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CRABP2 cellular retinoic acid binding protein 2 [ Homo sapiens (human) ]

Gene ID: 1382, updated on 3-Jan-2019

Summary

Official Symbol
CRABP2provided by HGNC
Official Full Name
cellular retinoic acid binding protein 2provided by HGNC
Primary source
HGNC:HGNC:2339
See related
Ensembl:ENSG00000143320 MIM:180231
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBP6; CRABP-II
Summary
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]
Expression
Biased expression in esophagus (RPKM 46.7), skin (RPKM 7.1) and 2 other tissues See more
Orthologs

Genomic context

See CRABP2 in Genome Data Viewer
Location:
1q23.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (156699606..156705816, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156669398..156675608, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371453 Neighboring gene VISTA enhancer hs1891 Neighboring gene nestin Neighboring gene interferon stimulated exonuclease gene 20 like 2 Neighboring gene ribosomal RNA adenine dimethylase domain containing 1 Neighboring gene mitochondrial ribosomal protein L24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Retinoic Acid, organism-specific biosystem (from REACTOME)
    Signaling by Retinoic Acid, organism-specific biosystemVitamin A (retinol) can be metabolised into active retinoid metabolites that function either as a chromophore in vision or in regulating gene expression transcriptionally and post-transcriptionally. ...
  • Vitamin A and Carotenoid Metabolism, organism-specific biosystem (from WikiPathways)
    Vitamin A and Carotenoid Metabolism, organism-specific biosystemThis pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinal binding IEA
Inferred from Electronic Annotation
more info
 
retinoic acid binding IEA
Inferred from Electronic Annotation
more info
 
retinoid binding TAS
Traceable Author Statement
more info
PubMed 
retinol binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of collateral sprouting IEA
Inferred from Electronic Annotation
more info
 
regulation of retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
retinoic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cellular retinoic acid-binding protein 2
Names
cellular retinoic acid-binding protein II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199723.1NP_001186652.1  cellular retinoic acid-binding protein 2

    See identical proteins and their annotated locations for NP_001186652.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AU126559, BC001109
    Consensus CDS
    CCDS1152.1
    UniProtKB/Swiss-Prot
    P29373
    Related
    ENSP00000482841.1, ENST00000621784.4
    Conserved Domains (1) summary
    pfam00061
    Location:5138
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  2. NM_001878.4NP_001869.1  cellular retinoic acid-binding protein 2

    See identical proteins and their annotated locations for NP_001869.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AK312007, BC001109
    Consensus CDS
    CCDS1152.1
    UniProtKB/Swiss-Prot
    P29373
    Related
    ENSP00000357205.3, ENST00000368222.7
    Conserved Domains (1) summary
    pfam00061
    Location:5138
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    156699606..156705816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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