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CRABP1 cellular retinoic acid binding protein 1 [ Homo sapiens (human) ]

Gene ID: 1381, updated on 5-Aug-2022

Summary

Official Symbol
CRABP1provided by HGNC
Official Full Name
cellular retinoic acid binding protein 1provided by HGNC
Primary source
HGNC:HGNC:2338
See related
Ensembl:ENSG00000166426 MIM:180230; AllianceGenome:HGNC:2338
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBP5; CRABP; CRABPI; CRABP-I
Summary
This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]
Expression
Biased expression in thyroid (RPKM 65.7), spleen (RPKM 23.2) and 3 other tissues See more
Orthologs
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Genomic context

See CRABP1 in Genome Data Viewer
Location:
15q25.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (78340353..78348225)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (76202952..76210824)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (78632695..78640567)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370910 Neighboring gene DnaJ heat shock protein family (Hsp40) member A4 Neighboring gene Sharpr-MPRA regulatory region 12554 Neighboring gene SKI8 subunit of superkiller complex Neighboring gene RWD domain containing 1 pseudogene 1 Neighboring gene uncharacterized LOC105370912

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables retinal binding IEA
Inferred from Electronic Annotation
more info
 
enables retinoic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables retinoid binding TAS
Traceable Author Statement
more info
PubMed 
enables retinol binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retinoic acid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cellular retinoic acid-binding protein 1
Names
cellular retinoic acid-binding protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004378.3NP_004369.1  cellular retinoic acid-binding protein 1

    See identical proteins and their annotated locations for NP_004369.1

    Status: REVIEWED

    Source sequence(s)
    AI863257, AU132726, BC022069
    Consensus CDS
    CCDS10301.1
    UniProtKB/Swiss-Prot
    P29762, Q8WTV5
    UniProtKB/TrEMBL
    F1T0F7
    Related
    ENSP00000299529.6, ENST00000299529.7
    Conserved Domains (1) summary
    cd19460
    Location:2137
    CRABP1; cellular retinoic acid-binding protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    78340353..78348225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    76202952..76210824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)