression of IL-17, an anti-adipogenic cytokine.
Title: A proteomic analysis reveals that Snail regulates the expression of the nuclear orphan receptor Nuclear Receptor Subfamily 2 Group F Member 6 (Nr2f6) and interleukin 17 (IL-17) to inhibit adipocyte differentiation.
The orphan nuclear receptor Ear-2 (Nr2f6) is a novel negative regulator of T cell development.
Title: The orphan nuclear receptor Ear-2 (Nr2f6) is a novel negative regulator of T cell development.
EAR2/NR2F6 and related NRs such as the COUPTFs, TLX and PNR can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains. The interaction with BCL11A facilitates COUP-TFII-mediated repression of the RARb2 gene.
Title: A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.
Interaction of NSD1 with the NR2E/F subfamily including COUP-TFI, COUP-TFII, EAR2 and TLX requires a F/YSXXLXXL/Y motif. NSD1 interaction with liganded NRs is mediated by an overlapping LXXLL motif.
Title: A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nr2f6 (e-PCR), detects polymorphism
- UniSTS:507939

AI326022 (e-PCR)
- UniSTS:179759

AV090102 (e-PCR)
- UniSTS:179763

X76654 (e-PCR)
- UniSTS:163440

X76654 (e-PCR)
- UniSTS:125851

Nr2f6 (e-PCR), detects polymorphism
- UniSTS:525503

Nr2f6 (e-PCR), detects polymorphism
- UniSTS:536538

Homology

Homologs of the Nr2f6 gene: The Nr2f6 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 283 organisms have orthologs with human gene Nr2f6
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor subfamily 2 group F member 6

Names: COUP transcription factor 3; EAR-2; V-erbA-related protein 2; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010150.2 → NP_034280.2 nuclear receptor subfamily 2 group F member 6

See identical proteins and their annotated locations for NP_034280.2

Status: VALIDATED

Source sequence(s)

AK131941, AK171552, CJ182623

Consensus CDS

CCDS22392.1

UniProtKB/Swiss-Prot

P43136, Q922G8

UniProtKB/TrEMBL

A0A6P5Q0Y3, A0A8C6MVY4

Related

ENSMUSP00000002466.9, ENSMUST00000002466.9

Conserved Domains (2) summary

cd06948
Location:157 → 387

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

cd06958
Location:57 → 129

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

71826762..71834922 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509553.4 → XP_006509616.1 nuclear receptor subfamily 2 group F member 6 isoform X1

Conserved Domains (2) summary

cd06958
Location:57 → 129

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

cl11397
Location:157 → 310

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
XM_036153751.1 → XP_036009644.1 nuclear receptor subfamily 2 group F member 6 isoform X3

Conserved Domains (1) summary

cd06948
Location:36 → 266

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
XM_011242264.2 → XP_011240566.1 nuclear receptor subfamily 2 group F member 6 isoform X2

Conserved Domains (2) summary

cd06948
Location:77 → 307

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

cl02596
Location:14 → 49

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
XM_011242265.3 → XP_011240567.1 nuclear receptor subfamily 2 group F member 6 isoform X4

Conserved Domains (1) summary

cd06948
Location:34 → 264

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family