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CRABP2 cellular retinoic acid binding protein 2 [ Homo sapiens (human) ]

Gene ID: 1382, updated on 22-Jan-2024

Summary

Official Symbol
CRABP2provided by HGNC
Official Full Name
cellular retinoic acid binding protein 2provided by HGNC
Primary source
HGNC:HGNC:2339
See related
Ensembl:ENSG00000143320 MIM:180231; AllianceGenome:HGNC:2339
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBP6; CRABP-II
Summary
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]
Expression
Biased expression in esophagus (RPKM 46.7), skin (RPKM 7.1) and 2 other tissues See more
Orthologs
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Genomic context

See CRABP2 in Genome Data Viewer
Location:
1q23.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156699606..156705784, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155836009..155842185, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156669398..156675576, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156616142-156616665 Neighboring gene BCAN antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156624901-156625401 Neighboring gene brevican Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156626597-156627098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156627099-156627599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156628979-156629479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1433 Neighboring gene VISTA enhancer hs1891 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156636725-156637298 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156642834-156643494 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156643495-156644156 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156645479-156646139 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156646801-156647461 Neighboring gene nestin Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156661895-156662812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156674429-156674930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156676520-156677196 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156677875-156678551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156682885-156683400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1434 Neighboring gene interferon stimulated exonuclease gene 20 like 2 Neighboring gene methyltransferase like 25B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:156711011-156711988 Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene heparin binding growth factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables retinal binding IEA
Inferred from Electronic Annotation
more info
 
enables retinoic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables retinoid binding TAS
Traceable Author Statement
more info
PubMed 
enables retinol binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermis development TAS
Traceable Author Statement
more info
PubMed 
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of collateral sprouting IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in retinoic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cellular retinoic acid-binding protein 2
Names
cellular retinoic acid-binding protein II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199723.2NP_001186652.1  cellular retinoic acid-binding protein 2

    See identical proteins and their annotated locations for NP_001186652.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AU126559, BC001109
    Consensus CDS
    CCDS1152.1
    UniProtKB/Swiss-Prot
    B2R4Z8, D3DVC5, F1T098, P29373, Q6ICN6
    Related
    ENSP00000482841.1, ENST00000621784.4
    Conserved Domains (1) summary
    cd19461
    Location:3138
    CRABP2; Cellular retinoic acid-binding protein 2
  2. NM_001878.4NP_001869.1  cellular retinoic acid-binding protein 2

    See identical proteins and their annotated locations for NP_001869.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AK312007, BC001109
    Consensus CDS
    CCDS1152.1
    UniProtKB/Swiss-Prot
    B2R4Z8, D3DVC5, F1T098, P29373, Q6ICN6
    Related
    ENSP00000357205.3, ENST00000368222.8
    Conserved Domains (1) summary
    cd19461
    Location:3138
    CRABP2; Cellular retinoic acid-binding protein 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156699606..156705784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155836009..155842185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)