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Epn1 epsin 1 [ Mus musculus (house mouse) ]

Gene ID: 13854, updated on 5-Mar-2024

Summary

Official Symbol
Epn1provided by MGI
Official Full Name
epsin 1provided by MGI
Primary source
MGI:MGI:1333763
See related
Ensembl:ENSMUSG00000035203 AllianceGenome:MGI:1333763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ibp1
Summary
Predicted to enable clathrin adaptor activity; phospholipid binding activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including Notch signaling pathway; female pregnancy; and in utero embryonic development. Predicted to be located in cytosol; nucleus; and presynapse. Predicted to be extrinsic component of cytoplasmic side of plasma membrane; extrinsic component of postsynaptic membrane; and extrinsic component of presynaptic membrane. Predicted to be part of clathrin vesicle coat. Predicted to be active in endosome and plasma membrane. Orthologous to human EPN1 (epsin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 208.8), colon adult (RPKM 120.0) and 28 other tissues See more
Orthologs
NEW
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Genomic context

See Epn1 in Genome Data Viewer
Location:
7 A1; 7 2.94 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (5083207..5101178)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (5080137..5098179)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15510 Neighboring gene coiled-coil domain containing 106 Neighboring gene STARR-positive B cell enhancer ABC_E3697 Neighboring gene STARR-positive B cell enhancer ABC_E9020 Neighboring gene STARR-positive B cell enhancer ABC_E4891 Neighboring gene U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 Neighboring gene STARR-positive B cell enhancer ABC_E4892 Neighboring gene ret finger protein-like 4 Neighboring gene RAS-like, family 2, locus 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC106041

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular sequestering activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic organ development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within female pregnancy IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in membrane fission ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
part_of clathrin vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
epsin-1
Names
EPS-15-interacting protein 1
intersectin-EH-binding protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252454.2NP_001239383.1  epsin-1 isoform 1

