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Nr2f6 nuclear receptor subfamily 2, group F, member 6 [ Mus musculus (house mouse) ]

Gene ID: 13864, updated on 8-Dec-2022

Summary

Official Symbol
Nr2f6provided by MGI
Official Full Name
nuclear receptor subfamily 2, group F, member 6provided by MGI
Primary source
MGI:MGI:1352453
See related
Ensembl:ENSMUSG00000002393 AllianceGenome:MGI:1352453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EAR2; Erbal2; COUP-TF3
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within detection of temperature stimulus involved in sensory perception of pain; entrainment of circadian clock by photoperiod; and neuron development. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human NR2F6 (nuclear receptor subfamily 2 group F member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 104.5), colon adult (RPKM 86.8) and 26 other tissues See more
Orthologs
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Genomic context

See Nr2f6 in Genome Data Viewer
Location:
8 B3.3; 8 34.43 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71826762..71834922, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71374118..71381967, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene unconventional SNARE in the ER 1 homolog (S. cerevisiae) Neighboring gene occludin/ELL domain containing 1 Neighboring gene USH1 protein network component harmonin binding protein 1 Neighboring gene BRISC and BRCA1 A complex member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear receptor subfamily 2 group F member 6
Names
COUP transcription factor 3
EAR-2
V-erbA-related protein 2
avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010150.2NP_034280.2  nuclear receptor subfamily 2 group F member 6

    See identical proteins and their annotated locations for NP_034280.2

    Status: VALIDATED

    Source sequence(s)
    AK131941, AK171552, CJ182623
    Consensus CDS
    CCDS22392.1
    UniProtKB/Swiss-Prot
    P43136, Q922G8
    UniProtKB/TrEMBL
    A0A6P5Q0Y3, A0A8C6MVY4
    Related
    ENSMUSP00000002466.9, ENSMUST00000002466.9
    Conserved Domains (2) summary
    cd06948
    Location:157387
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
    cd06958
    Location:57129
    NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71826762..71834922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509553.4XP_006509616.1  nuclear receptor subfamily 2 group F member 6 isoform X1

    Conserved Domains (2) summary
    cd06958
    Location:57129
    NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers
    cl11397
    Location:157310
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. XM_036153751.1XP_036009644.1  nuclear receptor subfamily 2 group F member 6 isoform X3

    Conserved Domains (1) summary
    cd06948
    Location:36266
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
  3. XM_011242264.2XP_011240566.1  nuclear receptor subfamily 2 group F member 6 isoform X2

    Conserved Domains (2) summary
    cd06948
    Location:77307
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
    cl02596
    Location:1449
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  4. XM_011242265.3XP_011240567.1  nuclear receptor subfamily 2 group F member 6 isoform X4

    Conserved Domains (1) summary
    cd06948
    Location:34264
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family