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Crabp2 cellular retinoic acid binding protein II [ Mus musculus (house mouse) ]

Gene ID: 12904, updated on 8-Feb-2024

Summary

Official Symbol
Crabp2provided by MGI
Official Full Name
cellular retinoic acid binding protein IIprovided by MGI
Primary source
MGI:MGI:88491
See related
Ensembl:ENSMUSG00000004885 AllianceGenome:MGI:88491
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crabp-2; CrabpII
Summary
Enables retinoic acid binding activity. Acts upstream of or within embryonic forelimb morphogenesis; positive regulation of collateral sprouting; and retinoic acid metabolic process. Located in endoplasmic reticulum and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart and pericardium; and sensory organ. Orthologous to human CRABP2 (cellular retinoic acid binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 125.3), limb E14.5 (RPKM 55.3) and 3 other tissues See more
Orthologs
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Genomic context

See Crabp2 in Genome Data Viewer
Location:
3 F1; 3 38.78 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87856000..87860679)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87948693..87953372)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10190 Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene methyltransferase like 25B Neighboring gene STARR-positive B cell enhancer ABC_E9556 Neighboring gene interferon stimulated exonuclease gene 20-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E9216 Neighboring gene predicted gene, 32518 Neighboring gene predicted gene 3745

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables retinal binding IEA
Inferred from Electronic Annotation
more info
 
enables retinoic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables retinoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables retinoic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables retinol binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cellular retinoic acid-binding protein 2
Names
CRABP-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007759.2NP_031785.1  cellular retinoic acid-binding protein 2

    See identical proteins and their annotated locations for NP_031785.1

    Status: PROVISIONAL

    Source sequence(s)
    AC158233
    Consensus CDS
    CCDS17460.1
    UniProtKB/Swiss-Prot
    P22935
    Related
    ENSMUSP00000005019.6, ENSMUST00000005019.6
    Conserved Domains (1) summary
    cl10502
    Location:3138
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87856000..87860679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)