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NR2F6 nuclear receptor subfamily 2 group F member 6 [ Homo sapiens (human) ]

Gene ID: 2063, updated on 9-Feb-2020

Summary

Official Symbol
NR2F6provided by HGNC
Official Full Name
nuclear receptor subfamily 2 group F member 6provided by HGNC
Primary source
HGNC:HGNC:7977
See related
Ensembl:ENSG00000160113 MIM:132880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EAR2; EAR-2; ERBAL2
Expression
Broad expression in colon (RPKM 27.8), stomach (RPKM 20.8) and 23 other tissues See more
Orthologs

Genomic context

See NR2F6 in Genome Data Viewer
Location:
19p13.11
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (17231885..17245342, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17342692..17356744, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene unconventional SNARE in the ER 1 Neighboring gene occludin/ELL domain containing 1 Neighboring gene USH1 protein network component harmonin binding protein 1 Neighboring gene BRISC and BRCA1 A complex member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detection of temperature stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
entrainment of circadian clock by photoperiod IEA
Inferred from Electronic Annotation
more info
 
intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
neuron development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear receptor subfamily 2 group F member 6
Names
ERBA-related gene-2
V-erbA-related protein 2
nuclear receptor V-erbA-related
v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005234.3NP_005225.2  nuclear receptor subfamily 2 group F member 6

    See identical proteins and their annotated locations for NP_005225.2

    Status: VALIDATED

    Source sequence(s)
    BC002669
    Consensus CDS
    CCDS12352.1
    UniProtKB/Swiss-Prot
    P10588
    UniProtKB/TrEMBL
    F1D8R3
    Related
    ENSP00000291442.2, ENST00000291442.3
    Conserved Domains (2) summary
    cd06948
    Location:165400
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
    cd06958
    Location:56128
    NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    17231885..17245342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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