    See identical proteins and their annotated locations for NP_001239383.1

    Status: VALIDATED

    Source sequence(s)
    AC162893
    Consensus CDS
    CCDS20758.1
    UniProtKB/Swiss-Prot
    O70446, Q6NX78, Q80VP1
    Related
    ENSMUSP00000043340.7, ENSMUST00000045277.7
    Conserved Domains (2) summary
    PRK07764
    Location:270437
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd16990
    Location:19142
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  2. NM_001372500.1NP_001359429.1  epsin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162893
    Consensus CDS
    CCDS90155.1
    Conserved Domains (3) summary
    PHA03247
    Location:256524
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:267393
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd16990
    Location:19142
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  3. NM_001412337.1NP_001399266.1  epsin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC162893
    UniProtKB/Swiss-Prot
    O70446, Q6NX78, Q80VP1
  4. NM_001412338.1NP_001399267.1  epsin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC162893
    UniProtKB/Swiss-Prot
    O70446, Q6NX78, Q80VP1
  5. NM_001412339.1NP_001399268.1  epsin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC162893
    UniProtKB/Swiss-Prot
    O70446, Q6NX78, Q80VP1
  6. NM_001412340.1NP_001399269.1  epsin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC162893
    UniProtKB/Swiss-Prot
    O70446, Q6NX78, Q80VP1
  7. NM_001412341.1NP_001399270.1  epsin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC162893
    UniProtKB/Swiss-Prot
    O70446, Q6NX78, Q80VP1
  8. NM_001412342.1NP_001399271.1  epsin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC162893
    UniProtKB/Swiss-Prot
    O70446, Q6NX78, Q80VP1
  9. NM_001412343.1NP_001399272.1  epsin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC162893
    UniProtKB/Swiss-Prot
    O70446, Q6NX78, Q80VP1
  10. NM_001412344.1NP_001399273.1  epsin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC162893
    UniProtKB/Swiss-Prot
    O70446, Q6NX78, Q80VP1
  11. NM_001412345.1NP_001399274.1  epsin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162893
  12. NM_001412346.1NP_001399275.1  epsin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162893
  13. NM_001412347.1NP_001399276.1  epsin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162893
  14. NM_001412348.1NP_001399277.1  epsin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162893
  15. NM_001412349.1NP_001399278.1  epsin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162893
  16. NM_001412350.1NP_001399279.1  epsin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162893
    Related
    ENSMUSP00000146638.2, ENSMUST00000208634.2
  17. NM_001412351.1NP_001399280.1  epsin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162893
  18. NM_001412352.1NP_001399281.1  epsin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162893
  19. NM_001412353.1NP_001399282.1  epsin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162893
  20. NM_001412354.1NP_001399283.1  epsin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC162893
  21. NM_001412355.1NP_001399284.1  epsin-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC162893
  22. NM_001412356.1NP_001399285.1  epsin-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC162893
  23. NM_001412357.1NP_001399286.1  epsin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162893
  24. NM_001412358.1NP_001399287.1  epsin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162893
  25. NM_001412359.1NP_001399288.1  epsin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162893
  26. NM_001412360.1NP_001399289.1  epsin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162893
  27. NM_001412361.1NP_001399290.1  epsin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162893
  28. NM_001412362.1NP_001399291.1  epsin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162893
  29. NM_001412363.1NP_001399292.1  epsin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162893
  30. NM_001412364.1NP_001399293.1  epsin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162893
  31. NM_001412365.1NP_001399294.1  epsin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162893
  32. NM_001412366.1NP_001399295.1  epsin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC162893
  33. NM_001412367.1NP_001399296.1  epsin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  34. NM_001412368.1NP_001399297.1  epsin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  35. NM_001412369.1NP_001399298.1  epsin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  36. NM_001412370.1NP_001399299.1  epsin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  37. NM_001412371.1NP_001399300.1  epsin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  38. NM_001412372.1NP_001399301.1  epsin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  39. NM_001412373.1NP_001399302.1  epsin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  40. NM_001412374.1NP_001399303.1  epsin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  41. NM_001412375.1NP_001399304.1  epsin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  42. NM_001412376.1NP_001399305.1  epsin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  43. NM_001412377.1NP_001399306.1  epsin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC162893
  44. NM_001412378.1NP_001399307.1  epsin-1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC162893
  45. NM_001412379.1NP_001399308.1  epsin-1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC162893
  46. NM_001412380.1NP_001399309.1  epsin-1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC162893
  47. NM_001412381.1NP_001399310.1  epsin-1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC162893
  48. NM_001412382.1NP_001399311.1  epsin-1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC162893
  49. NM_001412383.1NP_001399312.1  epsin-1 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC162893
  50. NM_001412384.1NP_001399313.1  epsin-1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC162893
  51. NM_001412385.1NP_001399314.1  epsin-1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC162893
  52. NM_001412386.1NP_001399315.1  epsin-1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC162893
  53. NM_001412388.1NP_001399317.1  epsin-1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC162893
  54. NM_001412389.1NP_001399318.1  epsin-1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC162893
  55. NM_001412390.1NP_001399319.1  epsin-1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC162893
  56. NM_001412391.1NP_001399320.1  epsin-1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC162893
  57. NM_001412392.1NP_001399321.1  epsin-1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC162893
  58. NM_001412393.1NP_001399322.1  epsin-1 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC162893
  59. NM_001412394.1NP_001399323.1  epsin-1 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC162893
  60. NM_001412395.1NP_001399324.1  epsin-1 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC162893
  61. NM_001412397.1NP_001399326.1  epsin-1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC162893
  62. NM_001412398.1NP_001399327.1  epsin-1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC162893
  63. NM_001412399.1NP_001399328.1  epsin-1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC162893
  64. NM_001412400.1NP_001399329.1  epsin-1 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC162893
  65. NM_001412401.1NP_001399330.1  epsin-1 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC162893
  66. NM_001412402.1NP_001399331.1  epsin-1 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC162893
  67. NM_001412403.1NP_001399332.1  epsin-1 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC162893
  68. NM_010147.5NP_034277.1  epsin-1 isoform 1

    See identical proteins and their annotated locations for NP_034277.1

    Status: VALIDATED

    Source sequence(s)
    AC162893
    Consensus CDS
    CCDS20758.1
    UniProtKB/Swiss-Prot
    O70446, Q6NX78, Q80VP1
    Related
    ENSMUSP00000096445.4, ENSMUST00000098845.10
    Conserved Domains (2) summary
    PRK07764
    Location:270437
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd16990
    Location:19142
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    5083207..5101178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539531.4XP_006539594.2  epsin-1 isoform X1

    See identical proteins and their annotated locations for XP_006539594.2

    UniProtKB/Swiss-Prot
    Q80VP1
    Conserved Domains (3) summary
    PHA03247
    Location:256524
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:267393
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd16990
    Location:19142
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  2. XM_030242119.1XP_030097979.1  epsin-1 isoform X11

    Conserved Domains (2) summary
    PHA03247
    Location:63333
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:74200
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
  3. XM_036152660.1XP_036008553.1  epsin-1 isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:256524
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:267393
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd16990
    Location:19142
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  4. XM_036152661.1XP_036008554.1  epsin-1 isoform X6

    UniProtKB/Swiss-Prot
    O70446, Q6NX78, Q80VP1
    Conserved Domains (2) summary
    PRK07764
    Location:270437
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd16990
    Location:19142
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family