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CRABP1 cellular retinoic acid binding protein 1 [ Homo sapiens (human) ]

Gene ID: 1381, updated on 19-Aug-2018

Summary

Official Symbol
CRABP1provided by HGNC
Official Full Name
cellular retinoic acid binding protein 1provided by HGNC
Primary source
HGNC:HGNC:2338
See related
Ensembl:ENSG00000166426 MIM:180230; Vega:OTTHUMG00000143862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBP5; CRABP; CRABPI; CRABP-I
Summary
This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]
Expression
Biased expression in thyroid (RPKM 65.7), spleen (RPKM 23.2) and 3 other tissues See more
Orthologs

Genomic context

See CRABP1 in Genome Data Viewer
Location:
15q25.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (78340324..78348230)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (78632666..78640572)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370910 Neighboring gene DnaJ heat shock protein family (Hsp40) member A4 Neighboring gene WD repeat domain 61 Neighboring gene RWD domain containing 1 pseudogene 1 Neighboring gene uncharacterized LOC105370912

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • RA biosynthesis pathway, organism-specific biosystem (from REACTOME)
    RA biosynthesis pathway, organism-specific biosystemThe major activated retinoid, all-trans-retinoic acid (atRA) is produced by the dehydrogenation of all-trans-retinol (atROL) by members of the short chain dehydrogenase/reductase (SDR) and aldehyde d...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Retinoic Acid, organism-specific biosystem (from REACTOME)
    Signaling by Retinoic Acid, organism-specific biosystemVitamin A (retinol) can be metabolised into active retinoid metabolites that function either as a chromophore in vision or in regulating gene expression transcriptionally and post-transcriptionally. ...
  • Vitamin A and Carotenoid Metabolism, organism-specific biosystem (from WikiPathways)
    Vitamin A and Carotenoid Metabolism, organism-specific biosystemThis pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinal binding IEA
Inferred from Electronic Annotation
more info
 
retinoic acid binding IEA
Inferred from Electronic Annotation
more info
 
retinoid binding TAS
Traceable Author Statement
more info
PubMed 
retinol binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
retinoic acid catabolic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cellular retinoic acid-binding protein 1
Names
cellular retinoic acid-binding protein I

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004378.2NP_004369.1  cellular retinoic acid-binding protein 1

    See identical proteins and their annotated locations for NP_004369.1

    Status: REVIEWED

    Source sequence(s)
    AI863257, AU132726, BC022069
    Consensus CDS
    CCDS10301.1
    UniProtKB/Swiss-Prot
    P29762
    UniProtKB/TrEMBL
    F1T0F7
    Related
    ENSP00000299529.6, OTTHUMP00000185023, ENST00000299529.6, OTTHUMT00000290110
    Conserved Domains (1) summary
    pfam00061
    Location:5137
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    78340324..78348230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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